Term
| How does thelophylline work? |
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Definition
Blocks phosphodiesterase causing increase in cyclic AMP (cAMP) which promotes release of epinephrine from adrenal cells. This results in bronchodilation, diuresis, CNS and cardiact stimulation |
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Term
Theophylline is a good drug for asthma but it has many side effects. What are some signs of toxicity? |
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Definition
Persistent and repetitive vomiting, ventricular tachycardias, seizures |
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Term
| IV aminophyline contains what % of theophyline? |
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Definition
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Term
| What is unique about theophylline pharmacokinetics? |
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Definition
Has first order kinetics, followed by Michaelis - Menton (or saturable) kinetics (similar to phenytoin and voriconazole). A smalla increase in dose can result in a large increase in the theophylline concentration
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Term
| What drugs can increase or decrease theophylline? |
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Definition
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