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Autonomic Nervous System (Cholinergic Antagonists)
Unit III
7
Pharmacology
Undergraduate 2
10/28/2013

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Term
ATROPINE (**)
Definition
ANTIMUSCARINIC DRUG
-block Ach receptors competively and prevent Ach from binding to them
Actions:
mydriasis,cyclopegia
antispasmodic (reduces GI activity)
reduces bladder + intestinal motility
antidote for cholinergic agonists
antisecretor (pre-op)

SIDE EFFECTS- blurred vision, tachycardia, urinary retention, constipation
Term
SCOPOLAMINE (**)
Definition
ANTIMUSCARINIC AGENT
-motion sickness
-more effect on CNS
-must be taken before onset of motion sickness
Term
IPRATROIUM & TIOTROPIUM (**)
Definition
ANTIMUSCARINIC AGENT
-inhaled bronchodialators
-for bronchospasms in COPD
Term
Tropicamide & Cyclopentolate
Definition
ANTIMUSCARINIC AGENT
- opthalmic solutions for mydriasis & cycloplegia
Term
BENZTROPINE & TRYHEXYPHENDIYL
Definition
ANTIMUSCARINIC AGENTS
- treatment of parkinson's disease
Term
CURARE & TUBOCURARE (**)
Definition
NONDEPOLARIZING NEUROMUSCULAR BLOCKER
- binds to nicotinic receptors instead of AcH
-can produce respiratory paralysis & cardiac depression
- Antidote=Neostigmine & Pyridostigmine
Term
SUCCINYLCHOLINE (**)
Definition
DEPOLARIZING NEUROMUSCULAR BLOCKER
- binds to Ach receptor and remains attached and continuously stimulates neuroreceptor, until the receptor becomes unresponsive to stimulus, so flaccid paralaysis occurs
-electroconvulsive therapy, endotracheal intubation
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