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Bio 123 Lecture 1
Infection and Immunity
35
Biology
Undergraduate 1
01/14/2013

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Term
symbiosis means living together and mutalism is a form of symbiosis. But do both organisms involved benefit or get harmed in this symbiosis?
Definition
in mutalistic symbiosis both organism 1 and 2 benefit. an example is bacteria in human colon
Term
Give an example of commensalism symbiosis and say whether the organisms involved benefit or get harmed.
Definition

example: staphylcoccus on skin. 

organism 1 : the staphylcoccus benefits but organism 2 : the skin neither benefits nor is harmed

Term
which symbiosis is tuberculosis bacteria in the human lung an example of?
Definition

paratism

organism 1:tubercolosis benefits

organism 2: human host is harmed

Term
parasites are infectious agents?
Definition
true they are infectious agents
Term
what 2 things must a parasite do in order to be a parasite?
Definition
it must cause HARM to their host and also be TRANSMITTED from one host to another to continue their life cycles
Term
which types of infectious agents typically cause acute infections?
Definition
viruses, bacteria and fungi
Term
which infectious agents cause chronic infections?
Definition

parasites

 

eg, protozoa and worms (helminths)

Term

what am i?

i live on the external surface of a host

Definition
ectoparasite
Term
im a parasite who lives within a host
Definition
endoparasite
Term
t/f an obligate parasite can complete its life cycle without its host?
Definition

False!

obligates parasites require a host to complete their life cycle

Term
im an organism thats not normally parasitic
Definition
facultative parasite
Term
name the host in which parasites reach sexual maturity
Definition

definative host

eg, mosquito for malarial plasmodium

Term
what is an intermediate host required for?
Definition

development of parasite

eg, humans for plasmodium

Term
i play no part in development just transport. what type of host am i?
Definition
Paratenic host
Term
i'm an animal that harbours a parasite ready to be transmitted to humans
Definition
Resevoir host
Term
disease processes:- name the 3
Definition

Invasion - entry and transmission

Multiplcation and spread

Pathogenesis

Term
the Ascaris worm is found in contaminated food and drink. how is it transmitted?
Definition
orally
Term
how does influenza virus enter the body?
Definition
inhalation
Term
how do HIV and malaria get into the body?
Definition
direct inoculation either via needle of drug user or mosquito needle
Term
how are schistosomes (worm) introduced to the body?
Definition
direct skin contact
Term

true of false?

intra-uterine routes of invasion include toxoplasma. 

Definition
true this is a route for toxoplasma into the human body
Term

true or false

all organisms can multiply when in the body?

Definition

false 

only some can eg, protozoa can multiply so can cause infection with only a few infectious stages

 

Worms cannot multiply within body so one or two couldnt cause disease

Term
how does the plasmodium parasite reproduce?
Definition
asexually
Term
name 2 ways which malaria causes pathogenesis?
Definition

direct killing of host cells

blockages within host organisms

Term
how does clostridium botulinum cause pathogenesis?
Definition
releases exotoxins
Term
how does schistosomiasis cause pathogenesis?
Definition
it affects the activity of the host immune system and causes cancer
Term
the biological response gradient is an iceberg concept of infectious diseases. What does this mean?
Definition
most people with diseases are asymptomatic. this is like the majority of the iceberg being beneath sea level
Term
the exact clinical picture of disease depends on 7 factors. What are they?
Definition

1. infection dose 2. route of infection

3. age of host 4. sex of host

5. presence of other microbes

6. nutritional status

7. genetic background

Term

burden of disease is measured by incidence.

what does incidence mean?

Definition
number of new cases of infection occuring in a population in a defined period of time
Term
what does prevalence of disease mean?
Definition
total number of infected individual in a population ie/ no' of new and old cases
Term
define parasitaemia
Definition
a condition where parasites are present in the blood
Term
define intensity of disease
Definition
the level of infection per individual (parasitaemia)
Term
what is the difference between mortality and  morbidity?
Definition

mortality - no of deaths per annum

morbidity - state of ill health

Term
how do we account for diseases that disable but do not kill?
Definition
Daily Adjusted Life Year (DALY)
Term
how is 1 DALY calculated?
Definition
adding together 'years lost to premature mortality' and 'years lost to disability'
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