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Type of cell division that results in two daughter cells -Each the same as the parent nucleus |
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-Somatic Cells -Contains both members of each pair of homologous chromosomes
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Contains only one member of each homologous chromosome pair
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(Terminally) Differentiated Cell |
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The normal process by which a less specialized cell develops or matures to possess a more distinct form and function. -Red blood cell: loses its nucleus in order to carry oxygen |
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-Any cell in the body of an organism/multicellular organisms. -There is growth/development and repair/renewal in cells |
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Eukaryotic Cell: Genetic Material |
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DNA + Histones = Nucleosome = become coiled i= Chromatin. Chromatin coils into Chromosomes. Chromosomes are in the nucleus of a cell.
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-10nm in diameter -DNA winds around a cluster of histone molecules -Linker DNA between histone molecules -Histone Tails present
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Organization of Eukaryotic Chromosome |
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Different levels. Nucleosome: 1st level. Chromatin formed in: 2nd level. Fibers looping: 3rd level.
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The series of events that takes place in a cell leading to its division and duplication (replication). Eukaryotic unique only, with nucleus present.
1) INTERPHASE- G1, S, G2. 2) M PHASE- Mitosis, Cytokinesis. |
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The longest part of the cycle (23 hours in mammalian species. Phase where cell gets ready to divide Consists of: G1, S, G2. |
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-The first growth phase in interphase -Cell synthesizes proteins and produces cytoplasmic organelles.. |
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-Synthesis phase -Main: DNA replication -Histone proteins are synthesized as well so that the cell can make duplicate copies of its chromosomes. |
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-Shorter in comparison to G1 and S phase -Increased protein synthesis occurs, -Final steps in the cell’s preparation for division -Right before mitosis/as it initiates, centrosomes move to opposite ends |
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-10% of cell division cycle -Consists of mitosis and interphase |
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-Mitotic spindles begin to form -Nuclear envelope breaks up -Chromatin begins to foil into chromatin, which are split into two sister chromatids -Kinetochores attach and form to centromeres |
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Part of the chromosome that links two sister chromatids together |
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-Protein structues attached to each centromere -Microtubules bind to them |
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-Spindle microtubules attach to the kinetochores of chromosomes/chromatids, -Attach chromosomes to the cell poles -Line chromosomes up at equatorial/metaphase plate -Nuclear envelope disappears |
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-Spindle poles move farther apart and the spindles pull the sister chromatids apart at their centromeres. Each daughter chromosome pulled towards one end. |
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They are within the centrosomes, and as the centrosomes split, a pair of centrioles are at each spindle pole -Spindle microtubules come out of centrioles |
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-Chromosomes grouped at poles -Nuclear envelope reforms -Cleavage furrow |
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-Cytoplasm pinching leads to a forming of a cleavage furrow (pinched by microfilaments as a ring contracts) -The cytoplasm splits on the furrow, forming two daughter identical daughter cells with nuclei each |
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In between prophase and metaphase When spindles shoot out and chromosomes are being pulled by spindles, but not yet lined in middle |
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-Forms during plant cell "cytokinesis" -How cells duplicate in plant cells, instead of cleavage furrow |
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Cell Cycle Checkpoints (and examples) |
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Requirements for cell division phases to go on. G1 --> S2. Is cell big enough? No? Stop. Is there DNA damage? If yes, stop. G2 --> M: Is DNA fully replicated? If no, stop. Is there DNA damage? If yes, stop. Metaphase to Anaphase: Are all sister chromatids attached? If no, stops. Also: from G1 ---> S/G2 ---> M, depends on activation of a protein cyclin-dependent kinase (CDK) |
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-DNA Replication begins at single site on bacteria chromosome -Replication enzymes work in opposite directions on chromosome -Daughter chromosomes separate, and Z ring forms at cell. Cell wall appears -Two identical daughter cells |
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