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Basic Genetics
Lecture 1+2
17
Biology
Undergraduate 2
11/22/2013

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Term
menedlian genetics: classic F2 generation
BbxBb
Definition
1BB:2Bb:1Bb
Term
what is polymorphism?
Definition
Term
pleiotrophy
Definition
one locus affects two or more traits
Term
Epistasis
Definition
alleles at one locus affect the expression of alleles at a different locus.
Term
Linkage
Definition
Two or more loci are on the same chromosome.
Term
Example of pleiotrophy in cats can cause?
Definition
deafness & White pigments
Term
Melanocyes
Definition
control development of pigments and electric signals
Term
Calculate allele frequencies(A,a) by proportion P H Q (100,90,10)
Definition
A=100/200+45/200=.725
a=10/200+45/200=.275
Term
3 equations used to calculate allele frequencies used before:
Recall it them! p=? q=? ?=?
Definition
p=P+.5H
q=Q+.5H
p+q=1
Term
KK-128
Kk-70 genotype frequencies?
kk-18
Definition
128/216=.59
70/216=.33
18/216=.08
Term
What happens to p& q in random mating
Definition
They don't change q+p=1
Term
Random mating, what is P, H, Q
f(A)=p=.55
f(a)=q=.45
using equations:
pxp=
2pq=
qxq=
Definition
P=.3025
H=.495
Q=.2025
sum of All=1
Term
know the difference between number and proportions:
AA=100 Aa=75 aa=25
calculate number of alleles:
calculate proportion of alleles:
Definition
#:A=275 a=125 T=300

pro: P=.5 H=.375 Q=.125 T=1
Term
possible confusion when calculating H
Definition
use small q and p
don't use big Q and P
H= 2pq
Term
what does the Hardy-Weinberg Equilibrium principle state?
Definition
states that allele and genotype frequencies in a population will remain constant from generation to generation in the absence of other evolutionary influences (Wikipedia)
Term
What are some evolutionary influences?
Definition
Migration
mutation
and selection
Term
understanding of this statement.
Definition
“Allele frequencies and genotypic frequencies remain constant and genotypic frequencies are determined by allele frequencies”
when the H-W eqilibrium is used.
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