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Bacterial Pneumonia
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22
Microbiology
Graduate
09/17/2009

Additional Microbiology Flashcards

 


 

Cards

Term
Streptococcus pneumoniae
Definition

 

  • Gram+ diplococci, a-hemolytic, catalase - 
  • Spread by respiratory droplets --> colonizes nasopharynx epithelium --> induces rusty sputum 
  • Capsule, IgA protease 
  • Often associated with otitis media, sinusitis, arthritis, endocarditis 
  • Treated with penicillin or cephalosporins

 

Term
Staphylococcus aureus
Definition

 

  • Gram+ cluster, catalase +, coagulase + 
  • Natural flora of skin 
  • Protein A, coagulase, hemolysin, pus forming, spreading factors (hyaluronidase, staphylokinase, lipase) 
  • Treat with penicillinase-resistant penicillins, vancomycin (if MRSA) 
  • Pts with chronic granulomatous disease susceptible

 

Term
Klebsiella pneumoniae
Definition

 

  • Gram- bacillus 
  • Right upper lobe, necrotizes tissue, forming cavities and inducing bloody "currant jelly" sputum 
  • Capsule 
  • Treat with 3rd generation cephalosporin 
  • Frequent cause of pneumonia in alcholics

 

Term
Escherichia coli
Definition

 

  • Gram - bacillus, ferments lactose 
  • Spread by aspiration or bacteremia
  •  Treat with TMP-SMX, penicillin, 3rd generation cephalosporin

 

Term
Pseudomonas aeruginosa
Definition

  • Gram - bacillus, form blue-green colonies with fruity odor
  • Environmental pathogen (soil, water) generally infecting immune compromised individuals (CF pts)
  • Multiple virulence factors, but as pneomania, primarily capsule forming and non-invasive 
  • Treat with fluoroquinolones 

Term
Haemophilus influenzae
Definition

 

  • Gram- bacillus, highly fastidious. 
  • Inhaled in aerosole, 
  • IgA protease. 
  • Treat with 3rd generation cephalosporins 

 

Term
Pseudomonas aeruginosa 
Definition

 

  • Gram – bacillus, forms blue colonies with fruity color. 
  • Found throughout environment, colonizes CF fibrosis pts. 
  • Multiple virulence factors, but as pneomania, primarily capsule forming and non-invasive 
  • Treat with fluoroquinolones 

 

Term
Legionella pneumophila
Definition

 

  • Poor gram stain, visualize with silver stain. 
  • Inhabits water, aerosolized in A/C and respiratory devises, phagocytosed but proliferates within phagosome. 
  • Often seen in elderly smokers. 
  • Treat with erythromycin

 

Term
Chlamydia pneumonia
Definition
  • Require Giemsa stain
  • Community acquired, exists in two states (elementary body and reticular body), EB swallowed by phagocyte, proliferates as RB, released as EB
  • Treat with doxycyclin
  • Infects young adults
  • Note: similar to Chlamydia psittaci, which is acquired from birds

 

Term
Coxiella burnetti
Definition

 

  • Obligate intracellular organism
  • Carried in cattle, sheep and goats, form spores which can be inhaled
  • Treated with tetracycline
  • Unlike other Rickettsial disease, does not cause rash and is not carried by arthropod

 

Term
Definition

S3 sounds

 

Mnemonic: SLOSH’-ing-in 

                          S1 - - - S2 - S3

Term
Definition

S4

 

Mnemonic: A-STIFF WALL = S4-S1 ... S2

Term
Definition
S2 split (physiologically normal if during inhalation, paradoxical if during exhalation)
Term
Definition

Late aortic stenosis

 

Late systolic murmur

Term
Definition

Mitral stenosis (diastolic murmur)

 

More common in female, associated with rheumatic disorder. Best heard at the apex with little radiation.

 

Term
Definition
Mitral regurgitation (systolic murmur)
Term
You listen to a patients chest at the left 5th intercostal space, midclavicular. You hear a harsh, holosystolic  murmur. S1 sounds are slightly diminished, with a regular beat occuring after S2. What is the most likely pathology? Which area of the heart are you listening to? What causes the diastolic sound?
Definition
  1. Mitral regurgitation- valve fails to close in systole, causing systolic regurgitation of blood from LV --> LA
  2. Apex
  3. S3 caused by volume overload on left ventricle
Term
You listen to a patients chest at the left 5th intercostal space, midclavicular. You hear a low-pitched rumble during diastolsis, preced by an opening "snap." S1 is accentuated. What is the most likely cause? Which area of the heart are you listening to?
Definition
  1. Mitral stenosis - thickening of mitral valve leaflets, preventing complete opening. Two component: middiastolsis and pressystolsis.
  2. Apex
Term
You listen to a patients chest at the 2nd-4th interspace, close to the right sternal border. You here a high pitched diastolic murmur, and ask the patient to sit leaning forwards. What is the most likely pathology? What would be an indication of severe pathology? What are some associated findings?
Definition
  1. Aortic regurgitation- leaflets of aortic valve fail to close completely during diastole, leading to back flow and volume overload on left ventricle.
  2. S3 or S4 (ventricular overload and increased resistance to ventricular filling, respectively)
  3. Increase pulse pressure, large and bounding arterial pulse, lateral and downward displacement, widened diameter
Term
You listen to the patient's right, 2nd intercostal space, noticing a systolic murmur that increases in volume, climaxing midsystole, before quieting. There's an S2 split during exhalation. You ask the patient to sit and lean forward. What is the most likely pathology? What causes the parodoxical split? What would you see if you looked at the carotid pulse?
Definition
  1. Aortic stenosis (congenital, rheumatic, degenerative)
  2. Premature closure of the aortic valve
  3. Delayed upstroke and decreased amplitude
Term
When listening to the left intercostal spaces (2nd-4th), you notice a soft pitched, midsystolic murmur. There is no ejection sounds, paradoxical splitting, or diastolic murmur. What is the most likely cause?
Definition
Turbulent blood flow, most likely generated by ventricular ejection of blood into the aorta. (Innocent murmur)
Term
Definition

Aortic regurgitation

 

Early diastolic decresendo

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