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Bio Final Fall '11
Chapters 1-19
53
Biology
Undergraduate 3
12/06/2011

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Term
Adenylyl Cyclase
Definition
Enzyme produces cAMP from ATP and inhibited by extracellular glucose. EG is high, Intracellular cAMP are low, vis-versa.
Term
Calcium (CA +2)
Definition
Second Messenger, binds to calmodulin receptor. CA2+/CAl activates proteins.
Term
Cyclic AMP (cAMP)
Definition
Synthesized when glucose is decreased, is a regulatory molecule, gives green light for CAP+ to go.
Term
Dephosphorylation
Definition
removal of phosphate of proteins
Term
phosphorylation
Definition
addition of phosphate group to a substrate. Exergonic ADP electrons and phosphate group have less potential energy than in ATP
Term
plasmodesmota
Definition
The connection between the cytoplasm of adjacent cells in plants. Have proteins that regulate passage of specific proteins. Communication portals
Term
Gap junctions
Definition
Structures in animal tissues that connect adjacent cells. Specialized proteins create channels between cells allowing water, ions, and small molecules like amino acids, sugars, and nucleotides to move.
Term
Hormones
Definition
Information carrying molecules that are secreted from aplant or animal cell, circulates in the body, and act on target cells far from the original cell that sent the signal. Bind to receptor molecules
Term
Signal Reception
Definition
Hormone bind to receptor. Identical Receptors allow for long distant signals to coordinate. They are dynamic (sensitivity change over time), and can be blocked (beta blocker)
Term
Lipid-soluble signals
Definition
receptors respond to them inside cell, because they readily diffuse through plasma membrane
Term
Signal Receptor
Definition
protein t hat changes its shape and activity after binding to a signal molecule. physical conformation is changed when a hormone binds to them.
Term
signal transduction
Definition
converts an intercellular signal to an intracellular signal. (extracellular to intracellular)
Term
signal transduction pathway
Definition
intercellular signal binds to receptor protein in membrane, signal trandsuction, signal amplification, and signal response in nucleus to target gene DNA
Term
G-proteins
Definition
Peripheral membrane proteins. When activated by signal receptor, they trigger signal transduction. They link the receipt of an extracellular signal to production in tracellular signal. Bind GTP and GDP. Activated when bound to GTP, inactivated when phosphate group leaves GDP
Term
G-proteins
Definition
Peripheral membrane proteins. When activated by signal receptor, they trigger signal transduction. They link the receipt of an extracellular signal to production in tracellular signal. Bind GTP and GDP. Activated when bound to GTP, inactivated when phosphate group leaves GDP
Term
Second Messenger
Definition
non protein signaling molecule that elicits a response to the first messenger.( signal arrived at cell surface)
Term
primary messenger
Definition
signal that arrived at cell surface involved with G proteins.
Term
Causes of Disease
Definition
bacteria(prokaryotes)
Genetic Mutations/Disorders-point mutation,aneuploidy
Viruses-Common cold, flu, sars, HIV
prions-Mad Cow
Term
point mutation
Definition
single base change (base pair substitution) DNA polymerase inserts wrong base as it synthesizes new strand of DNA, causes variation in color.
Term
Nondisjunction
Definition
Meiotic error where both homolgs or both sister chromatids move to the same pole of the parent cell, produces abnormal chromosome number. Gametes end with 2 copies or no copies of particular chromosome.
Term
Meiosis with no Mistakes?
Definition
1. chromosome in each homologous pair must seperate from each other during first meiotic division, so that one homolog ends up in each daughter cell.
2. Sister chromatids must seprate from each other and move to opposite poles of dividing cell during meiosis 2.
Term
Aneuploidy
Definition
offspring have abnormal number of particular chromosomes, 2 many or 2 few. (without-form) Results form the fertilization of gametes in which nondisjunction occurs.
Term
trisomic
Definition
zygote with 3 copies of the same chromosome. Down syndrome. "21"
Term
monosomy
Definition
zygote with one copy of the same gene. 2n-1
Term
Down Syndrome
Definition
1 in 700, or 1 in 666. extra copy of chromosome 21. trisomy. Mistake during meiosis in one of the parents.
Term
Polyploidy
Definition
More than 2 complete sets of chromosomes. common in plants, rare in animals. Salmon and trout have 4 sets.
Term
Triploid
Tetraploid
Octaploid
Definition
Banana
Corn
Strawberry
Term
Viruses
Definition
Not Cells.small infectious particles consisting of nucleic acids enclosed in a protein coat, and sometimes, a membranous envelope. Not alive because lack five attributes of life. Enter host cell, use their machinery
Term
Viral Genome
Definition
DNA or RNA virus, can be single or double stranded
Term
capsid
Definition
protein shell built from protein subunits called capsomeres
Term
capsomere
Definition
protein sub units that enclose viral genome and make up the capsid protein shell
Term
viral envelope
Definition
Some viruses have this and surround hte capsids of influenze viruses and many other found in animals. Derived from host cell membranes, and contain virus and host cell molecules.
Term
Viruses pt.2
Definition
reproduce only in host cells. packaged set of genes. lack metabolic enzymes and ribosomes for making proteins.
Term
The Lytic cycle
Definition
attachment, entry of phage DNA and degradation of host DNA, synthesis of viral genomes and proteins, assembly, and release.
Term
retroviruses
Definition
viruses that reverse transcribe their genome. RNA back to DNA. HIV.
Term
reverse transcriptase
Definition
the genome is first transcribed from RNA to DNA by this iral enzyme. an enzyme that is a DNA polymerase that makes a single stranded complementary DNA from a single RNA template. It removes the RNA strand and catalyzes the synthesis of a complementary DNA strand.
Term
prions
Definition
slow acting, virtually indestructable infectious proteins that cause brain disease in mammals. converte normal proteins into prion versions. stanley prusiner.10 to 20 year latency.convert other proteins to same structure.
Term
PrPc
Definition
normal prion protein, found on membrane of multiple tissues ( bind copper molecules)
Term
PrPc
Definition
normal prion protein, found on membrane of multiple tissues ( bind copper molecules)
Term
PrPsc
Definition
infectious, misfolded form PrPc.responsible for formation of amyloid plaques that lead to neuro degeneration
Term
Prions pt. 2
Definition
destroy them by denaturing proteins, resist to heat and radiation, protease enzyme activity
Term
basic pathway of gene expression in eukaryotic cell
Definition
transcription in nucleus, transcription in cytoplasm
Term
histone
Definition
proteins that are responsible for first level of DNA packing in chromatin
Term
epigenetic inheritence
Definition
inheritance of traits by mechanisms that do not involve changes in nucleotide structures.
Term
epigenenome
Definition
above the genome
Term
histone acetylation
Definition
mechanism for DNA packaging, positive control, activation of genes through binding of a regulatory protein and unpacks DNA and opens it for transcription. cooh3-
Term
histone methylation
Definition
mechanism for dna packaging, methyl groups, ch3 activation or inactivation. attached to histone protein tails
Term
histone tails
Definition
protrude outward that are accessible for chemical modification
Term
Epigenetics Link
Definition
link between environment and disease
Term
Vinclozolin
Definition
fungiside used on grapes and other fruits. anti-androgen. cause decrease in sperm and motility in next 4 generations in rats
Term
hereditary
Definition
transmission of traits from one generation to the next
Term
hereditary
Definition
the transmission of traits from one generation to the next
Term
variation
Definition
shows that offspring differ somewhat in appearance from parents and siblings
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