Term
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Definition
river of life blood carries the "vital force" life sustaining fluid |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
functions of the circulatory system |
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Definition
transport protection regulation |
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Term
blood functions in transport - explain |
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Definition
transports O2, CO2 and nutrients to body cells, metabolic wastes to kidneys, hormones to target cells, stem cells from bone marrow and other origins to tissues where they lodge and mature |
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Term
blood functions in protection from infection and blood loss - explain |
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Definition
inflammation WBC antibodies and complement proteins platelets |
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Term
|
Definition
mechanism for limiting spread of infection |
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Term
how do WBC protect from infection |
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Definition
destroy pathogens and cancer cells |
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Term
how do antibodies and complement proteins protect |
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Definition
neutralize toxins and pathogens |
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Term
|
Definition
initiate clotting and minimize blood loss |
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Term
blood functions in regulation |
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Definition
by absorbing or giving off fluid stabilize fluid distribution buffers acids and bases in blood thus stabilizing pH shift in flow regulate body temp |
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Term
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Definition
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Term
what is the matrix of blood? (not fluid) |
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Definition
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Term
what are formed elements? |
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Definition
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Term
what are 3 formed elements |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
what are 2 categories of leukocytes |
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Definition
granulocyres agranulocytes |
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Term
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Definition
neutrophils eosinophils basophils |
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Term
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Definition
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Term
what is it called when one separates formed elements from plasma |
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Definition
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Term
straw color top part of centrifuged blood |
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Definition
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Term
what is the buffy coat of centrifuged made of |
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Definition
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Term
what are packed at the bottom and red of centrifuged blood |
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Definition
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Term
what are the densest formed elements |
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Definition
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Term
45% of total volume of blood |
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Definition
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Term
what is a mixture of dissolved nutrients, gases, hormones, waste, enzymes and proteins |
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Definition
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Term
what is a mixture of water, proteins, nutrients, electrolytes, nitrogenous wastes, hormones, gases |
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Definition
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Term
what is plasma minus fibrinogen |
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Definition
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Term
what are the most abundant plasma solute |
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Definition
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Term
3 major categories of plasma proteins |
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Definition
albumin globulin fibrinogen |
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Term
most abundant protein in the plasma |
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Definition
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Term
what protein serves to transport solutes and buffer pH |
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Definition
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Term
what are albumins a major contribution to |
|
Definition
viscosity - thickness osmolarity - how many solids are in the blood |
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Term
what do changes in albumin concentration cause |
|
Definition
significantly affect blood volume, blood pressure and blood flow |
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Term
|
Definition
osmotic pressure blood viscosity transport lipids, hormones, Ca and buffers pH |
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Term
what are 3 subclasses of globulins |
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Definition
alpha globulins beta globulins gamma globulins |
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Term
2 examples of alpha globulins |
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Definition
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Term
function of ceruloplasmin |
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Definition
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Term
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Definition
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Term
functions of other alpha globulins |
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Definition
transport lipids, fat souble vitamins and hormones |
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Term
2 examples of beta globulins |
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Definition
transferrin complement proteins |
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Term
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Definition
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Term
function of complement proteins |
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Definition
aid in destruction of non-specific toxins and pathogens |
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Term
2 other names for gamma globulins |
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Definition
immunoglobulins antibodies |
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Term
|
Definition
specific proteins made by plasma cells that combat specific pathogens |
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Term
what does fibrinogen become |
|
Definition
fibrin - a major component of blood clots |
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Term
what produces all the major plasma proteins except gamma globulins |
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Definition
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|
Term
where are gamma globulins descended from |
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Definition
WBC's called B lymphocytes |
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Term
2 nitrogen-containing compounds are in plasma |
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Definition
amino acids nitrogoneous wastes |
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Term
toxic products of catabolism |
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Definition
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Term
most abundant nitrogenous waste |
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Definition
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Term
product of AAs catabolism |
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Definition
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Term
|
Definition
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|
Term
what nutrients does blood plasma transport |
|
Definition
AA, glucose, FA, glycerol, triglycerides, cholesterols, phospholipids, vitamins and minerals |
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Term
what electrolytes does blood plasma transport |
|
Definition
Na, Ca, K, Mg, Cl, HCO3, HPO4, SO4 |
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Term
what gases does blood plasma transport |
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Definition
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|
Term
the resistance of blood to flow resulting from cohesion of its particles |
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Definition
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|
Term
thickness or stickiness of blood |
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Definition
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Term
what decreases viscosity and causes blood to flow too easily |
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Definition
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Term
what increases viscosity and cause blood to flow too slow |
|
Definition
excesses of RBCs or proteins |
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Term
the total dissolved particles that cannot pass throught the BV wall |
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Definition
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|
Term
3 main contributors to blood osmolarity |
|
Definition
sodium ions proteins (albumins) RBCs |
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Term
the transfer of fluids depends on a balance between the ____ of fluid from the capillary and its movement back into the capillary by ____ |
|
Definition
filtration, reabsorption (osmosis) |
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Term
high blood osmolarity cause the blood to reabsorb ____ water and ____ BP thus straining heart and BV |
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Definition
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|
Term
low blood osmolarity cause the tissues to retain ____ fluid and become ____ and ____ BP thus straining heart and BV |
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Definition
too much, edematous, decrease |
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Term
production of blood and its formed elements |
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Definition
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|
Term
tissues that produce blood cells |
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Definition
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|
Term
during embryonic development stem cells colonize 4 things |
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Definition
bone marrow liver spleen thymus |
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Term
bone marrow, liver, spleen and thymus stem cells, during embryonic development, produce |
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Definition
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Term
after birth, what 3 things continue to produce lymphocytes for life |
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Definition
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|
Term
infancy onward, ___ produces all 7 kinds of formed elements |
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Definition
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|
Term
infancy onward, the thymus, tonsils, lymph nodes and spleen produce |
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Definition
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|
Term
blood formation in bone marrow |
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Definition
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|
Term
blood formation in lymphatic organs |
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Definition
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|
Term
most abundant formed element |
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Definition
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Term
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Definition
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|
Term
have a discoidal cell with biconcave shape |
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Definition
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|
Term
lack a nucleus and have a 120 day life expectancy |
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Definition
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|
Term
since RBC lacks a mitochondria, what does it rely on to produce ATP |
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Definition
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|
Term
cytoplasm of RBCs consist of |
|
Definition
hemoglobin CAH - carbonic anhydrase |
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|
Term
what enzyme catalyzes CO2+H2O<-->H2CO3 |
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Definition
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|
Term
plasma membrane of RBCs contain |
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Definition
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|
Term
what determines a persons blood type |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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|
Term
3 measurements of RBCs and hemoglobin |
|
Definition
hematocrit hemoglobin concentration RBC count |
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Term
whose RBC/hemoglobin values are lower, men or women |
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Definition
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|
Term
why are hemoglobin/RBC values lower in women than in men |
|
Definition
androgens stim RBC production women have periodic menstual losses hematocrit is inversely proportional to percentage body fat blood clots faster in men men have fewer BV near skin |
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|
Term
erythrocyte production called |
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Definition
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|
Term
8 steps in erythropoiesis |
|
Definition
1 hemopoietic stem cell becomes 2 erthryocyte colony-forming unit EFCU 3 ecfu have receptors for 4 erythropoietin (EPO) secreted from liver and kidney cells 5 EPO stimulates ECFU to become erythroblast that produce hgb 6 erythroblast lose nucleus and become reticulocytes 7 formation of reticulocytes (immature RBCs) are released from bone marrow into BV 8 day or twon, reticulocytes become mature erythrocyte |
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Term
hormone secreted from liver and kidney in response to low levels of O2 |
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Definition
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|
Term
stimulates bone marrow to produce RBC |
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Definition
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Term
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Definition
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Term
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Definition
kidneys and liver increase production and secretion of EPO which stimulates stem cells in bone marrow to increase RBC production |
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Term
|
Definition
low levels of atmospheric O2 increase in exercise hemorrhaging |
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Term
nutritional requirements for erythropoiesis |
|
Definition
B12 and folic acid - for rapid cell division and DNA synthesis Vit C and copper - cofactors for enzymes Iron - hemoglobin |
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Term
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Definition
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|
Term
____ in liver and spleen phagocytize worn out RBC |
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Definition
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Term
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Definition
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Term
old RBCs become trapped and break apart within the spleen is called |
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Definition
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|
Term
whats released when RBC breaks |
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Definition
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|
Term
what can block kidney tubules and cause renal failure |
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Definition
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|
Term
phagocytize and separates heme from globin |
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Definition
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|
Term
picks up iron that has been release from heme into blood |
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Definition
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|
Term
convert the leftover heme into biliverdin |
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Definition
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Term
|
Definition
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|
Term
bilirubin released from macrophage to ___ in the blood |
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Definition
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|
Term
liver removes ___ from albumin and secretes it into the ___ |
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Definition
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Term
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Definition
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Term
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Definition
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Term
|
Definition
rapid hemolysis liver disease bile duct obstruction |
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Term
|
Definition
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|
Term
gut bacteria converts bilirubin to ___ |
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Definition
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Term
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Definition
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|
Term
deficiency of either RBCs or hgb |
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Definition
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|
Term
3 dangers of polycythemia |
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Definition
increased BV increased BP increased blood viscosity |
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Term
results from dietary deficiency of any requirements for erythropoiesis |
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Definition
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|
Term
lack of iron in diet (tyoe of anemia) |
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Definition
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|
Term
deficiency of vitamin B12 (type of anemia) |
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Definition
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|
Term
failure of stomach to produce intrinsic factor (type of anemia) |
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Definition
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|
Term
blood types based on large molecules called |
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Definition
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|
Term
antigens can be 3 diff things |
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Definition
proteins glycoproteins glycolipids |
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|
Term
allows the body to distinguish its own cells from foreign cells with foreign antigens |
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Definition
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|
Term
plasma cells secrete ___ when immune response is activated bc the body detects a foreign antigen |
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Definition
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|
Term
bind to foreign antigens and mark the cell for destruction |
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Definition
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|
Term
each antibody binds to 2 or more foreign antigens and sticks them together in an antigen-antibody complex |
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Definition
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|
Term
all cells have ___ on the surface of their cell membrane |
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Definition
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Term
id's your RBCs as unique to you |
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Definition
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Term
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Definition
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|
Term
antibodies in the plasma for foreign RBCs |
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Definition
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|
Term
determined by hereditary with the presence/absence of antigen A and antigen B |
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Definition
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Term
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Definition
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Term
anti-B antibody in plasma |
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Definition
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Term
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Definition
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Term
anti-A antibody in plasma |
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Definition
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Term
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Definition
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Term
neither anti-A or anti-B antibodies in plasma |
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Definition
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|
Term
neither antigen A or B on RBC |
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Definition
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|
Term
both anti-A and anti-B antibodies in plasma |
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Definition
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|
Term
anti-A antibody is against antigen |
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Definition
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|
Term
anti-B antibody is against antigen |
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Definition
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|
Term
its the recipient's ___ that agglutinate the donor's ___ |
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Definition
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|
Term
the clumping of donated RBCs by recipients's antibodies |
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Definition
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|
Term
true/false. you have antibodies in your plasma that react against your antigens |
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Definition
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|
Term
in transfusion reaction, agglutinated RBCs can.... |
|
Definition
block small BV hemolyze and release hgb into the bloodstream |
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|
Term
free hemoglobin can block ... |
|
Definition
renal tubules leading to renal failure |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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|
Term
Rh+ has what antigen present on RBCs plasma membrane |
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Definition
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|
Term
Rh- does not have what antigen present on RBCs plasma membrane |
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Definition
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|
Term
are anti-D antibodies normally present in the blood plasma |
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Definition
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|
Term
|
Definition
Rh- person has received Rh+ transfusion
Rh- mother carrying Rh+ fetus |
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Term
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Definition
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|
Term
baby born with very few RBCs causes |
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Definition
erythroblastosis fetalis hemolytic disease of newborn |
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Term
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Definition
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|
Term
never has anti-D antibodies in plasma |
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Definition
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|
Term
does not have antigen D on RBC |
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Definition
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|
Term
|
Definition
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|
Term
does not have anti-D antibodies in plasma |
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Definition
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|
Term
how can Rh- blood be exposed to Rh+ blood |
|
Definition
transfusion carry Rh+ fetus |
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Term
|
Definition
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|
Term
abundant in the body tissue |
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Definition
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|
Term
all WBC squeeze out of BV and into CT to search and destroy anything foreign |
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Definition
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|
Term
|
Definition
defend body against foreign material bacteria, viruses, parasites, toxins, tumors, tissue/organ transplants |
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|
Term
WBCs must synthesize ___ to carry out their functions |
|
Definition
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|
Term
|
Definition
neutrophil basophil eosinophil lymphocyte monocyte |
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Term
|
Definition
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|
Term
found at site of bacterial infection |
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Definition
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|
Term
carry out phagocytosis of bacteria aka "bacteria slayer" |
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Definition
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|
Term
1st at the site of infection |
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Definition
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|
Term
|
Definition
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|
Term
granules contain lysosomes |
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Definition
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|
Term
secrete antimicrobial chemicals |
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Definition
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|
Term
line mucous membranes or respiratory, GI and urinary tract |
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Definition
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|
Term
increases during an allergic reaction and in a parasitic |
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Definition
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|
Term
release enzymes to destroy parasites such as worms |
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Definition
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|
Term
phagocytizes inflammatory chemicals and antigen-antibody complexes and allergens |
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Definition
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|
Term
|
Definition
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|
Term
secrete histamine/heparin |
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Definition
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|
Term
vasodilator and makes BV leaky |
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Definition
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|
Term
anticoagulant that inhibits blood clotting and increases mobility of other WBCs in the area |
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Definition
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|
Term
|
Definition
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|
Term
second to neutrophil in abundance |
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Definition
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|
Term
|
Definition
destroy cancer cells, virus infected cells, foreign cells, present antigens, coordinate actions of other immune cells, secrete antibodies, serve in immune memory |
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|
Term
differentiate in bone marrow |
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Definition
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|
Term
|
Definition
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|
Term
convert into plasma cells and secrete antibodies against pathogens |
|
Definition
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|
Term
set up the pathogen for destruction |
|
Definition
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|
Term
stimulate or inhibit other lymphocytes |
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Definition
helper T-cell suppressor T-cell |
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|
Term
kill virus infected cells, tumor cell, foreign cells, transplanted cells |
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Definition
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|
Term
|
Definition
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|
Term
|
Definition
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|
Term
levels increase during inflammation and viral infections |
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Definition
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|
Term
once monocyte leaves BV, they are called |
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Definition
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|
Term
|
Definition
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|
Term
destroy dead or dying host and foreign cells, pathogenic chemicals and pathogenic microbes by phagocytosis |
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Definition
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|
Term
"present" antigens to activate other cell of the immune system aka antigen presenting cells APC |
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Definition
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|
Term
|
Definition
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|
Term
bacterial infection triggers production of |
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Definition
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|
Term
allergy triggers production of |
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Definition
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|
Term
both B- and T-lymphocytes colonize in |
|
Definition
spleen lymph nodes lymphoid organs and tissues |
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|
Term
true/false circulating WBCs stay in bloodstream |
|
Definition
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|
Term
|
Definition
leukemia myeloid leukemia lymphoid leukemia |
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|
Term
cancer of hemopoietic tissue that produces high numbers of circulating leukocytes |
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Definition
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|
Term
uncontrolled granulocyte production |
|
Definition
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|
Term
uncontrolled lymphocyte or monocyte production |
|
Definition
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|
Term
what is the control of bleeding |
|
Definition
|
|
Term
|
Definition
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|
Term
mechanism for stopping leaks which could be potentially fatal |
|
Definition
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|
Term
platelets originate from... |
|
Definition
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|
Term
cell fragments that lack nucleus |
|
Definition
|
|
Term
|
Definition
1 secrete vasoconstrictors that stimulate spasmodic constriction of broken BV to reduce blood loss 2 stick together to form temp platelet plugs to seal small breaks in BV 3 secrete procoagulants or clotting factors 4 initiate formation of clot-dissolving enzyme 5 secrete chem to attract neutrophils and monocytes to sites of inflammation 6 internalize and destroy bacteria 7 secrete growth factors to stimulate fibroblast and SM to repair BV |
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|
Term
what is platelet production |
|
Definition
|
|
Term
___ stem cells produce receptors for hormone ___ and ___ are produced |
|
Definition
hemopoietic thrombopoietin megakaryocytes |
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|
Term
? break up into platelets |
|
Definition
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|
Term
what are stored in the spleen and released when needed |
|
Definition
|
|
Term
|
Definition
vascular spasm platelet plug formation blood coagulation |
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|
Term
prompt constriction of a broken vessel |
|
Definition
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|
Term
during vascular spasm platelets release |
|
Definition
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|
Term
a chemical vasoconstrictor |
|
Definition
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|
Term
|
Definition
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|
Term
significantly reduces blood loss and provides time for other 2 hemostatic mechanisms to work |
|
Definition
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|
Term
|
Definition
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|
Term
may reduce or stop minor bleeding |
|
Definition
|
|
Term
during platelet plug formation platelets release |
|
Definition
|
|
Term
an eicosanoid that promotes platelet plug formation and vasoconstriction |
|
Definition
|
|
Term
what inhibits thromboxane A2 |
|
Definition
|
|
Term
|
Definition
|
|
Term
most effective defense against bleeding |
|
Definition
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|
Term
true/false it is important for blood not to clot in an unbroken blood vessel |
|
Definition
|
|
Term
in coagulation, the objective is to convert ___ into ___ |
|
Definition
fibrinogen insoluble fibrin |
|
|
Term
a sticky protein that adheres to BV wall |
|
Definition
|
|
Term
blood cells and platelets stick to ___ resulting in a mass that seals the BV |
|
Definition
|
|
Term
|
Definition
procoagulants produced by liver |
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|
Term
when one clotting factor is activated, it functions as an ___ that activates the next clotting factor |
|
Definition
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|
Term
clotting factors activate one factor and that factor will activate the next to form a |
|
Definition
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|
Term
the last four procoagulants |
|
Definition
|
|
Term
nutrients needed for coagulation |
|
Definition
calcium vitamin k clotting factors |
|
|
Term
necessary substances for blood to clot |
|
Definition
|
|
Term
cofactor for clotting factors |
|
Definition
|
|
Term
needed for the production of clotting factors in the liver |
|
Definition
|
|
Term
after the blood clot has formed, platelets adhere to fibrin and contract; platelets pull fibrin like drawstring on purse in a process called |
|
Definition
|
|
Term
platelets and endothelial cells secrete |
|
Definition
platelet-derived growth factor PDGF |
|
|
Term
platelet-derived growth factor PDGF stimulates |
|
Definition
fibroblast and smooth mus cells to multiply and repair BV |
|
|
Term
once BV repaired, the clot must be |
|
Definition
|
|
Term
|
Definition
|
|
Term
tissue plasminogen activator TPA |
|
Definition
converts plasminogen to plasmin TPA = kallikrein |
|
|
Term
a fribin-dissolving enzyme that breaks up the clot |
|
Definition
|
|
Term
is plasmin a anticoagulant |
|
Definition
|
|
Term
true/false in platelet replulsion, platelets do not adhere to the smooth prostacyclin-coated endothelium of healthy BV |
|
Definition
|
|
Term
in dilution, small amts of ___ formed spontaneously in plasma |
|
Definition
|
|
Term
decrease in blood flow causes... |
|
Definition
thrombin to accumulate and clotting can occur can occur in cirvulatory shock |
|
|
Term
inhibited by anticoagulants in the plasma |
|
Definition
|
|
Term
secreted by liver that deactivates thrombin |
|
Definition
|
|
Term
anticoagulant secreted by basophils and mast cells |
|
Definition
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|
Term
blocks action of thrombin |
|
Definition
|
|
Term
given by injection to patients with abnormal clotting tendencies |
|
Definition
|
|
Term
examples of anticoagulants |
|
Definition
plasmin antithrombin heparin |
|
|
Term
examples of vitamin K antagonist |
|
Definition
|
|
Term
extract of sweet clover, tonka beans |
|
Definition
|
|
Term
|
Definition
|
|
Term
suppresses formation of eicosanoid thromboxane, factor in platelet aggregation |
|
Definition
|
|
Term
secrete hirudin that inhibits thrombin |
|
Definition
|
|
Term
organ that synthesizes most of the clotting factors |
|
Definition
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|
Term
liver requires what vitamin for synthesis of clotting factors |
|
Definition
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|
Term
manufactors and secretes bile which is necessary for the absorption of vitamin k |
|
Definition
|
|
Term
can obstruct secretion of bile and result in vitamin k not being absorbed in intestines |
|
Definition
|
|
Term
|
Definition
|
|
Term
thrombus that breaks away, floats in bloodstream and may lodge elsewhere |
|
Definition
|
|
Term
tissue death may occur brain, heart, lungs |
|
Definition
|
|
Term
widespread clotting within unbroken BVs |
|
Definition
disseminated intravascular coagulation DIC |
|
|
Term
DIC is usually triggered by |
|
Definition
|
|
Term
bacteria in the bloodstream |
|
Definition
|
|
Term
marked by widespread hemorrhaging, congestion of BV with clotted blood, and tissue necrosis in blood deprived organs |
|
Definition
disseminated intravascular coagulation DIC |
|
|
Term
|
Definition
immunoglobulins antibodies |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
3 main contributors to blood osmolarity |
|
Definition
sodium ions proteins (albumins) RBC's |
|
|
Term
another name for antigens |
|
Definition
|
|
Term
nutritional requirements for RBC production |
|
Definition
|
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Term
-emia on the end of the word means its dealing with what |
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during RBC production, ___ become mature RBC (erythrocyte) |
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macrophages in the ___ & ___ phagocytize worn out RBC |
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during hemolysis, what can happen if the HGB is not disposed of completely? |
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HGB can block kidney tubules and lead to renal failure |
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macrophages convert heme into |
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bilirubin is released from macrophage to ___ in the blood |
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___ removes bilirubin from albumin and secretes it into the bile. (organ) |
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gut bacteria converts bilirubin into ___ responsible for feces brown color |
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basophils try to do what to infection |
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___ count increases during allergic reaction |
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WBC that phagocytizes inflammatory chemicals |
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what are antigen presenting cells known as |
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platelets originate from what huge cell |
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what breaks RBC up into platelets |
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where are platelets stored til they are needed |
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what vitamin is needed for production of clotting factors in the liver |
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