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Basal ganglia/cerebellum
Neuro
64
Biology
Undergraduate 4
11/30/2011

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Term
Basal ganglia function
Definition
planning, initiation, and termination of complex movements
Term
Basal ganglia components
Definition
caudate nucleus, putamen, globus pallidus, subthalamic nucleus, substancia nigra
Term
Caudate + putamen
Definition
striatum
Term
When these circuits are damaged..
Definition
patients can not switch smoothly from starting movements to stopping movements
Term
Inputs of basal ganglia
Definition
Caudate and putament
Term
Outputs from basal ganglia
Definition
substancia nigra par reticulate
internal segment of globus pallidus
Term
Glutamate
Definition
excitatory
Term
GABA
Definition
inhibitory
Term
Input target cells
Definition
medium spiny neurons of striatum
Term
The putamen receives input from..
Definition
the sensory and motor cortices - largely associated with movement
Term
The caudate receives input largely in the ..
Definition
association areas
associated with eye movement and cognitive functions
Term
The only cortical areas that do not project into the basal ganglia are the
Definition
primary visual and primary auditory cortex
Term
When the stratum is at rest ..
Definition
Globus pallidus is tonically active, thereby VA/VL complex of thalamus, so there is no excitation of upper motor neurons
Term
When the stratum is transiently excited..
Definition
globus pallidus is transiently inhibited and VA/VL complex of thalamus is dishinibited so it can excite the upper motor neurons in the cortex
Term
Example of disinhibition
Definition
saccadic eye movements
inactivation of tonically active cells of substantia nigra pars reticulate
Term
Dopamine from the SNpc stimulates the ..
Definition
direct pathway and inhibits the indirect pathway
Term
Parkinsons disease
Definition
reduction of DA on brain
damage of pathway from substancia nigra to striatum
increased output of basal ganglia to thalamus
Term
Huntingtons Disease
Definition
loss of striatal neurons
decreased output of basal ganglia to thalamus
Term
Ballism
Definition
diminished activity of sub thalamic nucleus
Term
Tardive dyskinesia
Definition
associated with hypersensitivity of DA receptors resulting in hypersensitivy to the effects of DA
Term
Parkinsons disease: indirect vs. direct
Definition
direct route excites supplementary motor area
indirect route inhibits supplementary motor area
Term
direct route
Definition
striatium to output of nuclei
Term
indirect route
Definition
through sub thalamic nucleus
Term
Ballismus cause
Definition
lesion to contralateral subthalamic nucleus; most often due to a stroke involving the small ganglionic branch of the posterior cerebral artery
Term
Cerebellum
Definition
coordinated execution of ongoing movements
Term
3 traditional roles of the cerebellum
Definition
muscle tone, balance sensorimotor coordination
Term
like the basal ganglia, the cerebellum alters the output of
Definition
UMNS
Term
The cerebellum compares:
Definition
what you thought you were going to do (according to motor cortex) with what you are actually doing (according to proprioceptive feedback of the limbs) and correct the movement if there is a problem
Term
Cerebellum also responsible for
Definition
motor learning (bike)
Term
Lesions within the cerebellum disrupt..
Definition
coordination of limb and eye movements, impair balance and decrease muscle tone
Term
Superior peduncle
Definition
efferents to red nucleus
Term
Middle peduncle
Definition
afferents from contralateral pontine nuclei
Term
inferior peduncle
Definition
afferent from spinal cord and brainstem
Term
3 gross parts of the cerebellum
Definition
paleocerebellum (anterior)
neocerebellum (lateral hem)
archicerbellem (floccolondular lobe)
Term
vestibulocerebellar inputs
Definition
vestibular fibers to flocculonodular lobe
Term
spinocerebellar inputs
Definition
anterior love via spinocerebellar tract
Term
cerebrocerebellar inputs
Definition
pons and inferior olivary nucleus of medulla to neocerebellum
Term
mossy fibers
Definition
from pontine nuclei (input from corticospinal tract that is relayed to purkinje cells)
Term
climbing fibers
Definition
from inferior olivary nucleus
Term
norepinephrine fibers
Definition
from locus ceruleus and 5HT fibers from rap he nuclei in brain stem
Term
Granule cells
Definition
send axons to molecular layer to form unmyelinated parallel fibers which project to dendritic trees of Purkinje cells and golgi cells
Term
3 deep cerebellar nuclei
Definition
emboliform nucleus
fastigal nucleus
dentate nucleus
Term
Main inputs
Definition
mossy fibers, climbing fibers
Term
Main outputs
Definition
thalamus
red nucleus
vestibular nuclei
Term
thalamus
Definition
cerebellar outputs involved in sensorimotor coordination
Term
red nucleus
Definition
cerebellar outputs involved in reflexes and muscle tone
Term
vestibular nuclei
Definition
cerebellar outputs involved in balance
Term
3 layers of cerebellum
Definition
granule layer (deep - most cells)
Purkinje cell (middle)
molecular (superficial, dendritic trees of purkinje)
Term
Climbing and mossy fiber pathways to deep nuclei are..
Definition
excitatory
Term
interneurons (golgi, basket and stellate cells) are..
Definition
inhibitory
Term
Purkinje cell input is..
Definition
inhibitory
Term
basic input-to-output operation of cerebellum is to ..
Definition
convert excitatory inputs to inhibitory
Term
balance
Definition
fastigal nucleus receives fibers from midline projects to lateral vestibular nucleus via both direct and indirect routes
Term
reflexes and muscle tone
Definition
emboliform nucleus receives input from midline cerebellar cortex and projects to red nucleus and VL thalamus
Term
sensorimotor coordination
Definition
denate nucleus receives input from lateral hemispheres of the cerebellum and projects to some red nucleus and mostly VL thalamus
Term
Ascending outputs from the cerebellum
Definition
cerebellar cortex --> deep cerebellar nuclei --> VL thalamus --> primary motor and premotor cortex
Term
Descending outputs from the cerebellum
Definition
Cerebellar cortex --> fastigial nuclei --> superior colluculs, reticular formation --> LMN of medial ventral horn
Term
functional organization of cereballar outputs
Definition
cerebellem --> superior cerebeal peduncle --> cortico and rubro tracts --> limbs
Term
Cerebellum receives input from
Definition
sensorimotor
Term
BG receives input from
Definition
entire cerebral cortex
Term
Cerebellum sends output to
Definition
premotor
Term
basal ganglia sends output too
Definition
premotor and association
Term
cerebellum has direct ties to
Definition
spinal cord and brain stem while BG does not
Term
disorders of cerebellum
Definition
hypotonia
ataxia
termors
genetic
congential
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