Term
Which of the following drugs would not be a good choice for a cat?
a. chlorambucil
b. prednisolone
c. azathioprine
d. cyclosporine
e. leflunomide |
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Definition
| c. azathioprine--can cause fatal neutropenia in cats |
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Term
| Which drug(s) cause(s) signs of iatrogenic hyperadrenocorticism? What are the clinical signs of this disease? |
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Definition
Prednisone, Prednisolone
Clinical signs: PU/PD, polyphagia, weight gain, CNS signs, behavioral/secondary changes, pancreatitis, GI ulcers, steroid hepatopathy, panting, secondary infections |
|
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Term
| What is the glucocorticoid of choice in cats? |
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Definition
|
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Term
| What is the immunosuppressive dose of GC? |
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Definition
|
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Term
| What is the mechanism of action for azathioprine? |
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Definition
|
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Term
| Which drug has side effects that include: myelosuppression, gastroenteritis, pancreatitis, and neuromuscular blockade? |
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Definition
|
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Term
| What is the mechanism of action for chlorambucil? |
|
Definition
Alkylating agent
Cytotoxic |
|
|
Term
Which of the following is more suitable for use in a cat?
a. Azathioprine
b. Chlorambucil |
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Definition
|
|
Term
| What are some side effects of chlorambucil administration? |
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Definition
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Term
Which of the following drugs works as a pyrimidine synthesis inhibitor, causing inhibition of cytokines involved in cellular differentiation and signal transduction?
a. Chlorambucil
b. Leflunomide
c. Prednisolone
d. Pentoxyfylline |
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Definition
|
|
Term
| Gold salts can be used in autoimmune skin diseases. What is their mechanism of action? |
|
Definition
Inhibit chemotaxis
Inhibit phagocytosis
Inhibit complement activation
Inhibit antibody formation |
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Term
| Which drug(s) can cause cutaneous drug eruptions, eosinophilia, or thrombocytopenia as a side effect of administration? |
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Definition
| Gold salts--aurothiomalate, auranofin |
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Term
| Which two drugs work by inhibiting cell-mediated immunity through inhibition of IL2 production and subsequent inhibition of sensitized CTLs, and decreased antibody formation to T-cell dependent antigens? |
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Definition
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Term
| ______________ is 10 times more potent than cyclosporine, requiring owners to wear gloves before topical application to their pet. |
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Definition
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Term
| _________ works synergistically with niacinamide. |
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Definition
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Term
| What is the mechanism of action of tetracycline + niacinamide? |
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Definition
Niacinamide: inhibits IgE dependent histamine release, prevents mast cell degranulation, decreases protease release from leukocytes
Tetracycline: inhibits chemotaxis of leukocytes |
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Term
Which of the following drugs works by inhibiting TNF-alpha, inhibiting lymphocyte activation, and decreasing neutrophil degranulation? It also improves RBC deformity.
a. pentoxyfylline
b. aurothiomalate
c. tacrolimus
d. leflunomide |
|
Definition
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|
Term
| Which drug has side effects that include: gastroenteritis, gingival hyperplasia, nephrotoxicosis, papillomatosis, and hepatotoxicosis? |
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Definition
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