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Bio 18
Regulation of Gene Expression
23
Biology
Undergraduate 1
11/07/2012

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Term
True or false: Nearly every cell contains every gene in the body.
Definition
True: Nearly every cell contains every gene in the body.
Term
What factors effect gene expression?
Definition
Cell type, developmental stage, environment.
Term
What causes  genes to turn on or off?
Definition
Enzymes (proteins), drugs, feedback mechanisms.
Term
Operon
Definition
A gene and the regulatory regions that control if the gene is made into a polypeptide.
Term
Operator
Definition
The DNA segment in the promoter region that acts as an on/off switch for gene expression.
Term
Repressor
Definition
A protein that switches genes off by binding to the operator, blocking Polymerase access to the promoter.
Term
What causes genes which are usually "on" to turn "off?"
Definition
When the product concentration is too high.
Term
What causes some genes that are usually "off" to turn "on?"
Definition
When the substrate is available.
Term
Substrate
Definition
A substance on which an enzyme acts.
Term
Activators
Definition
Proteins whose DNA binding stimulates transcription.
Term
Control of gene expression can occur through ______ ____________.
Definition
Chromatin structure.
Term
What things about chromatin structure effects gene expression?
Definition
How tightly coiled the DNA is, DNA methylation, Epigenetic inheritance.
Term
How does the tight coiling of chromatin effect gene expression?
Definition
It affects RNA Polymerase access.
Term
How does methylation effect gene expression?
Definition
CH3 added to bases can inactivate genes.
Term
Epigenetic Inheritance
Definition
Genetic factors unrelated to base sequences affecting traits.
Term
During what may gene expression be effected?
Definition
Transcription and translation.
Term
Enhancer
Definition
A protein binding region that influences the rate of transcription.
Term
What influences gene expression during transcription?
Definition
Whether proteins bind to Enhancers.
Term
mRNA stability
Definition
How resistant mRNA is to degradation from enzymes breaking it down.
Term
What effects gene expression during translation?
Definition
mRNA stability and micro mRNA
Term
What is mRNA stability based on?
Definition
The nucleotide sequence
Term
MicroRNA
Definition
Short mRNA sequences complimentary to a small part of mRNA.
Term
What does MicroRNA do?
Definition
It binds to mRNA, blocking translation and degrading the mRNA.
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