Term
|
Definition
Gram +
Cluster of cocci
Extracellular pathogen
Catalase + (distinguishable from strep)
Coagulase + (distinguishable from other staph)
Facultative anaerobe |
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Term
|
Definition
Surface Ag: sugar capsule: adherence to foreign objects, peptidoglycan, teichoic acid
Toxins: pore forming/dermonecrotic: alpha-hemolysis, beta-toxin, gamma-toxin, superAg, enterotoxins
Enzymes: staphylokinase: dissolves clots, penicillinase: dissolves antibiotics, DNAse, protease, lipase |
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Term
|
Definition
Evasion of immune system: leukocidins and hemolysins: kill phagos, protein A: prevents opsonization and blocks Ab, catalase: resist respiratory burst
Attatch to surface proteins, produces toxins which causes tissue damage, boils, carbuncles, impetigo, pneumonia
Toxigenic disease: scalded skin syndrome, TSS (fever, rash, hypotension), food poisoning: enterotoxin, no organism necessary |
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Term
| Staph Aureus Transmission |
|
Definition
Wounds
Aerosol
Food poisoning |
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Term
|
Definition
| Normal flora of human anterior nares and skin |
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Term
|
Definition
Vancomycin
Penecillin-resistant |
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Term
|
Definition
| High salt media (MSA), forms yellow colonies |
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|
Term
| Staph Aureus Control of Production |
|
Definition
Cell-density dependent control, wait until lots before attacking
Agr D is sensed by Agr C and transduced into Arg A and activates RNA III
RNA III regualtes several virulence factors
Repressed: enterotoxin A, nucleases, hyaluronidase
Activated: all other toxins, adhesins, and enzymes |
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Term
|
Definition
Gram +
Cocci in pairs/chains
Facultative anaerobe
Catalase -
Group A: beta-hemolytis, pyogenic, bacitractin-sensitive |
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Term
|
Definition
Surface Ag: hyaluronic acid capsule (mucoid), M protein class I and II - rheumatic fever (class I), Lipoteichoic acid, proteins F and G, M-like proteins
Toxins: streptolysin O: O2-labile (anaerobic), streptolysin S: serum-depended
EnzymesL streptokinase, hyaluronidase, C5a peptidase, DNAses |
|
|
Term
|
Definition
Direct infection: lipoteichoic acid binds fibronectin, M and F proteins bind closer for invasion, phagocytosis and opsonization are avoided, pharyngitis, tonsillitis, skin infections: impetigo, necrotizing fascitis
Toxin mediated: erythogenic toxin causes scarlet fever, TSS-like symptoms
Delayed immunologic rx: rheumatic fever (M protein I), glomerulonephritis |
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|
Term
| Strep Pyogen Transmission |
|
Definition
|
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Term
|
Definition
| Transient normal flora of human nasopharynx and skin |
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Term
|
Definition
|
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Term
| Strep Pneumoniae Apperance |
|
Definition
Gram + rod
Pyogenic
Catalase -
Facultative anaerobe
Alpha-hemolytic, bacitracin-resistant, optichin-sensitive |
|
|
Term
| Strep Pneumoniae Virulence |
|
Definition
Pneumolysin encoded on lysogenic phage
Sugar capsule
Cell wall: peptidoglycan, teichoic acid
Neuraminidase
Secretory IgA protease
H2O2 |
|
|
Term
|
Definition
Pore-forming
Supress respiratory burst, antiphagocytic
Pneumonia
Sinusitis
Otitis media
Menigitis
Bacteremia |
|
|
Term
| Strep Pneumoniae Transmission |
|
Definition
|
|
Term
| Strep Pneumoniae Reservoir |
|
Definition
|
|
Term
| Strep Pneumoniae Treat/Prev |
|
Definition
Pencilin
Erythromycin
Vaconmycin
Vaccine: Pneumovax, Prevnar |
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