Term
|
Definition
|
|
Term
| Microscopic polyangiitis (MPA) |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
anti-Ro (SS-A): associated with neonatal lupus and fetal heart block
[mother's Ab is carried across the placenta to cause either fetal heart block by damaging fetal heart tissue or causing rash and cytopenia in newborn; goes away once mom's antibodies leave baby's system (months)]
anti-La (SS-B) |
|
|
Term
Limited systemic Scleroderma
lcSSc |
|
Definition
|
|
Term
| Diffuse systemic scleroderma |
|
Definition
| Anti-topoisomerase (Anti Scl-70) |
|
|
Term
Primary Raynaud's
Secondary Raynaud's |
|
Definition
|
|
Term
|
Definition
| ANA, dsDNA (causes nephritis), anti-Sm, anti-phopholipid, anti-ribosomal P (lupus psychosis0 |
|
|
Term
|
Definition
|
|
Term
|
Definition
| ANA, Anti-cytoplasmic, Anti-synthetase (associated with pulm interstitial fibrosis) |
|
|
Term
| Dermatomyositis with shawl sign |
|
Definition
|
|
Term
Acute onset, rapidly progressive myositis
poor response to tx |
|
Definition
|
|
Term
|
Definition
|
|
Term
Lupus
+
Scleroderma
+
Myositis |
|
Definition
|
|
Term
| Neonatal lupus and heart block |
|
Definition
|
|
Term
|
Definition
RF
85% sensitive, but not specific; can be + for Sjogren’s (75%), Hep C (50%) and in normal pts (5%)
Anti-CCP
[cyclic citrullinated peptides] (60% sensitive, 95% specific to RA)
o Anti-CCP may play a pathogenic role in RA
o Citrullinated proteins (fibrinogen) are present in the cytoplasm of cells in rheumatoid pannus, and also in the interstitial areas
§ are thought to provide persistence antigenic stimulation that drives the immune response in RA
HLA-DRB1 |
|
|
Term
|
Definition
|
|
Term
|
Definition
RF+
[2-10% of JIA; teens, increased HLA-DR4, resembles adult RA; rare remission & poor fxnl outcome]
RF-
[10-30% JIA; symmetric small jt dz; better fxnl] |
|
|
Term
|
Definition
(+) ANA
two types:
persistent and extended |
|
|
