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Ashton West
Molecular & Cellular Radiation Biology
50
Biology
Undergraduate 3
05/26/2020

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Term
Meiosis
Definition
Genetic cells undergo process of reduction division. Reduces number of chromosomes in the parent cell
Term
Mitosis
Definition
A parent cell (somatic) divides to form 2 daughter cells identical to the parent cell. Nucleus divides first followed by cytoplasm
Term
4 Sub-phases of Mitosis
Definition
Prophase
Metaphase
Anaphase
Telophase
Term
Law of Bergoine & Tribondeau
Definition
Most radiation effects occur in cells with the least maturity and rapidly dividing cells are more sensitive to ionizing radiation
Term
Radiosensitive Cells
Radioinsensitive Cells
Definition
Skin, Lymphocytes, Erythrocytes, Intestinal Crypt, Reproductive
Brain, Muscle, Nerve
Term
Human Genome Project
Definition
Mapped the entire sequence of DNA base pairs on all 46 chromosomes. More than 1800 disease genes have been discovered
Term
Golgi Body
Definition
Aid in cell sorting, packaging, and shipping cell materials
Term
Centrioles
Definition
Only found in animal cells and helps in cell division
Term
Lyosome
Definition
Contains digestive enzymes to help break down waste products in the cell
Term
Cytoplasmic Organelles
Definition
Tubules, Vesicles, Granules, Fibrils
Term
Endoplasmic Reticulum
Definition
Transports food & molecules from one part of the cell to another
Term
Linear Energy Transfer (LET)
Definition
Wt: Tissue waiting factor
Diagnostic X-Ray LET=3keV/um
Helps to measure the potential tissue & organ damage from exposure
Term
Relative Biologic Effectiveness (RBE)
Definition
Ratio of the doses required by 2 radiations to cause the same level of effect
Diagnostic X-Ray RBE=1
Term
Oxygen Enhancement Ratio (OER)
Definition
Measure used tot obtain amount of cellular injury for a species of ionizing radiation
Term
Cell Survival Curve
Definition
Displays the radio sensitivity of a particular type of cell. This helps to determine types of cancer cells that will respond to radiation therapy
Term
Target Theory
Definition
A cell will die if target molecules ar inactivated as a result of radiation exposure
Term
Dose Response Curve
Definition
Determines radiation dose to the whole body by extrapolating the dose-response relationship from high doses
Linear non-threshold relationship
Term
Five Biological Factors that Affect Radiosensitivity
Definition
Oxygen Effect
Age
Recovery
Chemical Agents
Hormesis
Term
Stochastic
Definition
Predictable response to radiation
Term
Non-Stochastic
Definition
Random response to radiation
Term
Apoptosis
Definition
Non mitotic or non division form of cell death that occurs when cells die without attempting division during interphase
Term
Mitotic Death
Definition
Cell dies after one or more divisions
Term
Instant Death
Definition
Large number of cells die when volume is exposed to doses of 1000 Gy in a period of seconds or minutes
Term
Reproductive Death
Definition
Exposure of cells to doses of ionizing radiation form 1-10 Gy
Term
Mitotic Delay
Definition
Failure of cell to start dividing on time. Can occur when exposed to 0.01 Gy of ionizing radiation
Term
Meiosis
Definition
Genetic cells undergo process of reduction division. Reduces number of chromosomes in the parent cell
Term
Mitosis
Definition
A parent cell (somatic) divides to form 2 daughter cells identical to the parent cell. Nucleus divides first followed by cytoplasm
Term
4 Sub-phases of Mitosis
Definition
Prophase
Metaphase
Anaphase
Telophase
Term
Law of Bergoine & Tribondeau
Definition
Most radiation effects occur in cells with the least maturity and rapidly dividing cells are more sensitive to ionizing radiation
Term
Radiosensitive Cells
Radioinsensitive Cells
Definition
Skin, Lymphocytes, Erythrocytes, Intestinal Crypt, Reproductive
Brain, Muscle, Nerve
Term
Human Genome Project
Definition
Mapped the entire sequence of DNA base pairs on all 46 chromosomes. More than 1800 disease genes have been discovered
Term
Golgi Body
Definition
Aid in cell sorting, packaging, and shipping cell materials
Term
Centrioles
Definition
Only found in animal cells and helps in cell division
Term
Lyosome
Definition
Contains digestive enzymes to help break down waste products in the cell
Term
Cytoplasmic Organelles
Definition
Tubules, Vesicles, Granules, Fibrils
Term
Endoplasmic Reticulum
Definition
Transports food & molecules from one part of the cell to another
Term
Linear Energy Transfer (LET)
Definition
Wt: Tissue waiting factor
Diagnostic X-Ray LET=3keV/um
Helps to measure the potential tissue & organ damage from exposure
Term
Relative Biologic Effectiveness (RBE)
Definition
Ratio of the doses required by 2 radiations to cause the same level of effect
Diagnostic X-Ray RBE=1
Term
Oxygen Enhancement Ratio (OER)
Definition
Measure used tot obtain amount of cellular injury for a species of ionizing radiation
Term
Cell Survival Curve
Definition
Displays the radio sensitivity of a particular type of cell. This helps to determine types of cancer cells that will respond to radiation therapy
Term
Target Theory
Definition
A cell will die if target molecules ar inactivated as a result of radiation exposure
Term
Dose Response Curve
Definition
Determines radiation dose to the whole body by extrapolating the dose-response relationship from high doses
Linear non-threshold relationship
Term
Five Biological Factors that Affect Radiosensitivity
Definition
Oxygen Effect
Age
Recovery
Chemical Agents
Hormesis
Term
Stochastic
Definition
Predictable response to radiation
Term
Non-Stochastic
Definition
Random response to radiation
Term
Apoptosis
Definition
Non mitotic or non division form of cell death that occurs when cells die without attempting division during interphase
Term
Mitotic Death
Definition
Cell dies after one or more divisions
Term
Instant Death
Definition
Large number of cells die when volume is exposed to doses of 1000 Gy in a period of seconds or minutes
Term
Reproductive Death
Definition
Exposure of cells to doses of ionizing radiation form 1-10 Gy
Term
Mitotic Delay
Definition
Failure of cell to start dividing on time. Can occur when exposed to 0.01 Gy of ionizing radiation
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