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BCP 401 Lect 24
Soloman, Parkinson's
28
Pharmacology
Undergraduate 4
11/20/2017

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Term
LRRK2
Definition
Leucine-rich repeat kinase 2, contributes to Lewy bodies, autosomal dominant
Term
Park1
Definition
a-synuclein, contributes to lewy body formation. Autosomal dominant
Term
Pink1
Definition
autosomal resessive gene implicated in Parkinson's disease
Term
parkin
Definition
autosomal recessive gene
Term
DJ-1
Definition
autosomal recessive gene
Term
MPTP
Definition
a nuerotoxin discovered in 1980s, can contribute to Parkinsons by selectively inducing damage in DA neurons. This MPTP is converted to MPP+ by MAOB in CNS which is a high affinity substrate for DA reuptake transporters.
Term
paraquat, maneb
Definition
Pesticides and herbicides, can contribute to parkinsons
Term
Pathophysiology of PD
Definition
Loss of dopaminergic nuerons in the substantia nigra pars compacta
Appearance of intracellular inclusion bodies known as lewy bodies
Term
L dopa
Definition
Precursor for dopamine, about 1-3 hour half life, peak plasma concentration in half to 2 hours. Renal excretion is about 90% after an original dose in 48 hours.
Term
Carbidopa, Levidopa, Sinemt
Definition
Carbidopa prevents L dopa from being converted to DA in the bloodstreem. Inhibits peripheral DDC so more LDopa can get to the brain. Has symptoms and awkward off times
Term
Sinemet Adverse effects
Definition
Dyskenesia's still present. Behavioral changes, cardiovascular disease. Also have negative drug interactions, such as being a Dopamine receptor antagonist, MAO inhibitors antagonism. Also on/off periods.
Term
Carbidopa, Ldopa, Rytary
Definition
Carbidopa prevents L dopa from being converted to DA in the bloodstreem. Inhibits peripheral DDC so more LDopa can get to the brain. Reduces off time, better than sinemet
Term
Carbidopa, Levidopa, Entacapone
Stalevo
Definition
Entacapone is a COMT inhibitor, Carbi is a DDecarbox inhibitor, Even more LDopa get into system. Stalevo is for advanced PD
Term
Apomorphine, Apokyn
Definition
A subcutaneous injection that is a DA agonist. can be used as a rescue agent
Term
Pramipexole, mirapex
Definition
Oral, minimize off effect, can be used 2-6 times a day, affinity for d3 over d2. DA agonist
Term
Ropinirole, requip
Definition
oral, minimize on/off effect taking 2-6 times a day. preferntial for d2/d3. DA agonists
Term
Rotigotine, neupro
Definition
Transdermal system, affinity D3> d1/d2> d4/d5. Also used for restless leg syndrome. DA agonist
Term
Bromocriptine, Parlodel
Definition
DA agonist, Ergoline class, taken 3x a day, and has affinity for D2 and 5Ht.
Term
Perfolide, permax
Definition
DA agonist, Ergoline class, witdrawn 2007. 3x a day, affinity for D1 and 2, and 5Ht
Term
Trihexyphenidyl, Benztropine mesylate(coquentin)
Definition
Anticholinergic for musc receptor, restore balance between Ach and DA. Taken 2x a day. Atropine like symptoms
Term
Selegiline, Eldepryl
Definition
Oral MAO-B inhibitor, blocks breakdown of DA in striatum. Converted into an amphetamine like by product which is why side effect.
Term
Selegiline HCl, Zelapar
Definition
Oral MAO-B inhibit, taken once. Block breadown of DA in striatum
Term
Rasagaline, Azilect
Definition
MaoB blocker, oral. useful for NMS, taken once a day
Term
Tolcapone, tasmar
Definition
COMT inhibitor, taken 2-3 times a day, provide average of 1.7-2.9 on time for L dopa.
Term
Amantadine
Definition
Another type of med, increases DA release from store, keeps it in synapse. Weak antagonism of glutamate.
Term
Coenzyme Q10
Definition
Nueroprotection, electron acceptor, potent antioxidant, slow decline on motor scales
Term
Creatine
Definition
nueroprotection, promitochondria effects, may reduce accumulation of asynucli and lipid oxidation with CoQ10
Term
Vitamine C and E
Definition
Antioxidant
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