Term
alpha-1 receptors located? what type of receptor? |
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Definition
on smooth muscle
alpha-adrenergic receptor
sympathetic effects |
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Term
beta 2 located? receptor type? |
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Definition
smooth muscle
adrenergic receptor
sympathetic effects |
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Term
beta 1? located? receptor type? |
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Definition
heart
beta-adrenergic receptor
sympathetic effects |
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Term
All parasympathetic effects are mediated by what receptors? |
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Definition
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Term
Acetylcholine signal termination occurs primarily by? |
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Definition
NT degredation by Acetylcholinersterase |
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Term
Catecholamine signal transduction termination occurs by? |
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Definition
NT reuptake (both pre and post synaptic receptors)
NT diffusion |
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Term
Does breakdown play a role in signal termination for acetylcholin? cholinergics? |
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Definition
Signal termination is dependent on break down for acetylcholine
signal termination is independent of breakdown for the cholinergics. |
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Term
How are catecholamines broken down |
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Definition
MAO plays a role in breakdown of virtually all catecholamines
dopamine is also broken down via COMT |
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Term
What receptor is also a monovalent cation channel.
What ions move?
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Definition
Nicotinic ACh-Receptor
The receptor interacting with ACh allows Na+ to flow in & K+ to exit the cell. |
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Term
The Gs a-subunit of a G-protein
what receptor?
acts on?
effect on cAMP?
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Definition
b1,2,3-adrenergic receptors; D1 dopamine receptor
activates
adenylylcyclase (AC) activity > increased cAMP
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Term
The GI a-subunit of a G-protein
what receptor?
acts on?
effect on cAMP?
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Definition
a2-adrenergic receptor, D2, dopamine receptors; M2 muscarinic ACh receptor decreases AC activity> decreased cAMP |
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Term
The Gq a-subunit of a G-protein
what receptor?
acts on? |
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Definition
M1 & M3 muscarinic ACh receptors, a1-adrenergic
activates PLC(a ) >increased IP3+DAG & increased free Ca++
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Term
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Definition
(1) Increased arterial pressure activates stretch receptors in the aortic arch and carotid sinus.
(2) impulses to the brain stem vasomotor center (VMC).
(3) increases vagal (parasympathetic) outflow and slows the heart.
reduces stimulation of sympathetic stimulation of the heart and blood vessels. |
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Term
Botulism toxin does what? |
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Definition
inhibits the release of ach |
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Term
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Definition
inhibit the release of sympathetic neurotransmission |
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Term
Black widow spider venom (α-latrotoxin)*
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Definition
increase release of Acetylcholine |
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Term
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Definition
increase the release of sympathetic NT |
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Term
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Definition
inhibit reuptake of sympathetic NT |
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