Term
Where are body fluids located? 3 main areas |
|
Definition
Interstitial fluid (80%) Plasma (20%) Lymph |
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Term
Where is the interstitial fluid? |
|
Definition
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|
Term
Where is the plasma fluid? |
|
Definition
Fluid portion o fblood- in blood vessels |
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|
Term
What does the lymph portion of fluid do? |
|
Definition
For purification of Blood |
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Term
What % is intracellular fluid and where is it? |
|
Definition
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|
Term
What % is extracellular fluid and where is it? |
|
Definition
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|
Term
What are the composition of fluids (3)? |
|
Definition
Solutes, Electrolytes, Non-electrolytes |
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|
Term
|
Definition
Substances dissolved in a solvent (water) |
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|
Term
|
Definition
Chemical substances that dissociate (ionize) in water |
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|
Term
What are examples of electrolytes? |
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Definition
Inorganic salts, acids and bases, and many proteins |
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Term
What is the contribution of electrolytes? |
|
Definition
Greatly effect osmolarity of solutions, fluid shifts |
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|
Term
What units are electrolytes expressed in? |
|
Definition
mEq/L milliequivalents per liter |
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Term
What type of bond do non-electrolytes have and what property is related to the bond? |
|
Definition
Covalent bonds that prevent them from dissociating |
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|
Term
What are examples of non-electrolytes? |
|
Definition
Organic molecules, glucose, lipids, urea, creatinine |
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|
Term
What contribution do non-elecrolytes make? |
|
Definition
less osmotic power than electrolytes |
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|
Term
What ions are high in extracellular fluids? |
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Definition
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|
Term
What ion(s) are high in intracellular fluids |
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Definition
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|
Term
What regulates the movement of fluids between compartments? |
|
Definition
Hydrostatic pressure and Osmotic pressure |
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Term
Describe hydrostatic pressure |
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Definition
Force exeerted by a fluid as it is pressed against the wall of a vessel. It will send fluid through capillaries. |
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Term
Describe Osmotic pressure |
|
Definition
Movement of water across semipermeable membrand along its concentration gradient. Blood filled with electrolytes--water follows it ...salt goes inside after a meal, increase blood pressure |
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Term
What type of pressure is indicative of force exeerted by a fluid as it is pressed against the wall of a vessel? |
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Definition
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|
Term
What pressure is indicative of movement of water across a semipermeable membrane along its concentration gradient? |
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Definition
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|
Term
What is located at the Arterial end of capillary exchange? |
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Definition
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Term
What is located at the venous end of capillary exchange? |
|
Definition
Filtrate can either go from tissue to CAPILLARY due to osmotic pressure- blood-osmotic pressure and Lymph-purification |
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Term
What are the 2 forms of water intake in the body? |
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Definition
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|
Term
Of the ingested water, what % is in liquid form and what % is in food? |
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Definition
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|
Term
What is ml intake level of water? |
|
Definition
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|
Term
How is metabolic water derived in body? |
|
Definition
Through dehydration synthesis in anabolic reactions |
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|
Term
What are the 4 ways water is output? |
|
Definition
kidneys, skin, lungs, gastrointestinal tract |
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|
Term
What % of water is output through kidneys and skin? |
|
Definition
Kidneys 60% urine 1500 ml/day and Skin 28%-500 ml 400 ml per day evaporation and 100 ml/day sweat |
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Term
What are the 2 mechanisms for fluid regulation? |
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Definition
Pressoreceptors and Osmoreceptors |
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Term
What do pressoreceptors do? |
|
Definition
Baroreceptors- detect high or low blood volumes |
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Term
What do Osmoreceptors do? |
|
Definition
Detect change in osmolarity |
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Term
With regard to osmoreceptors, an increase in solute per volume is indicative of what in terms of osmolarity? |
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Definition
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Term
In terms of osmolarity, a decrease in solvent per volume is indicative of what in terms of osmolarity? |
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Definition
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|
Term
What is Edema and what is it caused by? |
|
Definition
Excess water in interstitial spaces which imparis circulation- diabetics, pregnant women, ..hands and feet swell |
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|
Term
What is hypotonic hydration? |
|
Definition
Dilutional hypoatremia-water intoxication |
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|
Term
What causes hypotonic hydration? |
|
Definition
Renal failure or extraordinary water intake |
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|
Term
Waht is the effect of hypotonic hydration? |
|
Definition
ECS is diluted (water concentration is high) water to cells- edema-fluid build up in cells will burst |
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|
Term
What is the treatement for hypotonic hydration? |
|
Definition
Intravenous hypertonic saline |
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|
Term
What 4 ions are linked to electrolyte balance in the body? |
|
Definition
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|
Term
What is the importance of Na electrolyte balance? |
|
Definition
Linked to water, K, H, Cl, HcO3, blood pressure |
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|
Term
With Aldosterone increase in Na+ in blood, what happens |
|
Definition
100% Na+ reabsorption by kidney, cl- and water follow Na+ reabsorption...high salt diet increases water, increases blood volume increases blood pressure |
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|
Term
What effect does estrogen have on Na balance? |
|
Definition
Similar to aldesterone, reabsorption of Na and water following- explains premenstrual edema |
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|
Term
What effect does progesterone have on Na balance in the body? |
|
Definition
Blocks the effect of aldosterone, acts as a diuretic, levels decrease near period |
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|
Term
What effect do Glucocorticoids (cortisol) have on Na balance? |
|
Definition
Enhance water reabsorption-get swollen |
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|
Term
What is the effect of K balance in the body? |
|
Definition
Greatest effect on cell excitability and resting potential |
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|
Term
What effect does Aldesterone have on the K balance in the body? |
|
Definition
With reabsorption of Na, results in K secretion |
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|
Term
What effect does Acidosis have on K balance? |
|
Definition
Increases in blood acidity, ph is down |
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|
Term
What is the importance of Ca balance in the body? |
|
Definition
Bones, blood clotting, muscular contraction |
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|
Term
|
Definition
Increased excitability, tetany , muscle cramping- not enough Ca- bone fractures |
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|
Term
|
Definition
Decreased excitability, cardiac arrythmias- too much Ca |
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|
Term
What is the term for too littl Ca? |
|
Definition
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|
Term
What is the term for too much Ca? |
|
Definition
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|
Term
What is released when blood Ca is too low? |
|
Definition
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|
Term
|
Definition
Breaks down bones and releases calcium in blood |
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|
Term
What happens in Osteoclast activation? |
|
Definition
More absorption of Ca in blood and increase in reabsorption in kidneys |
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|
Term
What is the importance of calcium balance? |
|
Definition
bones, blood clotting, muscular contraction |
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|
Term
When the intestinal absorption of Ca increases, what happens? |
|
Definition
stimulates kidney to change vitamin D to the cofactor necessary for Ca absorption- INDIRECT |
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|
Term
Do renal tubes have increased or decreased absorption during Osteoclast activation with regard to calcium? |
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Definition
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|
Term
|
Definition
Regulator is released if Ca is too high triggering OsteoBLAST activation |
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|
Term
What specifically does OsteoBlast activation contribute to? |
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Definition
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|
Term
What does hypotensive mean with regard to Mg balance? |
|
Definition
Etracellular MG increase results in muscle weakness |
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|
Term
What does hypertensive mean with regard to Mg? |
|
Definition
Extracellular Mg decrease results in athersclerosis, stroke and increased lipid levels |
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|
Term
What conditions are prevalent when Mg is hypertensive? |
|
Definition
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|
Term
What conditions are prevalent when Mg is hypertensive? |
|
Definition
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|
Term
What is a word for Mg extracellular increase? |
|
Definition
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|
Term
What is a word for extracellular Mg decrease? |
|
Definition
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|
Term
|
Definition
When H concentration changes, buffers come in to help balance high or low concentrations |
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|
Term
|
Definition
Bicarbonate, Phosphate, and Protein |
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|
Term
Where is the phosphate buffer system? |
|
Definition
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|
Term
What specific components are part of the Phosphate buffer system? |
|
Definition
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|
Term
Which buffer involves exhaling CO2 to get rid of acid? |
|
Definition
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|
Term
What is amphoteric and which buffer system is associated specifically with this property? |
|
Definition
Acts as both an acid and base buffer- Protein buffer system |
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|
Term
Which buffer system is associated with HCl and NH2 to convert to NH3? |
|
Definition
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|
Term
When the end result is R-NH3, what was added and why? |
|
Definition
Added a strong acid to increase ph because we were too acidic |
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|
Term
When a strong base NaOH is added, what is result? |
|
Definition
R-Coo + H+ were too basic |
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|
Term
What is the ph of normal blood? |
|
Definition
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|
Term
What is blood ph in acidosis? |
|
Definition
less than 7.35 resulting in disorientation, coma, and death |
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|
Term
What is the blood ph in Alkalosis? |
|
Definition
Greter than 7.45 resulting in nerve twitches, muscle spasm, convulsions, death |
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|
Term
In Acidosis, what is respiratory response? |
|
Definition
Increases, hyperventilate |
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|
Term
In acidosis, what is urinary response? |
|
Definition
Reabsorbs Na+ and secretes H+ |
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|
Term
In Alkalosis, what is respiratory response? |
|
Definition
Breathing rate goes down and hypoventilate |
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|
Term
In Alkalosis, what is urinary response? |
|
Definition
Reabsorb Na+ and secrete K+ |
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|
Term
Which state, acidosis or alkalosis, is indicative of hyperventilation and secretions of H+ by urinary system? |
|
Definition
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|
Term
Which system is indicative of hypoventilating and secretion of K+ by urinary system? Acidosis or alkalosis |
|
Definition
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|
Term
Where is the basis of respiratory regulation of H+ concentrations? |
|
Definition
Medulla regulates by detecting H+ concentrations in CSF |
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|
Term
What is respiratory acidosis? |
|
Definition
Increase in acidity due to increased pCo2 in blood |
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|
Term
In respiratory acidosis, what is the detection and response? |
|
Definition
Detection: if pCO2 is greater than 45mmHG, increse in breathing rate to decrease acidity Response: acidity is increased due to increase inCO2 in blooe ..ex: emphazema |
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|
Term
What is respiratory alkalosis? |
|
Definition
decrease in acidity due to decreased CO2 in blood |
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|
Term
In respiratory alkalosis, what is the response |
|
Definition
Breathing rate slow to get more CO2 into blood to increase H in blood..oxygen deficiency and anxiety |
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|
Term
In respiratory alkalosis, what is the detection? |
|
Definition
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|
Term
What is Normal pCO2 range? |
|
Definition
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|
Term
What is the basis fo renal regulation of H+ concentration? |
|
Definition
kidney regulates by detecting HCO3- concentrations in filtrate |
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|
Term
What is normal HCO3- range? |
|
Definition
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|
Term
What is it called when there is an increase in acidity due to decreased HCO3- |
|
Definition
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|
Term
What is it called when there is a decrease in acidity due to increased HCO3-? |
|
Definition
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|
Term
How is metabolic acidosis detected? |
|
Definition
If HCO3- is less than 22mEq.L, blood pH less than 7.35 |
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|
Term
How i Metabolic Alkalosis detected? |
|
Definition
If HCO3- is greater than 28mEq/L and blood pH is greater than 7.45 |
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|
Term
In respiratory alkalosis, what is the detection? |
|
Definition
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|
Term
What is the solution for Metabolic AcidosisRenal pelvis |
|
Definition
Increase H+ to Na+ exchange by secreting H and reabsorbing Na |
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|
Term
What is the solution for Meabolic Alkalosis? |
|
Definition
Increase K+ to Na+ exchange, excrete HCO3- and reabsorm Na and secrete k |
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|
Term
What are the 4 organs of the urinary system? |
|
Definition
kidneys, ureter, bladder and urethra |
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|
Term
|
Definition
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|
Term
What organ filters blood plasma, water and solutes go to blood stream and rest is excreted? |
|
Definition
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|
Term
What organ transports urine? |
|
Definition
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|
Term
What organ gets rid of urine? |
|
Definition
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|
Term
What are the 3 urinary system controls? |
|
Definition
Filtration, reabsorption and secretion |
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|
Term
Describe reabsorption in urinary system controls |
|
Definition
Water and solutes go into blood from kidney |
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|
Term
Describe filtration and filtrate urinary system control. |
|
Definition
Filtration- plasma enters kidney Filtrate-what leaves the plasma |
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|
Term
When does secretion take place in urinary system controls? |
|
Definition
When materials are added from plasma to formed filtrate |
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|
Term
|
Definition
behind peritoneum kidneys and ureters |
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|
Term
What are the approximate dimensions of the kidney? |
|
Definition
4-5" long, 2-3" wide, and 1" thick |
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|
Term
Describe the location of the kidneys |
|
Definition
T12 to L3 right slightly lower than left due to liver |
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|
Term
Why is the right kidney lower than the left? |
|
Definition
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|
Term
What is the Hilus part of the Kidney? |
|
Definition
Notch in center where ureter and blood vessels leave the kidney |
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|
Term
What are the 3 layers around the kidney? |
|
Definition
Renal capsule, adipose capsule, renal fascia |
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|
Term
On the internal part of the kidney, what is the cavity for urine called? |
|
Definition
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|
Term
In the internal part of the kidney, what part collects filtrate from major calyces? |
|
Definition
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|
Term
Where are the Renal columns in the internal kidney? |
|
Definition
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|
Term
What part of the internal kidney is responsible for draining minor calyces? |
|
Definition
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|
Term
What part of the internal kidney is responsibleto drain collecting tubules? |
|
Definition
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|
Term
What shape are the renal medullary pyramids? |
|
Definition
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|
Term
Wher is the Medulla in the internal cortex of kidney? |
|
Definition
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|
Term
The collecting tubules and renal papillae are located in what part of the internal kidney? |
|
Definition
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|
Term
What part of the renal medullary pyramids is at the base of the pyramids, point towards the pelvis and run into the minor calix |
|
Definition
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|
Term
What does the renal pelvis do? |
|
Definition
Collects filtrate from major calyces |
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|
Term
What do the minor calyces do? |
|
Definition
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|
Term
Where does urine travel in teh renal medullary pyramids |
|
Definition
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|
Term
What are the dimensions of the ureters? |
|
Definition
10 to 12", connecting from kindney hlus to trigone of bladder |
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|
Term
What are the 3 layers of the ureters? |
|
Definition
Mucosa, muscularis, and fibrous coat anchorage |
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|
Term
What does the mucosa layer do in the ureter? |
|
Definition
Keeps urine off tranisitonal epithelium |
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|
Term
What layers of teh ureters are teh 2 layers on top, 3 layers near blader for peristalsis? |
|
Definition
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|
Term
What layer of ureters is adventitia, blood vessels, lymphatic vessels and nerves? |
|
Definition
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|
Term
What is the size of the urinary bladder? |
|
Definition
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|
Term
Where is the male urinary bladder? |
|
Definition
posterior to symphysis pubis |
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|
Term
Where is the female urinary bladder? |
|
Definition
anterior to vagina and inferior to uterus |
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|
Term
What is the structure of the urinary bladder? |
|
Definition
Trigone-triangular area that points anteriorally |
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|
Term
What is the structure of the urinary bladder? |
|
Definition
Trigone-triangular area that points anteriorally |
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|
Term
Where are the ureter openings? |
|
Definition
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|
Term
Where is the urethra opening? |
|
Definition
|
|
Term
What are the 4 layers of the urinary bladder? |
|
Definition
Mucosa, submucosa, muscularis, serous coat |
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|
Term
What part of the urninary bladder is from internal and external sphnicters? |
|
Definition
Muscularis (Detrusor muscle) |
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|
Term
What does the Mucosa do in the urinary bladder? |
|
Definition
Keeps urine off the transitional epithelium |
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|
Term
Describe the serous coat of the urinary bladder. |
|
Definition
Peritoneum-anchorage-continuous with adventitia from ureter |
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|
Term
What type of tissue is the Submucosa in the urinary bladder? |
|
Definition
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|
Term
What size is the urethra in males and females? |
|
Definition
Males 8" and Females 1.5" |
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|
Term
What are the 3 regions of the urethra in males? |
|
Definition
EPITHELIUM-prostatic transitional to MEMBRANOUS-pseudostratified to SPONGY-pseudostratified to opening stratified squamous |
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|
Term
What are the 3 coats of the urethra in females? |
|
Definition
mucosa, submucosa, muscularis |
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|
Term
In the female urethra, what type of epithelium is found? |
|
Definition
Transitional epithelium becomes stratified squamous |
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|
Term
What is the path of the urine through the kidneys to urethra? |
|
Definition
Glomerulus-Bowmann's capsule-Proximal convoluted tubule-Descenting loop of Henle-Ascending loop of Henle-Distal convoluted tubule- Collecting tubule (Renal pyramids)-Minor Calyx- Major Calyx-Renal pelvis- Ureter-Bladder-Urethra |
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|
Term
What is the path of the blood supply of the kidney? |
|
Definition
Renal artery-segmental (lobar) arteries enter hilus-interlobar arteries -afferent arteriole-capillaries (glomerulus)-efferent arteriole- peritubular capillaries (convoluted tubules) and or vasa recta (loop of Henle) interlobular vein (leave cortex)-arcuate vein- interlobar vein- renal vein |
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|
Term
Where is the glomerlus capillary? |
|
Definition
Between 2 arteriols- Afferent and Efferent |
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|
Term
What is the function of the nephron and how many do we have? |
|
Definition
Over 1 million-function is to filter blood, remove toxins, form urine |
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|
Term
What is the definition of the nephron? |
|
Definition
Microscopic functional unti of kidney |
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|
Term
What are the 2 types of nephron? |
|
Definition
Cortical and Juxtamedullary |
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|
Term
Which part of the nephron is shorter loop o fhenle in the outer region? |
|
Definition
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|
Term
What part of the nephron has corpuscles that are near the cortes and lop of helnle that goes down into medulla/pyramids? |
|
Definition
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|
Term
What do the long loops of Henle allow? |
|
Definition
enable urine to be diluted or concentrated |
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|
Term
The nephron consists of the glomerulus. What is th definition of the glomerulus? |
|
Definition
Finestrated capillarie 1,000 times as porous than other types of capillaries |
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|
Term
What are the two types of arterioles in the glomerulus? |
|
Definition
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|
Term
Which arteriole has angio tension and can constrict? |
|
Definition
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|
Term
Which arteriole has a vaso constricting substance? |
|
Definition
Afferent arteriole of Glomerulus |
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|
Term
Which aretriole comes out of glomerulus and drains glomerulus-branches into peritubular capillaries for absorption- low pressure? |
|
Definition
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|
Term
Which arteriold goes into glomerulus, feeds glomerulus. Has high resistance and high blood pressure and forces solutes and fluid out of blood into capsule? |
|
Definition
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|
Term
Which arteriole comes out of glomerulus? |
|
Definition
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|
Term
Which arteriole goes into glomerulus? |
|
Definition
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|
Term
What is a double walled cup that lies in the cortex of kidney- (visceral and parietal walls) |
|
Definition
Bowmann's Glomerular capsule |
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|
Term
What is the function of the bowmann's Glomerular capsule? |
|
Definition
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|
Term
What is the renal corpuscle made of? |
|
Definition
Composed of glomerulus and Bowmann's capsule |
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|
Term
|
Definition
Proximal Convoluted tubule |
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|
Term
Waht is the function and structure of the PCT-Proximal convoluted Tubule? |
|
Definition
Function- reabsorption of most of the water-begins to absorb the Na and s100% sugar- cuboidal epithelium with a brush border of micro villi |
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|
Term
Waht is the loop for countercurrent eschange that is simple squamous? |
|
Definition
Loop of Henle- ascending and descending |
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|
Term
What is absorbed in loop of Henle? |
|
Definition
Restof Na, water, and chloride |
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|
Term
|
Definition
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|
Term
In the DCT-distal convoluted tubule, what does it do? |
|
Definition
Fine tune water, elecrolyte cuboidal absorption |
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|
Term
What hormones and receptors are in the DCT-distal convoluted tubule? |
|
Definition
Alsosterone and ADH sensitive receptors |
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|
Term
Waht two types of cells are in the DCT? |
|
Definition
principle and intercallated |
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|
Term
If in acidosis, what does the DCT secrete? |
|
Definition
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|
Term
In the collecting tubule, what hormone is active? |
|
Definition
Aldosterone and ADH sensitive- ADH active in this tubule an some aldosterone |
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|
Term
What is the JGA Juxtaglomerular apparatus? |
|
Definition
DCT contacts the afferent arteriole which serves a renal corpuscle |
|
|
Term
What organ is the Macula densa part of? |
|
Definition
Juxtaglomerular apparatus JGA |
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|
Term
What does the Macula densa in the JGA do? |
|
Definition
Macula densa-modified cells of DCT sense osmolarity of filtrate |
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|
Term
Are the Juxtaglomerular cells part of the afferent or efferent arteriole? |
|
Definition
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|
Term
What do teh Juxtaglomerular cells do? |
|
Definition
Smooth muscle cells-sense changes in blood volume |
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|
Term
Where are renin granules? |
|
Definition
|
|
Term
Is vasoconstricting substance absorbed or released in teh JG cells? |
|
Definition
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|
Term
What does the Glomerular ENDOTHELIUM do and what is the structure? |
|
Definition
Fenestrated poores are 50 to 100 nm- restricts passage of blood cells |
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|
Term
Waht does the basement membrand of glomerulus- parietal layer of capsule do? |
|
Definition
Restricts passage of proteins |
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|
Term
Whicpart of endothelial capsular membrand restricts passage of blood cells |
|
Definition
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|
Term
Which part of endothelial capsular membrand restricts passage of proteins? |
|
Definition
Basement membrand of glomerulus |
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|
Term
Where is the capsular space in basement membrane of glomerulus? |
|
Definition
Between parietal and visceral capsule layers |
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|
Term
|
Definition
specialized cells which contain numerous pedicels |
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|
Term
Where are filtration slits of podocytes? |
|
Definition
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|
Term
What do th podocytes restrict |
|
Definition
Passage of medium sized proteins |
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|
Term
What are the 3 structural features of Renal Corpuscles which increse the filtration rate? |
|
Definition
-Blood pressure of capillaries- -Lenght of glomerular capillaries -Endothelial capsular membrand |
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|
Term
How do the blood pressure capillaries increase the glomerular filtration rate? |
|
Definition
Afferent arteriold diameter larger than efferent arteriole, results in higher blood pressure than other capillary beds |
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|
Term
What structureal featur of the renal corpuscles that increases filtration rate has a vast surface area? |
|
Definition
Length of glomerular capillaries |
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|
Term
Describe the endothelial capsular membrane of renal corpuscles. |
|
Definition
very thin- 1000 x as porous- finestrated- 50 times leakier |
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|
Term
What is the NFP- net filtration pressure determined by? |
|
Definition
|
|
Term
What is GBHP-Glomerular blood hydrostatic pressure? |
|
Definition
Hydrostatic 60 mmHg, form blood towards capsule -promotes filtration |
|
|
Term
What is CHP Capsular Hydrostatic Pressure? |
|
Definition
15mmHG goes back toward blood and opposes filtration |
|
|
Term
What is BCOP- Blood Colloid Osmotic Presure? |
|
Definition
30mmHg goes back toward blood and opposes filtration |
|
|
Term
Which promotes filtration: GBHP, CHP, BCOP |
|
Definition
|
|
Term
Which opposes filtration-GBHP, CHP, BCOP |
|
Definition
CHP and BCOP Capsular Hydrostatic Pressure and Blood Coloid Osmotic Pressure |
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Term
What is the Net Filtration Pressure? |
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Definition
18mmHg from blood to capsule that is 2x that of other capillary regions |
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Term
How much pressure is needed for Net filtrtion pressure to happen? |
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Definition
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What is the Filtration Fraction: |
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Definition
16 to 20% of plasma centrs the nephrons |
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Term
Is the Glomerular Filtration Rate directly proportional to the NFP Net Filtration Pressure? |
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Definition
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Term
When the blood pressure increases, does the Glomerular Filtration Rate increase of decrease? |
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Definition
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Term
Whan degydration decreases blood pressure, what happens to the Glomerular Filtration Rate/ |
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Definition
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Term
How much urine is excreted per day? |
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Definition
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Term
How much volume is filtered per minute? |
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Definition
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Term
how much volume is filtered per day? |
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Definition
180 liters or 48 gallons 60x the blood volume |
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Term
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Definition
Daily urine output of less than 50 mL/day |
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Term
What is Glomerulonephritis? |
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Definition
Nehpropathy ound in HIV, diabetes, hypertension, fibrosis of lomerulus, extracellular build upof fibers increasing diffusion distance (distupting efficiency of exchange- TGF-bets-transforming growth factor-increased levels in damaged tissues |
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