Term
Define complete dominance and give an example. |
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Definition
The presence of the dominant allele masks the appearance of the recessive.
Thus, the phenotypes of the the heterozygote (Aa) and the dominant homozygote (AA) are indistinguishable.
Example: Mendel's peas
[image] |
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Term
Name five exceptions to Mendel's complete dominance. |
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Definition
- Incomplete Dominance
- Multiple Alleles
- Epistasis
- Pleiotropy
- Polygenic Inheritance
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Term
Define incomplete dominance and give an example. |
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Definition
Neither allele is completely dominant, and the F1 hybrids have a phenotype somewhere between those of the two parental varieties.
Example: Snapdragons
[image]
Phenotypic Ratio: 1 red:2 pink:1 white |
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Term
Doesn't incomplete dominance provide evidence for the blending hypothesis of inheritance since red and white make pink? |
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Definition
NO! The blending theory implies that the original traits (red and white) could never be retrieved from the pink hybrids, which is incorrect.
The segregation of the red-flower and the white-flower alleles in the gametes produced for flower color are heritable factors that maintain their identity in the hybrids (as seen in the incomplete dominance card).
2 pinks produce the 1 RED:2 pink:1 WHITE ratio. |
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Term
Give an example of when there may be multiple alleles on the same gene (and when I say multiple I mean more than two). |
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Definition
Blood type. ABO blood groups in humans are determined by three alleles on a single gene.
There are four blood types (A, B, O, AB), but there are still three alleles (A, B, O). |
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Term
What's special about the alleles IA and IB that allows humans to have a blood type of AB? |
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Definition
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Term
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Definition
Two alleles each affect the phenotype in separate, distinguishable ways. |
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Term
What blood type would you have if your genotype were homozygous recessive? |
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Definition
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Term
What distinguishes one blood type from another? |
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Definition
Sugars present on the membrane (or lackthereof in the case of type O). |
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Term
Define epistasis and give an example. |
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Definition
Gene at one locus alters expression of gene at another locus
Example: The dogs!
The E/e gene is epistatic to the B/b gene.
[image]
B=Black
b=brown
E=Expression of other gene at other locus
ee= Stops/halts expression
Notice all the ones with "ee" are albino. |
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Term
Define pleiotropy and give an example. |
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Definition
One gene/many phenotypes
Pleiotropic alleles are responsible for the multiple symptoms associated with certain hereditary diseases, such as cystic fibrosis and sickle-cell disease.
Example: Hemoglobin and sickle cell disease
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Term
Define polygenic inheritance and give an example. |
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Definition
This is the additive effect of two or more genes on a single phenotypic character, or one gene with multiple phenotypes. (Many genes/one phenotype)
Example: Skin tone
(Regarding skin tone, you can't say someone's skin tone is either _____ or _____; skin tone varies in gradations allong a continuum).
Also, A, B, and C genes in various genotypic combinations lead to different skin tones.
[image] |
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Term
Polygenic inheritance is the converse of _____________. |
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Definition
Pleiotropy.
(Since pleiotropy is one gene/multiple phenotypes and polygenic inheritance is many genes/one phenotype). |
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Term
What are epigenetic factors? Example? |
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Definition
Factors unrelated to inheritance.
The outcome of genotype lies within a phenotypic range that depends on the environment in which the genotype is expressed.
For example, hydrangea flowers of the same genetic variety range in color from blue-violet to pink, whith the sade and intensity of color depending on the acidity and aluminum content in the soil (so solely environmental stuff).
[image] |
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Term
What are pedigrees used for? |
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Definition
These are used for determining possible offspring based on family history.
[image]
Usually goes eldest child to youngest child from left to right.
[image]
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Term
Two methods of testing a fetus for genetic disorders? |
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Definition
- Amniocentisis
- Chorionic villus sampling (CVS)
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Term
If HbA is a normal allele and Hbs is a Sickle cell/mutant allele, how many possible phenotypes are there?
What are they?
The number of phenotypes indicates that the gene for hemoglobin is ______________. |
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Definition
3.
HbAHbA - You're have normal hemoglobin
HbAHbS - You're a carrier for sickle cell anemia
HbSHbS - You have sickle cell anemia/mutant hemoglobin protein
Pleiotropic. |
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