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Bacteria III
Zoonotic Bacteria
90
Pathology
Kindergarten
07/19/2012

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Term
bacteria which are found in animal reserviors
Definition
zoonotic bacteria
Term
G + rod acquired through exposture to animals or animal products
Definition
B anthracis
Term
Three major syndromes: cutaneous, inhalational, and GI
Definition
B. anthracis
Term
Papule-vesicle-edema forms around and regional lymphodenopathy. Vesicle ruptures and an ulcer remains surrounded by a black eschar
Definition
Cutaneous anthrax
Term
Spores are inhaled, phagocytosed and carried to lymph nodes by phagocytes where spores germinate and release toxin. Hemorrhagic mediastinitis
Definition
Inhalational anthrax
Term
Bacteremia with Anthrax leads to...
Definition
anthrax meningitis and may lead to shock
Term
Uncommon, eating undercooked meat contaminated with this pathogen. Causing severe, bloody diarrhea, mortality greater than 50%
Definition
GI anthrax
Term
G- coccobacillus, transmitted by direct contact with skin of deer, cattle, rabbits, rodents and BITE OF A TICK OR DEER FLY
Definition
Francisella tularensis
Term
Main types of febrile illnesses (ocular-grandular, pneumonic, ulcero grandular
Definition
F. tularensis
Term
G- facultative intracellular transmitted by fleabites or aerosols.
Definition
Yersinia pestis
Term
Killed hundreds millions of people in history and tens of millions in India, china at the beginning of the twentieth century
Definition
Great Pandemics and BLack Death of Y pestis
Term
Y pestis skin inoculation causes
Definition
Lymph node enlargement-buboes
sepsis and neutrophils
Term
Y pestis inhalation
Definition
sepsis and neutrophils
Term
Bubo shows massive proliferation, exudate with tissue swelling, tissue necrosis, hemorrhage and thrombosis
Definition
Y pestis morphology
Term
3 clinical forms of Y pestis
Definition
Bubonic (skin), Septicemic (no buboes), Pneumonic (inhalation)
Term
Small G- rods infecting monocytes and macrophages in humans and mammals.
Definition
Brucellosis
Term
Brucellosis transmission
Definition
direct contact with animals
inhalation of aerosols
eating contaminated meat or milk
Term
Br. melitensis from
Definition
sheep and goats
Term
B. abortus from
Definition
cattle
Term
B suis from
Definition
swine
Term
B. canis from
Definition
dogs
Term
Generalized infection of Brucellosis involves
Definition
Reticulo-endothelial system generating hepatosplenomegaly
Term
lung, heart, GI, spondylitis, neurological, with waxing and waning fever, and fatigue
Definition
Brucellosis
Term
G + rod found in domestic animals and birds and causes food borne infections from dairy products, chicken, and hot dogs. Invade both phagocytic and non-phagocytic cells
Definition
Listeria monocytogenes
Term
Listeria in pregnant women
Definition
bacteremia crosses placenta into amnionitis and may result in abortion
Term
Listeria in neonates
Definition
neonatal sepsis with cutaneous rash
Term
Listeria in elderly and immunosuppressed
Definition
exudative meningitis
Term
Anthropod borne disease named after a connecticut town, caused by Ixodes deer ticks.
Definition
Borrelia burgdorferi-lyme disease
Term
Stage 1 of lyme disease
Definition
erythema chronicum migrans (bulls eye), fever, lymphadenopathy, neck stiffness
Term
Stage 2 of Lyme disease (early dissemination) 4-12 wks
Definition
hematogenously spread, cardiac arrhythmias, meningitis, with cranial neuritis (bell's palsy)
Term
Stage 3 of Lyme disease (late dissemination) 2-3 years
Definition
chronic arthritis and encephalitis
Term
Morphology of Lyme disease
Definition
skin and sinovial biopsy specimens show infiltration with lymphocytes, plasma cells, and histiocytes, edema, and arteritis.
Term
Insect transmitted disease produced by a spirochete, characterized by recurrent fevers during bacteremia.
Definition
Borrelia recurrentis (relapsing fever)
Term
Epidemic relapsing fever transfered by
Definition
body louse which only infects humans
Term
endemic relapsing fever is transmitted from rodents to humans through
Definition
bites of soft bodied ticks
Term
Enlarged spleen with congestion and hypercellularity, focal necrosis (neutrophils and spirochete)
Definition
Borrelia
Term
Leptospira in dogs
Definition
L. canicola
Term
Lesptospira in swine and cattle
Definition
L. pomona
Term
Leptospira affecting renal tubules of rodents
Definition
L. icterohemorrhagic
Term
Transmission of Leptospira
Definition
rats urine contaminated water, mud penetrate abraded skin
Term
High fever, jaundice, hepatitis, meningitis, acute tubular necrosis and renal failure (Leptospira)
Definition
Weil disease
Term
Obligate intracellular parasite gram neg bacteria
Definition
Chlamydia
Term
Difficult to grow in cultures
Definition
Chlamydia
Term
Sensitive to large spectrum antibiotics but not penicillin
Definition
Chlamydia
Term
Infectious form released from infected host cell enters cell via endocytosis. (form of Chlamydia)
Definition
Elementary body
Term
Form of Chlamydia which replicates within the host cell vacuoles
Definition
Reticulate body
Term
In what cell are intra-cytoplasmic inclusions of chlamydia
Definition
epithelial cells
Term
Ch. pneumonia is transmitted by
Definition
aerosols
Term
Reservoir of Ch. psittaci
Definition
avian causing atypical pneumonia
Term
Transmission of Ch. psittaci
Definition
aerosols through inhalation of dried excreta (birds); bite of a bird and direct contact with a patient
Term
Microscopy of Ch. psittaci
Definition
Intra-cytoplasmatic boies with alveolar damage, consolidation, pulmonary edema
Term
Lethality of Ch. psittaci
Definition
focal necrosis and mononuclear infiltrates in liver, spleen, kidneys, heart
Term
Diagnosis of Ch. psittaci
Definition
Rise in specific antibodies
Term
Up to 10% of all people carry the bacteria in the reproductive tract
Definition
Chlamydia urethritis and cervicitis
Term
70% of infected women have ______on the cervix
Definition
asymptomatic carriage of Chlamydia
Term
Most prevalent STD in USA
Definition
Chlamydia
Term
Infants born by infected mothers get (chlamydia)
Definition
conjunctivitis and neonatal pneumonia
Term
Chlamydia in females
Definition
cervicitis, salpingitis, PID, proctitis
Term
Chlamydia in males
Definition
prostatitis and epididymitis
Term
Has serotypes of A B and C causing follicular kerato conjunctivitis; leading global cause of blindness through scarring
Definition
Chlamydia trachomatis
Term
Transmission of Chlamydia trachomatis
Definition
Direct contact, flies, fomites
Term
Suppuration, lymphoid cell follicles, ulceration, vascular invasion, fibroblast ingrowths, eventually scarring leading to blindness
Definition
Ch. trachomatis
Term
Has serotypes L1, L2, L3 causing lymphogranuloma venereum, which is an STD (Nicolas Favre disease)
Definition
Ch. trachomatis
Term
Stage 1 of Ch. trachomatis -lymphogranuloma venereum
Definition
small ulcer, with neutrophil and granuloma at base, chlamydial inclusions in cells
Term
Stage 2 of Ch. trachomatis-lymphogranuloma venereum
Definition
Buboes, supporative with matted nodes, stellate abscesses, and fistulae discharging pus
Term
Stage 3 of Ch. trachomatis-lymphogranuloma venereum
Definition
Chronic inflammatory infiltrate, dense fibrosis, with later stages of rectal stenosis and chronic genital lymphedema
Term
Small pleomorphic rod or coccoid, obligate intracellular gram negative bacteria
Definition
Rickettsiae
Term
Vectors of Rickettsial
Definition
ticks, mites, fleas, lice
Term
Transmission of Rickettsia
Definition
Arthropod bite/ contact with aerosols from animal excreta
Term
Induced endocytosis; multiply in several cell types; do not generate any toxins but causes immune response.
Definition
Rickettsiae
Term
Immune response from Rickettsiae
Definition
Cytolytic T lymphocyte dependent; gamma ingerferon antibodies- can convey passive protection
Term
Diagnosis of Rickettsiae
Definition
skin biopsy (RMSF) and immunofluorescent staining; specific serum antibody titers, direct culture of rickettsiae. Weil Felix reaction (Typhus) for some
Term
Morphology of this bacteria is a skin rash, skin eschar= well circumscribed nodular, dark crusted lesion
Definition
Rickettsia
Term
Man-Louse-Man cycle causing epidemics with poor sanitation and over crowding
Definition
R. prowazeki
Term
Transmission is from the louse feces penetrate skin abrasions from scratching or inhalation
Definition
R. prowazeki
Term
Triad of R. prowazeki
Definition
Feaver, maculopapular rash, fever
Also: apathy, stupor, coma
Term
Typhus nodule with small vessel lesion in brain and other organs, focal infiltration of leukocytes
Definition
R. prowazeki
Term
Clinical form of typhus; reinfection typhus with rickettsiae dormant in spleen
Definition
Sporadic typhus - Brill Zinsser disease
Term
Bite of blood sucking ticks (Dermacentor); the ticks are both the vectors and the reservoir. Found in US
Definition
R. rickettsii RMSF
Term
Main clinical signs of RMSF
Definition
rash including palms and soles spreading from extremities to trunk, eshcar at bite site, 2-12 days incubation
Term
Endothelial lesions underlying the rash cause arteritis and thrombosis, generating necrosis
Definition
RMSF
Term
Tiny pleomorphic bacteria that lack a cell wall, called PPLO's; commonly causes disease of fowl and cattle
Definition
Mycoplasma (Eaton Agent)
Term
Non-gonococcal urethritis- frequent and poor diagnosed, chronic pelvic inflammatory disease
Definition
Mycoplasma urethritis
Term
Mycoplasms may produce _____which means the infection of the placenta, dreadful condition for the pregnancy and the life of the pregnant woman
Definition
chorio-amnionitis
Term
Transmission of Myco pneumo
Definition
Aerosol, droplets, (3-10%) exposed become infected; most in close living quarters
Term
Pathogenesis of M. pneumonia
Definition
disruption of cilia producing cold agglutinins and complement fixing antibodies. These antibodies may cause false positive serological tests for syphilis
Term
Microscopy of M. pneumonia
Definition
Interstitial pneumonia, alveolar air spaces empty with thickened walls, intra septal inflammation with mononuclear infiltrate
Term
Also called walking pneumonia
Definition
M. pneumonia
Term
Peri-orificial, ecto-dermitis, formed by ulcerated papule which can be bacterial super- infected. associated with M. pneumonia
Definition
Stevens Johnson syndrome
Term
Myocarditis, miringitis, transverse myelitis are complication of this bacteria
Definition
M. pneumonia
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