Term
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Definition
Bind CD52, T cell lysis, stem cell transplant prep |
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Term
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Definition
Tx: cisplatin nephrotoxicity |
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Term
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Definition
VEGF block, anti-angiogenesis |
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Term
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Definition
G2, Fe-complex -> free radicals, Sx: pulmonary fibrosis |
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Term
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Definition
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Term
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Definition
Tx: brain tumors (also Lomustine:CCNU) SE: Hepatic veno-occlusive disease |
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Term
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Definition
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Term
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Definition
Alkylate N7 of G, Intrastrand break, Sx: nephro/ototoxic |
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Term
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Definition
prodrug purine analog, antimetabolite activated deoxycytidine kinase |
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Term
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Definition
methylate at O6 of G, resistance via AGT enzyme |
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Term
Dactinomycin: Actinomycin-D |
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Definition
intercalates DNA (nonspecific), child tumors |
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Term
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Definition
glucocorticoid, Sx: osteoporosis, Cushingoid |
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Term
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Definition
decr cardiotoxicity of “-rubicin” anthracyclines |
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Term
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Definition
Topo2+Intercalates+Radicals, Sx: cardiotoxic, red urine |
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Term
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Definition
stabilize Topo2, natural podophyllotoxin |
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Term
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Definition
pyrimidine-analog, folic acid complex inhibits dTMP; SE: Hand-Foot disease, increased toxicity w/ Leucovorin |
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Term
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Definition
SERD w/ no endometrial cancer like tamoxifen |
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Term
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Definition
“nib” so tyrosine kinase inhibitor, HER1 so synergy w/ Cetuximab |
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Term
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Definition
pyrimidine antimetabolite, inhibit DNA-poly and RNR |
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Term
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Definition
free radical scavenger, inhibits RNR (ribonucleoside reductase) |
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Term
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Definition
like cyclophosphamide, Sx: CNS toxic |
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Term
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Definition
tyrosine kinase inhibitor for BCR/abl (Philly chromo) & c-kit (GIST) |
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Term
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Definition
stabilize Topo1, Sx: Gilberts (gluc-trans) Pts -> jaundice, leukopenia |
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Term
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Definition
protein synthesis inhibitor, Sx: pancreatitis, hypersensitivity |
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Term
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Definition
reduced folate, given after methotrexate, toxic w/ 5-FU |
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Term
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Definition
GnRH agonist -> oversecrete/deplete LH/FSH, decr bone/muscle |
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Term
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Definition
purine antimetabolite HGPRT-activated; Avoid allopurinol, TPMT polymorphisms |
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Term
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Definition
alkylator, activated by reducing, Sx: hemolytic anemia |
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Term
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Definition
block depolymerization of microtubules, M phase; Sx: stocking glove neuropathy |
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Term
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Definition
methylate O6-G, Sx: disulfiram-like, AGT resistance |
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Term
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Definition
tyrosine kinase inhibitor, Sx: hand-foot syndrome |
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Term
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Definition
tyrosine kinase inhibitor, Sx: graying hair, skin discolored |
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Term
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Definition
Estrogen agonist on bone / antagonist on breast; Sx: endometrial cancer |
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Term
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Definition
interstrand alkylator, Sx: cystitis, Tx: bladder cancer |
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Term
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Definition
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Term
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Definition
block polymerization of microtubules, M-phase; Sx: cumulative neurotoxic, no leukopenia |
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