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Basic Science Physiology Month 1 Day 1 Respiratory
Basic Science Physiology Month 1 Day 1 Respiratory
57
Physiology
Graduate
05/06/2018

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Term
Conducting zone
Definition
lets air in and out of the lungs, oral and nasal cavities, trachea, bronchi, bronchioles. lined by ciliated cells that release mucus which is moved out of the respiratory organ to trap and remove particles that come in with air. contains smooth muscle to control the diameter of the bronchioles and bronchi to control how much air is getting in and out. upper parts are made of cartilage. also known as anatomic dead space bc the cells don't participate in gas exchange
Term
Respiratory zone
Definition
cells participate in gas exchange, respiratory bronchioles- transitional bronchioles with smooth muscle and some cilia and no cartilage, also consists of alveolar ducts and alveolar sacs, this is where respiration actually occurs via gas exchange
Term
receptors that control bronchioles
Definition
beta-2 receptors, control smooth muscle that constricts to let less air in or relaxes to let more in
Term
terminal bronchioles give rise to
Definition
respiratory bronchioles that form alveoli
Term
cells that line the alveoli
Definition
pneumocytes- type I and II. type II releases surfactant, necessary because the alveoli need water to function but water is bad for the lungs
Term
surfactant
Definition
a phospholipid that reduces the surface tension of water so that the water does not form droplets and cause drowning
Term
alveolar macrophages
Definition
get rid of bacteria, viruses and foreign particles then get taken up by the mucus of the conducting zone
Term
elastin
Definition
a protein that can change its shape and become longer or shorter so alveoli can expand as air comes in and recoil as air leaves
Term
alveoli pulmonary capillaries
Definition
communicate with the pulmonary vasculature that is bringing in deoxygenated blood from the right heart to drop off CO2 and pick up O2 and take it back to the heart to be pumped to the rest of the body
Term
why does CO2 diffuse out into the alveoli and oxygen go into the capiallaries
Definition
because the capillaries contain a higher level of CO2 and a lower level of oxygen
Term
lymphatic drainage
Definition
to sample the foreign material and make antibodies and T cells as needed
Term
Conducting zone
Definition
lets air in and out of the lungs, oral and nasal cavities, trachea, bronchi, bronchioles. lined by ciliated cells that release mucus which is moved out of the respiratory organ to trap and remove particles that come in with air. contains smooth muscle to control the diameter of the bronchioles and bronchi to control how much air is getting in and out. upper parts are made of cartilage. also known as anatomic dead space bc the cells don't participate in gas exchange
Term
Respiratory zone
Definition
cells participate in gas exchange, respiratory bronchioles- transitional bronchioles with smooth muscle and some cilia and no cartilage, also consists of alveolar ducts and alveolar sacs, this is where respiration actually occurs via gas exchange
Term
receptors that control bronchioles
Definition
beta-2 receptors, control smooth muscle that constricts to let less air in or relaxes to let more in
Term
terminal bronchioles give rise to
Definition
respiratory bronchioles that form alveoli
Term
cells that line the alveoli
Definition
pneumocytes- type I and II. type II releases surfactant, necessary because the alveoli need water to function but water is bad for the lungs
Term
surfactant
Definition
a phospholipid that reduces the surface tension of water so that the water does not form droplets and cause drowning
Term
alveolar macrophages
Definition
get rid of bacteria, viruses and foreign particles then get taken up by the mucus of the conducting zone
Term
elastin
Definition
a protein that can change its shape and become longer or shorter so alveoli can expand as air comes in and recoil as air leaves
Term
alveoli pulmonary capillaries
Definition
communicate with the pulmonary vasculature that is bringing in deoxygenated blood from the right heart to drop off CO2 and pick up O2 and take it back to the heart to be pumped to the rest of the body
Term
why does CO2 diffuse out into the alveoli and oxygen go into the capiallaries
Definition
because the capillaries contain a higher level of CO2 and a lower level of oxygen
Term
lymphatic drainage
Definition
to sample the foreign material and make antibodies and T cells as needed
Term
when does the fetus start to make surfactant
Definition
at 6 months
Term
ventilation
Definition
the process of moving air into and out of the lungs
Term
external respiration
Definition
the process of transporting oxygen into the blood and carbon dioxide out
Term
transport
Definition
the process of moving oxygen through the bloodstream using hemoglobin
Term
internal respiration
Definition
the unloading of oxygen to the tissues and taking up carbon dioxide
Term
atmospheric pressure
Definition
760 mm Hg
Term
how do we move air around
Definition
differences between pressures in the air and inside the respiratory system
Term
range of intrapulmonary pressure and air movement
Definition
759 to 761. when it's just below atmospheric pressure that gives a driving force for air to move into the alveoli during inspiration, when it's just above atmospheric pressure just before expiration that gives a driving force for air to move out of the alveoli and out of the lungs
Term
pressure in the intrapleural space
Definition
generally about 4 mmHg below atmospheric pressure, creating a vacuum to keep the lungs open
Term
pneumothorax
Definition
when the pressure in the intrapleural space is dissipated by an injury and the lungs collapse
Term
boyle's law
Definition
the pressure of a gas is inversely proportional to the volume in which the gas is contained
Term
what happens when the intercostals and diaphragm contract?
Definition
the thoracic cavity gets larger stretching the volume of the alveoli and reducing their pressure to below atmospheric pressure-- a driving force for air to enter the lungs. as the muscles relax the pressure in the alveoli goes up (because the volume goes down) to above atmospheric pressure leading to exhalation and driving air out of the lungs
Term
tidal volume
Definition
the volume of air that goes into and out of lungs in normal relaxed breathing, generally about a half liter
Term
graph of respirations upward is ___, downward is __
Definition
inspiration, expiration
Term
vital capacity
Definition
ask pt to breathe deeply and fully in and out during spirometry, 4.5-5 L
Term
Residual volume
Definition
the amount of air left after exhaling completely so that the alveoli don't collapse, about 1.5 L
Term
total lung capacity is generally around
Definition
6L, vital capacity plus residual volume
Term
to measure actual residual volume use
Definition
helium
Term
functional residual capacity
Definition
the difference from the bottom of a normal relaxed exhalation to the amount that could possibly be exhaled
Term
inspiratory capacity
Definition
from the bottom of the exhalation curve for normal relaxed breathing to the total amount that can be taken in, generally about 3 L
Term
inspiratory reserve
Definition
from the top of the inhalation curve for normal relaxed breathing to the total amount that can be taken in
Term
expiratory reserve
Definition
after a normal relaxed exhale to the total amount that can be exhaled (not including the residual volume)
Term
what happens during asthma
Definition
the brochioles constrict so you can't get air in and the conductive zone becomes obstructed
Term
examples of obstructive/resistance disorders
Definition
asthma, severe allergies, pneumonia, tumors that are blocking the bronchioles
Term
beta 2 adrenergic receptors can get expanded during
Definition
fight or flight, exercise
Term
beta 2 adrenergic receptors can get restricted during
Definition
allergic reaction
Term
mathematical equation of bronchoconstriction
Definition
any time you have a 2x reduction in the diameter of the bronchiole you have a 16X increase in resistance
Term
resistance disorders also called
Definition
obstructive
Term
restrictive disorders also called
Definition
compliance
Term
examples where alveoli can't change their size so they can't change their pressures
Definition
lack of surfactant, build up of mucus in the alveoli, scar tissue/fibrosis leading to resistance in inhalation, ex pneumonia (also compliance due to fluid build up), emphysema (part of COPD) (lose elasticity of alveoli- stay expanded, pushes air out, resistance to exhalation),
Term
most disorders of the lung have a combination
Definition
of compliance and obstructive impacts
Term
normally most ppl can get all their air out how fast
Definition
1 sec (at FEV1)- forced expiratory volume at 1 sec
Term
FEV1 in asthma pt
Definition
greatly reduced bc conducting zones are smaller bc diameter is reduced
Term
spirometry in someone with pneumonia
Definition
tidal volume fairly normal but when asking to take in a deep breath can't get nearly as much in or blow out as much due to obstruction from mucus and fluid buildup
Term
spirometry in emphysema
Definition
normal but much larger amount of air in lungs bc can't exhale completely, classic compliance disorder, resistance to exhalation due to loss of elastin fibers
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