Term
| which statement about the biodisposition of penicillins and cephalosporins is not accurate? |
|
Definition
| renal tubular reabsorption of beta lactams is inhibited by probenecid |
|
|
Term
| the primary mechanism of antibacterial action of cephalosporins involves inhibition of |
|
Definition
| rxns involving transpeptidation |
|
|
Term
| the most appropriate tx of gonorrhea in this pat is |
|
Definition
| ceftriaxone IM as a single dose |
|
|
Term
| immunofluorescent microscopic examination of fluid expressed from the penile chancre of this pt revealed treponemes. b/c he appears to be infected w/ treponema pallidum, the best course of action would be to |
|
Definition
| inject IM benzathine penicillin G |
|
|
Term
| which statement about imipenem is accurate |
|
Definition
| in renal dysfunction, dosage reductions are necessary to avoid seizures |
|
|
Term
| an elderly debilitated pt has a fever believed to be due to an infection. he has extensive skin lesions scrapings of which reveal the presence of large numbers of gram positive cocci. the drug to use for tx of this pt is |
|
Definition
|
|
Term
| a 36 yo woman recently txed for elukemia is admitted to hospital w/ malaise, chills, and high fever. gram stain of blood reveals the presence of gram negative bacilli. the initial dx is bacteremia and parenteral antibiotics are indicated the records fo the pt reveal that she had a severe urticarial rash, hypotension and respiratory difficulty after oral penicillin V about 6 mo ago. the drug regime n for empiric tx is |
|
Definition
|
|
Term
| tx of this pt should be initiated immediately w/ IV administration of |
|
Definition
| cefotaxime plus vancomycin |
|
|
Term
| the molecular basis for the resistance of pneumococci to penicillin G is |
|
Definition
| changes in penicillin binding proteins |
|
|
Term
| if this pt had been 82 yrs old and the gram stain of the smear of CSF had revealed gram positive rods resembling diphtheroids the antibiotic regimen for empiric tx would include |
|
Definition
|
|
Term
| which statement about cefotetan is accurate |
|
Definition
| it has an antibacterial spectrum the includes B fragilis |
|
|
Term
| a pt needs antibiotic tx for native valve, culture positive infective enterococcal endocarditis. his medical hx includes a severe anaphylactic rxn to penicillin G during the past year. the best approach would be tx w/ |
|
Definition
|
|
Term
| this drug has activity against many strains of P aeruginosa. however, when it is used alone, resistance has emerged during the course of tx. the drug should not be used in penicillin-allergic pts. its activity against gram-negative rods is enhanced if it is given in combination w/ tazobactam |
|
Definition
|
|
Term
| which statement about vancomycin is accurate |
|
Definition
| it is not susceptible to penicillinase |
|
|
Term
| which statement about ampicillin is not accurate |
|
Definition
| eradicates most strains of MRSA |
|
|
Term
|
Definition
| Block cell wall synthesis by inhibiting peptidoglycan cross-linkage |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Blocks peptidoglycan synthesis |
|
|
Term
| Type of resistance found with vancomycin |
|
Definition
|
|
Term
| Penicillins active against penicillinase secreting bacteria |
|
Definition
| Methicillin, nafcillin, and dicloxacillin |
|
|
Term
| Cheap wide spectrum antibiotic DOC for otitis media |
|
Definition
|
|
Term
| Class of antibiotics that have 10% cross sensitivity with penicillins |
|
Definition
|
|
Term
| PCN active against pseudomonas |
|
Definition
| Carbenicillin, piperacillin and ticarcillin |
|
|
Term
| Antibiotic causing red-man syndrome, and prevention |
|
Definition
"Vancomycin, infusion
at a slow rate and antihistamines" |
|
|
Term
| Treatment of resistant pseudomembranous colitis |
|
Definition
|
|
Term
| Cephalosporins able to cross the BBB |
|
Definition
| Cefuroxime (2nd) generation and Ceftazidime |
|
|
Term
| Drug used for N. gonorrhea in females |
|
Definition
|
|
Term
| Cephalosporin causes kernicterus in neonates |
|
Definition
| Ceftriaxone or cefuroxime |
|
|
Term
|
Definition
|
|
Term
| cephalosporins not able to cross the BBB |
|
Definition
|
|
