• Results from depressed T cell function, which causes over production of antibody by B cell
• Pt makes anit-nuclear antibodies
• Most important complex is Anti DNA complex

1. Women = 20-40 w/ hereditary tendencies
2. Butterfly rash over nose, see better with UV light
3. Involves joint - renal failure cause of death

1. L.E cells
2. Anti DNA antibody - 1959
3. Complement activation = decrease C3
4. + Fluorescent screen = profile for individual antibodies
5. FANA - Indirect. Has high sensitivity and low specificity

1. Anti - ds DNA
2. Anti - ss DNa
3. Anti - Histone
4. Antibodies to ENA - Sm & RNP
5. Anti -RNA nucleolar

• Most specific
• Diagnostic w/ low C3
• Homogenous or peripheral staining

• Lupus & other diseases
• not detected in fluorescent panels

• Homogenous pattern
• found in active, severe, or drug nduced lupus

• 7-25% of ppl w/ lupus
• Speckled pattern

• RNA & histone
• Speckled pattern
• Lupus, MCTD

1. anti - ss - A/Ro
2. Anti - ss - B/La

Found in Scleroderma & Sjogren's Disease

• Can cause False + screening for syphilis
• Lupus anticoagulant = ^ PT & PTT

• Women = 30-50 - joint deformaties
• 4-6 weeks = arthritis, joint nodules, + RF test, joint swelling, xrays showing joint erosions

• Your find - IgM antibody to the Fc of IgG - in;

Lupus, scleroderma, and other B cell diseases

1. Agglutination test - + in 75% w/ RA
2. ESR - ^
3. CRP - ^