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Autonomics Overview
Autonomics Overview
18
Pharmacology
Post-Graduate
10/26/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
alpha-1 receptors located? what type of receptor?
Definition

on smooth muscle 

alpha-adrenergic receptor 

sympathetic effects 

Term
beta 2 located? receptor type?
Definition

smooth muscle 

adrenergic receptor 

sympathetic effects 

Term
beta 1? located? receptor type?
Definition

heart 

beta-adrenergic receptor 

sympathetic effects 

Term
All parasympathetic effects are mediated by what receptors? 
Definition
muscarinic 
Term
Acetylcholine signal termination occurs primarily by? 
Definition
NT degredation by Acetylcholinersterase 
Term
Catecholamine signal transduction termination occurs by?
Definition

NT reuptake (both pre and post synaptic receptors) 

NT diffusion 

Term
Does breakdown play a role in signal termination for acetylcholin? cholinergics? 
Definition

Signal termination is dependent on break down for acetylcholine 

signal termination is independent of breakdown for the cholinergics. 

Term
How are catecholamines broken down 
Definition

MAO plays a role in breakdown of virtually all catecholamines

dopamine is also broken down via COMT

Term

 
 
What receptor is also a monovalent cation channel
What ions move? 

Definition

Nicotinic ACh-Receptor 

The receptor interacting with ACh allows Na+ to flow in & K+ to exit the cell. 

Term

The Ga-subunit of a G-protein

 

 what receptor? 

acts on? 

effect on cAMP?

Definition

 
b1,2,3-adrenergic receptors; D1 dopamine receptor 
activates 
adenylylcyclase (AC) activity > increased cAMP

Term

The GI a-subunit of a G-protein 

 what receptor? 

acts on? 

effect on cAMP?

Definition
 a2-adrenergic receptor, D2, dopamine receptors; M2 muscarinic ACh receptor decreases AC activity> decreased  cAMP
Term

The  Gq a-subunit of a G-protein 

 what receptor? 

acts on? 

Definition

M1 & M3 muscarinic ACh receptors, a1-adrenergic
activates PLC(a ) >increased IP3+DAG  & increased free Ca++

Term
The baroreceptor reflex
Definition

 (1) Increased arterial pressure activates stretch receptors in the aortic arch and carotid sinus.

(2)  impulses to the brain stem vasomotor center (VMC).

(3)  increases vagal (parasympathetic) outflow and slows the heart.

reduces stimulation of sympathetic stimulation of the heart and blood vessels.

Term
Botulism toxin does what?
Definition
inhibits the release of ach
Term
Bretylium 
Definition
inhibit the release of sympathetic neurotransmission 
Term

Black widow spider venom (α-latrotoxin)*

Definition
increase release of Acetylcholine 
Term
Amphetamine
Definition
increase the release of sympathetic NT 
Term
cocaine
Definition
inhibit reuptake of sympathetic NT 
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