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Asmt 8 Drugs - Anti-Neoplasia & Immunosuppresants
One Sentence. Main Points
36
Pharmacology
Professional
11/02/2011

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Term
Alemtuzumab
Definition
Bind CD52, T cell lysis, stem cell transplant prep
Term
Amifostine
Definition
Tx: cisplatin nephrotoxicity
Term
Bevacizumab
Definition
VEGF block, anti-angiogenesis
Term
Bleomycin
Definition
G2, Fe-complex -> free radicals, Sx: pulmonary fibrosis
Term
Bortezomib
Definition
proteasome inhibition
Term
Carmustine: BCNU
Definition
Tx: brain tumors (also Lomustine:CCNU) SE: Hepatic veno-occlusive disease
Term
Cetuximab
Definition
Ab binds EGFR-1 (HER-1)
Term
Cisplatin
Definition
Alkylate N7 of G, Intrastrand break, Sx: nephro/ototoxic
Term
Cladribine
Definition
prodrug purine analog, antimetabolite activated deoxycytidine kinase
Term
Dacarbazine: DTIC
Definition
methylate at O6 of G, resistance via AGT enzyme
Term
Dactinomycin: Actinomycin-D
Definition
intercalates DNA (nonspecific), child tumors
Term
Dexamethasone
Definition
glucocorticoid, Sx: osteoporosis, Cushingoid
Term
Dexroxazone
Definition
decr cardiotoxicity of “-rubicin” anthracyclines
Term
Doxorubicin
Definition
Topo2+Intercalates+Radicals, Sx: cardiotoxic, red urine
Term
Etoposide: VP-16
Definition
stabilize Topo2, natural podophyllotoxin
Term
Fluorouracil: 5-FU
Definition
pyrimidine-analog, folic acid complex inhibits dTMP; SE: Hand-Foot disease, increased toxicity w/ Leucovorin
Term
Fulvestrant
Definition
SERD w/ no endometrial cancer like tamoxifen
Term
Gefitinib
Definition
“nib” so tyrosine kinase inhibitor, HER1 so synergy w/ Cetuximab
Term
Gemcitabine
Definition
pyrimidine antimetabolite, inhibit DNA-poly and RNR
Term
Hydroxyurea
Definition
free radical scavenger, inhibits RNR (ribonucleoside reductase)
Term
Ifosfamide
Definition
like cyclophosphamide, Sx: CNS toxic
Term
Imatinib
Definition
tyrosine kinase inhibitor for BCR/abl (Philly chromo) & c-kit (GIST)
Term
Irinotecan
Definition
stabilize Topo1, Sx: Gilberts (gluc-trans) Pts -> jaundice, leukopenia
Term
L-Asparaginase
Definition
protein synthesis inhibitor, Sx: pancreatitis, hypersensitivity
Term
Leucovorin
Definition
reduced folate, given after methotrexate, toxic w/ 5-FU
Term
Leuprolide
Definition
GnRH agonist -> oversecrete/deplete LH/FSH, decr bone/muscle
Term
Mercaptopurine: 6-MP
Definition
purine antimetabolite HGPRT-activated; Avoid allopurinol, TPMT polymorphisms
Term
Mitomycin C
Definition
alkylator, activated by reducing, Sx: hemolytic anemia
Term
Paclitaxel
Definition
block depolymerization of microtubules, M phase; Sx: stocking glove neuropathy
Term
Procarbazine
Definition
methylate O6-G, Sx: disulfiram-like, AGT resistance
Term
Sorafenib
Definition
tyrosine kinase inhibitor, Sx: hand-foot syndrome
Term
Sunitinib
Definition
tyrosine kinase inhibitor, Sx: graying hair, skin discolored
Term
Tamoxifen
Definition
Estrogen agonist on bone / antagonist on breast; Sx: endometrial cancer
Term
Thiotepa
Definition
interstrand alkylator, Sx: cystitis, Tx: bladder cancer
Term
Topotecan
Definition
stabilize Topo1
Term
Vincristine
Definition
block polymerization of microtubules, M-phase; Sx: cumulative neurotoxic, no leukopenia
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