Term
| satus epilepticus is _ min or more of -2 |
|
Definition
5
continuous seizure activity
recurrent without returning to baseline |
|
|
Term
|
Definition
lasts 1-2 min
self limitng
rapid return to baseline |
|
|
Term
| SE is NOT just a prolonged seizure** |
|
Definition
|
|
Term
|
Definition
GABA (decrease)
Glutamte (NMDA recpt) |
|
|
Term
after _ minutes SE becomes self sustaining?
how? -2 |
|
Definition
30
GABA recpt to BDZs decreases; increased NMDA recpt |
|
|
Term
|
Definition
tonic-clonic movements
mental impair
neurolog deficit |
|
|
Term
|
Definition
seizure activity on EEG
no typical clinical
may be mental altered |
|
|
Term
|
Definition
| pts who dont respond to normal treatment (benzo + AED) |
|
|
Term
| which SE type has highest mortality? |
|
Definition
|
|
Term
| drugs that can cause SE-3 |
|
Definition
|
|
Term
|
Definition
CNS infeciton
tumor
hypo Na/Mg, glyceimc |
|
|
Term
what is the preferred BDZ?
why?
second choice?
what is the rectal agent? |
|
Definition
lorazepam IV
longer duration
IM midazolam
diazepam |
|
|
Term
| When pateints fail secodn AED they are refracotry* |
|
Definition
|
|
Term
for refractory SE what is an option wiht current med-1
what guides therapy? |
|
Definition
give addtional bolus of med
EEG |
|
|
Term
| cont IV meds for refractory SE-3 |
|
Definition
propofol
midazolam
pentobarbital |
|
|
Term
|
Definition
infusion syndrome
hypotension |
|
|
Term
|
Definition
|
|
Term
|
Definition
| more effiacy but higher complications (time on vent etc) |
|
|
Term
| other options for refractory SE |
|
Definition
|
|
Term
| why do you give thiamine nad dextrose in seizures? whihc do you give firsT? |
|
Definition
bc thiamine is for glucose uptake in brain
give thiamine first bc if thiamine def giving dextrose wont work |
|
|
Term
which agent works faster fosphenytoin or phenyotin
whihc one would dr hasse use? |
|
Definition
neither, both same rate bc produg has to be deesterfied
fosphenytoin, as if give too much not as big of safety issue |
|
|
Term
| what is max infusion rate for phenytoin |
|
Definition
|
|
Term
| where is fosphenytoin located? |
|
Definition
|
|
Term
what is loading dose for fospheny/phenytoin?
what is teh cap?
when do you use ABW? |
|
Definition
|
|
Term
| what do you monitor and what is target for phenyotin? |
|
Definition
post-load levels (not steady state)
22-24 mcg/mL |
|
|
Term
|
Definition
1 stdy shows VPA with less ADEs
2nd study shows more effiacy, no diff ADEs
= VPA |
|
|
Term
| what meds should be avoided in seizure pts |
|
Definition
baclofen
NMBAs
imipenem
antispychotics
bupropion
meperidine
metronidazole |
|
|
Term
| where is the intraosseus diazepam admin? |
|
Definition
|
|
Term
| what are symtpoms of PRIS (propofol related insufison syndrome)-3 |
|
Definition
metabolic acidosis
arrythmia
hyperK |
|
|
Term
|
Definition
rapid admin
few side effects
no resp depression |
|
|
Term
|
Definition
|
|
Term
| problems from going from IV to eneteral phenytoin-2 |
|
Definition
converting short acting to extedned
admin with eneteral feeds is challenging |
|
|
