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BIO 355 - Human Genetics 03
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87
Science
Undergraduate 4
02/21/2012

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Term
Multifactorial
Definition
When more than one gene and the environment contribute to
the phenotype.
Term
Epigenics
Definition
Inheritance of traits transmitted by mechanisms not linked to the
DNA sequence.
Term
Cytogenetics
Definition
An area within the study of genetics that investigates the
morphology and location of genes.
Term
Chromatin
Definition
A long, thin, uncondensed form of DNA.
Term
Quaternary Structure
Definition
Interaction of two or more amino acid chains and also possible linkage with additional elements.
Term
Karyotyping
Definition
A technique in which chromosomes are stained, arranged in homologous pairs, and photographed to see if any chromosomes or chromosome pieces are missing.
Term
Purine
Definition
Adenine and guanine are 2 ring nitrogen bases known as ____.
Term
Gap 1
Definition
A specific time in the cell cycle when proteins are made and organelles are copied.
Term
Antiparallel
Definition
This term describes that the two sides of the ladder that is DNA run in opposite directions.
Term
Gamete
Definition
This type of cell is represented as either an egg or sperm in humans.
Term
Pseudohomologous
Definition
Because the X and Y chromosomes are not the same length and do not carry the same genetic information, but are still seen as a pair these chromosomes are termed ____.
Term
Concordance
Definition
When both twins have a particular trait it is called _________.
Term
Dizygotic
Definition
Fraternal twins are also called ___ twins.
Term
Cytokinesis
Definition
A period in cell division where a cleavage furrow forms and the cytoplasm divides
Term
Prader-Willi
Definition
A syndrome that occurs through paternal inheritance of a genetic error causing increased levels of gherlin and decreased mental capacity.
Term
Tay-Sachs
Definition
An error in a small organelle, which does not contain the proper digestive enzymes, can cause _____, a disease which causes death at an early age.
Term
Proteome
Definition
All of the proteins found in a particular cell.
Term
Transcription
Definition
A process that starts with a DNA molecule and ends with a functional mRNA molecule.
Term
Fetoscopy
Definition
A testing mechanism that uses a fiberoptic camera to see the developing child in realtime in the uterine cavity.
Term
Transmission Genetics
Definition
he branch of genetics dealing with inheritance patterns is called _______.
Term
Anaphase
Definition
A time when cohesin dissolves and the chromatids begin to separate as spindle fibers pull toward the poles.
Term
Telomere
Definition
The portion at the end of a chromosome that shortens with each nuclear division.
Term
Okazaki
Definition
The pieces made during DNA replication on the lagging strand are called ___ fragments.
Term
Peroxisome
Definition
The organelle, which helps to eliminate cellular destruction or toxicity when the intermediate by-product H2O2, is broken down, is __.
Term
Cyclins
Definition
A chemical group that are produced at a steady rate by a cell and at a specific concentration, allow activation of MPF.
Term
Huntington’s
Definition
A disease transmitted by a dominant gene that is neurodegenerative and leads to cognitive decline and loss of muscle coordination.
Term
Pedigree
Definition
The easiest way to analyze the transmission of a genetic trait in humans is through ___ analysis.
Term
Locus
Definition
A gene’s location on a chromosome is called its ___.
Term
Synthesis
Definition
A time in the cell when DNA replicates, resulting in 92 molecules of DNA.
Term
Poly-A Tail
Definition
A __ is added at the 3’ end to add stability to mRNA during post-transcriptional processing.
Term
Discordance
Definition
When only one twin has a particular trait it is called _________.
Term
Chromatid
Definition
One half of a replicated chromosome is called a __.
Term
Prophase
Definition
The first phase of mitosis when the nuclear membrane breaks down and centrioles move to the poles of the cell.
Term
Ligase
Definition
The enzyme responsible for sealing fragments together during DNA replication of the lagging strand.
Term
Polysome
Definition
When several ribosomes associate with one mRNA strand allowing the same amino acid chain to be made simultaneously it is called a ___.
Term
Acrocentric
Definition
A chromosome with the centromere placed near one end is labeled __.
Term
Phenylketonuria (PKU)
Definition
A disease in which an amino acid cannot be digested leading to brain cell death and eventual death if diet is not changed.
Term
RNA Polymerase
Definition
An enzyme that allows proper nucleotide bonding during transcription is ______.
Term
Human Growth Hormone (HGH)
Definition
A genetically engineered product that can be given to children who are not growing as they should is _____.
Term
Promoter region
Definition
An area upstream of the gene where transcriptional factors bind to DNA’s template strand.
Term
Promoter region
Definition
If a cell does not pass the gap one checkpoint it goes into __, a non-dividing, resting state.
Term
Leading strand
Definition
This strand can replicate continuously during DNA replication.
Term
Aneuploid
Definition
A(n) __ cell does not have a true number of chromosomal sets.
Term
Polar body
Definition
The actual structure tested when testing a female gamete as to not destroy the egg.
Term
Hemoglobin
Definition
A protein found in red blood cells composed of 2 α and 2 β chains as well as 4 iron elements.
Term
Mitochondria
Definition
An organelle in human cells containing its own DNA.
Term
Translation
Definition
The process of creating an amino acid chain through actions at a ribosome.
Term
Centromere
Definition
An area where DNA wraps differently and where sister chromatids are held together is called the ___.
Term
Secondary structure
Definition
Alpha helix, beta pleating, and gamma turns are examples of __.
Term
Insulin
Definition
The first hormone developed through genetic technology, which allows many individuals to live longer and with improved quality of life, is __.
Term
Mendel
Definition
_____ is the scientist who discovered that parents give “factors” to their offspring as a result of his studies of pea plants.
Term
Haploid
Definition
A sex cell is __ because it has N number of chromosomes.
Term
Anticodon
Definition
tRNA contains an acceptor stem and a(n) __ sequence.
Term
Primase
Definition
This enzyme helps to create the workbench by allowing the RNA primer to be created.
Term
Pyrimadine
Definition
One ring nucleotide bases like cytosine and uracil are called ___.
Term
Hereditarianism
Definition
The idea that a person develops in a certain fashion solely because of his/her genetic material is termed _____.
Term
Chargaff
Definition
The scientist who developed the rules that A+G=T+C, A=T, and G=C.
Term
3’
Definition
The end of the DNA molecule with an exposed sugar is called the __ end.
Term
Maturation Promoting Factors (MPF)
Definition
These start mitosis by helping to dissolve the nuclear membrane, condense the nucleotide sequence and begin spindle fiber formation.
Term
Homologous chromosomes
Definition
__ carry the same genetic information and are the same length.
Term
Diploid
Definition
Because a body cell has the 2N number of chromosomes it is referred to
as ________.
Term
DNA Polymerase
Definition
Facilitates proper complimentary base pairing during DNA replication.
Term
Methylated cap
Definition
This structure is added to the 5’ end of mRNA during post-transcriptional processing.
Term
Smooth ER
Definition
An organelle that produces phospholipids and steroids, detoxifies poisons and drugs, and helps regulate calcium ions is the _____.
Term
Ribosome
Definition
This tiny organelle is the site of formation of an amino acid chain during translation.
Term
Lagging strand
Definition
During DNA replication, this cannot be replicated continuously because of the limitations of DNA polymerase.
Term
Nucleosome
Definition
As DNA winds around histones, the structure formed by 8 wound histones is a(n) _____.
Term
Newborn Testing
Definition
________ is done soon after a child’s birth and tests for things that are fixable with medication or diet like PKU.
Term
Angelman
Definition
A syndrome that occurs through maternal inheritance of a genetic error causing increased euphoric, spastic movements and decreased mental capacity.
Term
Autosomes
Definition
Chromosomes 1 through 22 are known as the ___.
Term
Ultrasound
Definition
The type of testing done throughout a woman’s pregnancy that came out of sonar technology and is extremely safe is ________.
Term
Telophase
Definition
A time in the cell when the spindle fibers break down, the nuclear membrane begins to form again, and the chromosomes have finished moving.
Term
Chromosome
Definition
Shortened, condensed DNA molecules are called ___.
Term
Mitosis
Definition
__ involves division of a cell’s genetic material for growth and repair.
Term
Somatic
Definition
A diploid cell with 2N chromosomes is known as a ___ cell.
Term
Replicated
Definition
A chromosome made up of 2 sister chromatids is said to be __.
Term
Monozygotic
Definition
Identical twins are said to be ___ because they are created from a single zygote.
Term
Polygenic
Definition
When more than one gene contributes to a phenotype that phenotype is said to be ___.
Term
Amniocentesis
Definition
A testing method during which a sample of the amniotic fluid is taken out of the mother for further testing.
Term
Metaphase
Definition
A time in the cell when the chromosomes align at the equator due to spindle fiber action.
Term
Centrioles
Definition
Pairs of these help to organize a cell’s microtubular structures.
Term
Helicase
Definition
This enzyme breaks hydrogen bonds.
Term
Codon
Definition
This three base sequence can be found on a functional mRNA molecule.
Term
Gap 2
Definition
During this time, a cellular inventory is taken and the checkpoint following this time regulates passage into mitosis.
Term
Peptide
Definition
The type of bond that forms between neighboring amino acids.
Term
Molecular genetics
Definition
The process of __ allows researchers to study gene products and the actions of these products.
Term
DNA Replication
Definition
The process that occurs during synthesis.
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