Term
| This anti-psych causes agranulocytosis |
|
Definition
|
|
Term
| clinical use of clozapine |
|
Definition
| manic depressive disorder not responsive to lithium |
|
|
Term
|
Definition
No severe extrapyramidal nor hyperprolactinemia
D4 receptor
does NOT affect GABA synthesis
blocks Serotonin |
|
|
Term
| Side effects of clozapine |
|
Definition
orthastatic hypotension
GI disturbances
excessive salivation at night
FATAL AGRANULOCYTOSIS |
|
|
Term
|
Definition
bone marrow dz
leukopenia
carbamazepine |
|
|
Term
| Multiple receptor anti psychs |
|
Definition
| risperidone, olanzapine, quetiapine, ziprasidone |
|
|
Term
| mech of action of multiple receptor antipcyhs |
|
Definition
| D2 and Serotonin receptors |
|
|
Term
| this is increased by 50% when taken w/a meal |
|
Definition
|
|
Term
| half lifes of multiple receptors longest to shortest |
|
Definition
| olanzapine, ziprasidone and quetiapine |
|
|
Term
| side effects of risperidone |
|
Definition
asthenia
hyperprolactinemia
**sexual dysfunction** |
|
|
Term
| side effect of olanzapine |
|
Definition
somnolence, constipation, akathisia
**sexual dysfunction**
extrapyramidal symptoms |
|
|
Term
|
Definition
increase in QT interval
increase in aminotransferase
tardive dyskinesis |
|
|
Term
|
Definition
least amt of weight gain
prolonged QT interval |
|
|
Term
| mechanism of aripiprazole |
|
Definition
partial D2 and 5-HT agonism
partial antag on 5-HT b rec |
|
|
Term
| metabolism of aripiprazole |
|
Definition
|
|
Term
| adverse effects of aripiprazole |
|
Definition
No extra-pyramidal
No prolactinemia, lipidemia, or weight gain |
|
|
Term
| clinical use if aripiprazole |
|
Definition
| schizo w/o extra-pyramidals |
|
|
Term
| compared to first generation, which has higher extra pyrmidal and weight gain |
|
Definition
first- higher extra pyramidal
second- higher weight gain |
|
|
Term
| clinical use of Lithium carbonate |
|
Definition
bipolar depression
acute manic attacks
manic depressive |
|
|
Term
| mech of action for Li Carbonate |
|
Definition
competes with Mg binding
decrease IP3 and DAG |
|
|
Term
| adverse effects of Li carbonate |
|
Definition
decreased thyroid function
polydipsia and polyuria
cognitive blunting
**do NOT breastfeed** |
|
|
Term
| drug interactions w/Li carbonate |
|
Definition
thiazide diuretics- increased reabsorp ot Li
NSAIDs decrease elimination of LI |
|
|
Term
| use Li in caution with who |
|
Definition
| pregnancy and low Na diet |
|
|
Term
| this is given when patients do not respond to Li |
|
Definition
|
|
Term
| advantage of Valproic acid over Li |
|
Definition
|
|
