Term
| seasons for enterovirus and WNV |
|
Definition
| enterovirus- spring; WNV - late summer, early fall |
|
|
Term
| signs and symptoms of acute bacterial meningitis |
|
Definition
| altered mental status, headache, meningeal signs, fever, photophobia, CN palsies, nausea/vomiting |
|
|
Term
| TB/fungal meningitis: clinical, pathology |
|
Definition
| subacute, granulomatous, targets basilar meninges |
|
|
Term
| common causes of meningitis in immunocompromised pts (3) |
|
Definition
|
|
Term
| young adults bacterial meningitis |
|
Definition
|
|
Term
|
Definition
|
|
Term
| HIV is a risk factor for which meningitis? |
|
Definition
|
|
Term
| neonates bacterial meningitis (3) |
|
Definition
| GBS, Gram negatives, Listeria |
|
|
Term
| adult bacterial meningitis (2) |
|
Definition
| Strep pneumoniae, Listeria |
|
|
Term
| highest mortality rates among... |
|
Definition
| pneumococcus infections, neonates, and elderly |
|
|
Term
| path of acquisition and infection |
|
Definition
| nasopharynx -> bacteremia or meningeal invasion -> subarachnoid space |
|
|
Term
| host defenses vs. bug offenses (3) |
|
Definition
| sIgA - IgA protease; phagocytosis - capsule; cilia - pili |
|
|
Term
| complement deficiency increases risk for... |
|
Definition
|
|
Term
| splenectomy increases risk for... |
|
Definition
| H. influenza and Strep pneumoniae |
|
|
Term
| post-exposure antibiotic prophylaxis is indicated for... |
|
Definition
| household contacts, nursery contacts, N. meningitis, H. influenza |
|
|
Term
| immunizations are available for which bugs? |
|
Definition
| Hib, pneumococcus, N. meningitis |
|
|
Term
| antigenic component of S. pneumoniae and N. meningitis |
|
Definition
S. pneumonia = Gram + = teichoic acids
N. meningitis = Gram - = LPS |
|
|
Term
| how does inflammation change the BBB? |
|
Definition
|
|
Term
| pathogenesis of cytokines effect on CBF |
|
Definition
| cytokines -> all edema types + vasculites -> increase ICP + infarction -> decrease CBF |
|
|
Term
| contraindications for LP (5) |
|
Definition
| hx of CNS disease, new onset seizure, elevated ICP (papilledema), immunocompromised, focal neurologic deficit |
|
|
Term
|
Definition
| protein <50, glucose 50-60, WBC <5, clear |
|
|
Term
1. acute bacterial meningitis CSF values
2. fungal/TB meningitis
3. viral meningitis |
|
Definition
1. high protein, low glucose, high PMNs, cloudy
2. moderate changes in all values; high TC/BCs
3. normal glucose; high TC/BCs |
|
|
Term
| tx for bacterial meningitis |
|
Definition
| 3rd generation cephalosporin, vancomycin +/- ampicillin |
|
|
Term
| most common cause of aseptic meningitis |
|
Definition
|
|
Term
| clinical presentation of HSV meningitis vs. enterovirus meningitis |
|
Definition
| HSV - severe; enterovirus - benign, self limited |
|
|
Term
| ddx for non infectious aseptic meningitis |
|
Definition
| cyst/abscess, endocarditis, sarcoid, cancer, lupus |
|
|
Term
| children bacterial meningitis |
|
Definition
|
|
