Term
| Atropine Sulfate - trade name |
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Definition
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Term
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Definition
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Term
| Atropine Sulfate - description |
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Definition
- potent parasympatholytic - inhibits actions of aCh @ postganglionic parasympathetic (primarily muscarinic) receptors
- small doses inhibit salivary and bronchial secretions
- moderate doses increase heart rate and dilate pupils
- large doses decrease GI motility, inhibit gastric acid secretion, and may block nicotinic receptor site at the autonomic ganglia and at the neuromuscular jxn
- blocked vagal effects --> increased HR, enhanced AV conduction, little / no inotropic effect
- emergency - primarily used to increase HR in life threatening, symptomatic bradycardia and to antagonize excess muscarinic receptor stimulation caused by organophosphate insecticides and chmical nerve agents (sarin, soman)
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Term
| Atropine Sulfate - Onset and duration |
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Definition
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Term
| Atropine Sulfate - indications |
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Definition
- hemodynamically significant bradycardia
- asystole
- pulseless electrical activity w/ absolute bradycardia
- organophosphate or nerve gas poisoning
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Term
| Atropine sulfate - contraindications |
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Definition
- tachycardia
- hypersensitivity
- obstructive disease of GI tract
- obstructive uropathy
- unstable cardiovasc. status in acute hemmorhage w/ myocardial ischemia
- narrow angle glaucoma
- thyrotoxicosis
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Term
| Atropine Sulfate - adverse reactions |
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Definition
- tachycardia
- paradoxical bradycardia when pushed too slow or too little dose
- palpitations
- dysrhythmias
- headache
- dizziness
- anticholinergic effects
- N+V
- flushed, hot dry skin
- allergic rxns
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Term
| Atropine sulfate - Drug interactions |
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Definition
- anticholinergic agents - may increase vagal blockade
- digitalis, cholinergics, neostigmine - potential adverse effects
- antihistamines, antidepressants, antipsych, procainamide, quinidin, thiazides - may enhance atropines effects
- amantadine - increased toxicity
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Term
| Atropine sulfate - Supply |
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Definition
| 1 mg / 10 ml prefilled syringe |
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Term
Atropine Sulfate - Dosage and Admin
Adult bradydysrhythmias |
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Definition
0.5 mg every 3-5 min for response (max 3 mg)
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Term
Atropine sulfate - D+A
ped bradydysrhythmias |
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Definition
0.02 mg/kg IV/IO/ET
min does 0.1 mg, max 0.5 child, 1mg adolescent
may rpt in 5 min max total dose 1 mg child, 2 mg adolescent |
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Term
Atropine sulfate - D+A
adult asystole / pulseless electrical activity |
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Definition
| 1 mg IV/ ET, may rpt 3-5 min max total 0.03-0.04 mg/kg |
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Term
Atropine sulfate - D+A
adult - anticholinesterase poisoning |
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Definition
| 1-2 mg IV push every 5-15 min until effects observed, then every 1-4 hr for 24 hr |
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Term
Atropine sulfate - D+A
ped - anticholinesterase poisoning |
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Definition
| 0.02 - 0.05 mg/kg/dose , usual 1-5 mg IV, may rpt 10-20 min until observe, then 1-4 hr for 24 hr |
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Term
| atropine sulfate - special considerations |
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Definition
preg c
causes pupil dilation |
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