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James Watson and Francis Crick |
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Definition
Introduced an elegant double-helical model for the structure of DNA.
(Kidna stole it from the Franklin girl) |
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Definition
directs teh development of biochemical, anatomical, physiological and (to some extent) behavioral traits |
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DNA in heridty was first discovered... |
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Definition
by studying bacteria and the viruses that infect them |
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Frederick Griffith in 1928 |
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Definition
- worked with two strains of a bacterium, one pathogenic and one harmless
- Mixed heat-killed remains of the pathogenic strain with living cells of the harmless strain, some living cells became pathogenic. |
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Now defined as a change in genotype and phenotype due to assimilation of foreign DNA |
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Oswald Avery, Maclyn McCary and Colin MacLeod |
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Definition
- Announced that the transforming substance was DNA
- Conclusion was based on experimental evidence that only DNA worked in transforming harmless bacteria into pathogenic bacteria. |
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Term
Bacteriophages (or phages) |
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Definition
- Viruses that are widely used in molecular genetics research
- Helped further the study of DNA as a genetic material |
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Alfred Hersey and Martha Chase |
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Definition
- performed experiments showing that DNA is teh genetic material of a phage known as T2.
- Concluded that the injected DNA of the phage provides the genetic information |
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Definition
- Reported that DNA composition varies from one species to the next
- Chargaff's rule state that in any species there is an equal number of A and T bases, and an equal number of G and C bases |
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Maruice Wilkins and Rosalind Franklin |
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Definition
- Used a technique called X-ray crystallography to study molecular structure
- Franklin produced a picture of the DNA molecule using this technique |
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DNA's Crystallographic images |
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Definition
- Enabled Watcson to deduce that DNA was helical
- Enabled Watson to deduce teh width of the helix and the spacing of the nitrogenous bases
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Definition
Width suggested that the DNA molecule was made up of two strands |
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Definition
- T pairs up with A
- G pairs up with C
- Adenine and Guanine are double helicals
- Purine with a pyrimidine resulted in a uniform width consisten with the X-ray
- In DNA repication, the parent molecule unwinds, and two new daughter strands are built based on base-pairing rules
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