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Bacterial Pathogens
Medically Important Pathogens - Bacteria
48
Microbiology
Undergraduate 2
05/04/2010

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Term
Staphylococcus aureus
Definition
Gram + cocci
Local infections: (skin) cellulitis, impetigo, folliculitis, furuncles, carbuncles; (respiratory)pneumonia w/ cavitations
Systemic: actute endocarditis, meningitis, osteomyelitis, septic arthritis
Treatment: MSSA: penicillinase-resistant penicillin; MRSA: vancomycin
Term
Staphylococcus epidermis
Definition
Gram + cocci
Infection in indwelling medical devices
Endocartitis
Treatment: vancomycin and removal of foreign object
Term
Streptococcus agalactiae (Group B)
Definition
Gram + cocci
alpha hemolytic
neonatal meningitis (MOST common cause), neonatal pneumonia, neonatal sepsis
Strep agalactiae are part of the normal oral and vaginal flora and causes urinary and reproductive system infections in females
Treatment: penicillin G
Term
Streptococcus equisimilis (Group C)
Definition
Gram + cocci
pharyngits/strep throat
Term
Streptococcus mutans (viridans)
Definition
Gram + cocci
catalase -, alpha hemolytic, bile-esculin negative
Local: dental ( S. mutans) brain or abdominal abscesses( S. intermedius)
Systemic: Subacute Bacterial Endocarditis (SBE)
Treatment: penicillin G
Term
Streptococcus pneumoniae
Definition
Gram + cocci
catalase -, alpha hemolytic, bile-esculin negative
Local: Otitis media
Systemic: meningitis
Treatment: penicillin
MAJOR CAUSE of community acquired pneumonia
Term
Strepcococcus pyogenes (Group A strep)
Definition
Gram + cocci
Pharyngitis, Impetigo, Scarlet fever, Toxic Shock Syndrome
Treatment: penicillin G
Term
Enterococcus faecalis
Definition
Gram + cocci
Local: UTI, biliary tract infections
Systemic: Subacute Bacterial Endocarditis (SBE)
2nd most common cause of nosocomial infections UTI is US due to high resistance
biliary/hepatic surgery
VRE: vancomycin resistant enterococci
Term
Bacillus anthraxis
Definition
Gram + bacilli; Spore forming
Can cause cutaneous, pulmonary or intestinal anthrax with septicemia
Usually fatal
Treatment: penicillin
Term
Bacillus cereus
Definition
Gram + bacilli; Spore forming
Food poisoning- uncooked food or when food is re-warmed and spores germinate
4 toxins
Treatment: rehydration and prevention
Term
Clostridium botulinum
Definition
Gram + bacilli; Spore forming
Adult: food poisoning - botulism
Infant botulism: floppy baby syndrome
Treatment: antitoxin; respiratory support
Term
Closttridium difficile
Definition
Gram + bacilli; Spore forming
Nosocomial gastroenteritis
Treatment: oral vancomycin
Major cause of hospital acquired diarrhea, often transmitted by the hands of hospital personnel
Antibiotic associated
Term
Clostridium perfringens
Definition
Gram + bacilli; Spore forming
Gas gangrene and food poisoning
Surgical removal of infected areas
Penicillin for weak infections; Disease caused by toxins and extracellular enzymes produced by bacteria
Term
Clostridium tetani
Definition
Gram + bacilli; Spore forming
Tetanus, spastic paralysis, lockjaw
Treatment: clean wound; antitoxin; DTaP vaccine booster; penicillin
Term
Corynebacterium diptheria
Definition
Gram + cocci; nonsporeforming
Diptheria
Treatment: DTaP vaccine booster; antitoxin; penicillin
Acute, potentially fatal diphtheria by potent exotoxin so urgent treatment is essential
Term
Listeria monocytogenes
Definition
Gram + bacilli; nonsporeforming
Neonatal meningitis and sepsis
Immunocompromised patients
Treatment: amphicillin
Opportunistic infection ( AIDS pts)
Intracellular organism, which infects special groups, pregnant women, newborns and immunosuppressed patients
Term
Neisseria gonorrhea
Definition
Gram - cocci
Gonorrhea
Local genital tract infection
Systemic- septic arthritic
Pelvic Inflammatory Disease
Treatment: penicillin G; amoxycillin
Term
Neisseria meningitides
Definition
Gram - diplococci
Meningitis
penicillin G; rifampin for prophylaxis; vaccine
Major cause of meningitis, especially in close quarters, dorms
Neonates are protected by maternal antibodies until 6 mon.
Term
Bartonella henselae
Definition
Gram - bacilli; nonenteric
Endocarditis
Term
Bordetella pertussis
Definition
Gram - bacilli; nonenteric
Pertussis/whooping cough
Highly contagious; respiratory droplets
Vaccine: DTaP (aP stands for acellular pertussis)
Pediatric disease - 60 million people worldwide; 10,000 cases in US
Erythromycin
Term
Brucella melitensis
Definition
Gram - bacilli; nonenteric
Brucellosis; fever
Zoonotic
Treatment: pasteurize milk; gentamycin
Most commonly occurs from ingestion of contaminated animal products or direct skin contact
Term
Francisella tularensis
Definition
Gram - bacilli; nonenteric
Tularemia
Treatment: streptomycin
Live vaccine for high risk individuals
Zoonotic bacteria - primarily rabbits; also trans. by ticks, lice, mites or contact with infected animal at skin
Term
Gardnerella vaginalis
Definition
Vaginosis
Term
Haemophilus influenza B
Definition
Gram - bacilli; nonenteric
Local: Otitis, pneumonia
Systemic: meningitis, septic arthritis, cellulitis
Treatment: 3rd generation cephalosporin
Hib vaccine
Only humans carry
Aerosol
MOST COMMON CAUSE of MENINGITIS in CHILDREN; problem in close quarters
Term
Legionella pneumophila
Definition
Gram - bacilli; nonenteric
Water aerosols, nosocomial respiratory - Legionnaire's Disease
Same signs and symptoms of bacterial pneumonia
If not treated, 20% mortality
Lives like intracellular parasite
Tolerates heat, chlorination
Can live in water pipes, showers, vaporizer, spa, whirlpools, AC systems
Treatment: erythromycin
Common cause of atypical pneumonia
Term
Bacteroides spp
Definition
Gram - bacilli; enteric
Bacteremia; GI, pelvic abscesses
Treatment: drain abscess; antibiotics
Most common in GI normal flora
Term
Camplobacter jenjuni
Definition
Gram - bacilli; enteric
bloody diarrhea; secretory diarrhea
81% of poultry has Camplobacter
MOST COMMON cause of diarrhea in the world
Term
Citrobacter freundii
Definition
Gram - bacilli; enteric
Bacteremia; nosocomial and opportunistic infections
Treatment: Gentamycin
Term
E. Coli
Definition
Gram - bacilli; enteric
Traveler's diarrhea; UTI
Treatment: rehydration and penicillin
MOST COMMON CAUSE of UTI
MOST COMMON CAUSE of NEONATAL MENINGITIS
MOST COMMON CAUSE of NEONATAL PNEUMONIA
Personal hygiene important
One of the most common Nosocomial Infections
Term
Enterobacter spp
Definition
Gram - bacilli; enteric
Meningitis
Nosocomial and opportunistic infections
Wound, blood, lung and UTI infections
Treatment: Gentamycin
Sewage, water, and soil
Term
Helicobacter pylori
Definition
Gram - bacilli; enteric
gastritis; peptic ulcers
Treatment: amoxycillin
MOST COMMON CAUSE of ULCERS
Term
Klebsiella pneumoniae
Definition
Gram - baccili; enteric
Pneumonia, nosocomial UTI
Treatment: 3rd generation cephalosporin
Term
Proteus mirabilis
Definition
Gram - bacilli; enteric
Prostatitis, nosocomial UTI
Treatment: amphicillin
MOST COMMON CAUSE of UTI in NURSING HOME PATIENTS with indwelling CATHETERS
Term
Psuedomonas aeruginosa
Definition
Gram - bacilli; enteric
Prostatitis, pneumonia, nosocomial UTI, edocarditis, osteomyelitis
Treatment: penicillin
Associated with moisture and can be introduced in hospitals through water in respiratory equipment, flowers
Can cause chronic pneumonia in CF patients
Term
Salmonella typhii
Definition
Gram - bacilli; enteric
Bloody diarrhea/dystentery; typhoid fever
Term
Serratia marcescens
Definition
Gram - bacilli; enteric
Opportunistic and nosocomial infections, wound, blood, lung and UTI
Treatment: gentamycin
Term
Shigella dysenteriae
Definition
Gram - bacilli; enteric
Bloody diarrhea/dysentery
Fecal-oral transmission
Treatment: oral rehydration
Term
Vibrio cholera
Definition
Gram - bacilli; enteric
Cholera - "rice water" diarrhea; dehydration
Treatment: rehydration and tetracycline
Contaminated water
Term
Mycobacterium avium
Definition
Acid-fast rods
MAC
Term
Mycobacterium bovis
Definition
Acid-fast rods
CNS
Term
Mycobacterium leprae
Definition
Acid-fast rods
Leprosy - Hansen's Disease
Various antibiotics
Term
Mycobacterium tuberculosis
Definition
Acid-fast rods
TB
Various antibiotics
Term
Mycoplasma hominis
Definition
Wall-less cells; pleomorphic
Vaginosis
Term
Mycoplasma pneumonia
Definition
Wall-less; pleomorphic
Pneumonia and walking/atypical pneumonia
Treatment: Erythromycin; tetracycline
Most commonly affects young people, especially those in close quarters
MOST COMMON CAUSE of ATYPICAL PNEUMONIA
Term
Borrelia burgdorferi
Definition
Spriochete
Lyme disease
Treatment: tetracycline
Lyme disease is the most common vector-borne disease
Term
Treponema pallidum
Definition
Spirochete
Syphilis
Term
Chlamydia trachomatis
Definition
Obligate intracellular bacteria
Silent STD - chlamydia
Treatment: tetracycline
Most frequent cause of bacterial STD I the US; most frequent cause of blindness worldwide
Term
Ricksettsia rickettsii
Definition
Obligate intracellular bacteria
Rocky mountain spotted fever
Treatment: tetracycline
Commonly occurs along east coast due to dog tick bite
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