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Autonomic system
usmle
16
Health Care
Graduate
05/06/2009

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Cards

Term
Gq receptors
Definition
(hey Qutie) HAV1 M&M: H1, alpha1, V1, M1, M3; Gq stimulates PLC which converts lipids to PIP2 which is converted into IP3 (releases intracellular Ca) and DAG (stimulates PKC)
Term
Gi receptors
Definition
MAD 2's: M2, alpha2, D2; Gi inhibits adenylyl cyclase, which decreases cAMP and PKA
Term
Gs receptors
Definition
Better Be Division 1 (plus H2 V2); B1, B2, D1, H2, V2; Gs stimulates conversion of ATP to cAMP which increases PKA
Term
Muscarinic actions thru G proteins
Definition
M2= heart; inhibitory action so works thru Gi
M1 (CNS and enteric) and M3 (glands, bladder, gut, ciliary) make you Queasy, work thru Gq
Term
Sensory fibers: C, A delta
Definition
pain and temp (smallest diameter); all skin, epidermis, some viscera; C is slower pain (unmyelinated)
Term
Meissner's corpuscles
Definition
hairless skin; fine touch, adapt quickly (onset/offset)
Term
Pacinian corpuscles
Definition
deep skin, ligaments, joints; Pa and Vibration; rapidly adapting so detects onset/offset
Term
Merkel's disks
Definition
cup-shaped, encapsulated; hair follicles; static touch (shapes, edges, textures), adapt slowly
Term
Sensory nerves ascend thru here ipsilaterallly after synapsing in DRG
Definition
Dorsal columns
Term
Vesamicol
Definition
inhibits assembly of ACh into NT vesicles in presynaptic terminal
Term
Hemicholinium
Definition
prevents reuptake of choline (none to make ACh)
Term
Metyrosine
Definition
inhibits conversion of Tyrosine to DOPA (DOPA goes to DA)
Term
Reserpine
Definition
inhibits NT vesicle assembly for NE
Term
Guanethidine
Definition
inhibits NE release
Term
NE release modulated by
Definition
NE itself (feedback inhibition via alpha 2 recs), M2 (inhibitory for heart), ACh (?), AngII (stim), amphetamines (stim)
Term
TCAs affect NE by
Definition
inhibiting reuptake (like cocaine)
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