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g/dl = gram per deciliter |
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Types of monosaccharides, and what they are composed of: |
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Definition
glucose and fructose (4-8 carbon atoms and a aldehyde or ketone group) |
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Oligiosaccharides are composed of: |
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Definition
(2 to 6 molecules of simple sugars linked together) |
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Disaccharides are composed of: |
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Glucose-->Pyruvate<-->lactate |
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Glucose--->pyruvate--->CO2 + H20+ ATP |
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Pentose Phosphate Pathway/ Hexose Monphosphate Shunt |
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Definition
Glucose--->ribose + CO2 + NADPH |
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Glucose--->Glucuronic Acid |
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Noncarbohydrate sources--->glucose |
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What are the other hormones that increase blood glucose levels? |
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Definition
Epinephrine, human growth hormone (hGH), cortisol, adrenocorticotropic hormone (ACTH), and thyroxine |
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Define Glycated hemoglobin: |
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Definition
The Ketoamine structure where glucose is irreversibly bound to hemoglobin. |
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Define Glycosylated Hemoglobin: |
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Definition
The reversible stage where glucose may equilibrate (attach and detach) with the hemoglin molecule. |
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[LDL-C]=[TC]-[HDL-C]-([TG]/5) |
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Hydrophobic (nonpolar), organic molecules-insoluble in water, but readily soluble in organic solvents. |
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Definition
Complexes of lipids and proteins, act as vehicles for transporting lipids in the aqueous milieu of the circulatory system |
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What are Fatty Acids, and what do they do? |
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Definition
carboxylic acids of straight-chain hydrocarbons. They provide energy through β-oxidation. |
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What makes a Saturated Fat? |
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Definition
all single bonds between carbons |
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What makes a Monounsaturated Fat |
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Definition
One double bond in a chain |
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What makes a Polyunsaturated fat? |
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Definition
more than one double bond in the chain |
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What is an essential fatty acid? |
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Definition
a Linoleic or Linolenic acid which is two polyunsaturated fatty acids, that must come from dietary sources. |
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What is the most prevelant fat in the diet? |
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Definition
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Definition
saturated fatty acids, and solid at room temp |
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Definition
unsaturated fatty acids, liquid even upon refridgeration |
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Term
Cholestrol is the precursor for: |
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Definition
steroid hormones, vitamin D, and bile acids. |
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Where is Cholestrol synthesized |
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Definition
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Where are phospholipids synthesized |
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Definition
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What are the Fat Soluble Vitamins |
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Definition
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Definition
transport lipids and facilitate the metabolism of lipids in the circulatory system |
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Term
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Definition
Lowest density lipoprotein, and mostly exogenous triglycerides from diet |
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Definition
transports triglycerides synthesized in the liver |
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Definition
the major component of LDL |
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Term
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Definition
high protein content with phospholipids and cholesterol as the major lipid components |
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What are Apolipoproteins? |
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Definition
Participate in lipoprotein metabolism as enzyme activators, enzyme inhibitors, or binding sites for cellular receptors |
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Definition
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a variant of LDL in which a molecule of the protein apo(a) is bound to apo B-199 |
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Term
Albumin: LP name and Predominant Lipid |
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Definition
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Alpha-1 (HDL): LP name and predominant lipid |
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Definition
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Alpha-2 (VLDL): LP name and Predominant Lipid |
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Definition
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Alpha-2/Beta Bridge (IDL): LP name and Predominat Lipid |
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Definition
Floating Beta, Cholesterol and Trigycerides |
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Term
Beta: LP name and predominant lipid |
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Definition
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Gamma: LP name, and predominant lipid |
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Definition
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Specimen Requirements for Lipid Testing: |
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Definition
1. Patient Fasting 2. Heparin plasma for Trigyceride assays 3.Disodium EDTA for Lipoprotein Electrophoresis 4. Serum OK if fresh, unhemolyzed, and immediately sperated from cells. Keep cold, and don't freeze. 5. mix well |
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What happens to lipids after Heart attack? |
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Definition
all blood lipid leveles decrease |
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what happens to lipids during Heparin therapy? |
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Definition
falsely decreased triglyceride levels |
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Term
what happens to lipids with alchohol ingestion or abuse? |
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Definition
Increase blood FFA level, increase VLDL production, increase blood Triglyceride level, and increase HDL |
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What happens to lipids with birth control or pregnancy? |
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Definition
decrease in cholesterol (LDL) and FFA, and increase in Triglycerides |
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What happens to lipids with steroids, beta blockers? |
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Definition
increase in serum trigylcerides (VLDL) |
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What happens to lipids in a bacteria-contaminated specimen? |
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Definition
Smudging of the pattern, plus the Beta and Pre-Beta LPs migrate fater than normal towards the anode |
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Term
Hypo-Beta Lipoproteinemia |
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Definition
low serum cholesterol because of low LDL, cuase by underproduction of Apo-B. |
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Definition
no LDL= low cholesterol levels |
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Term
Hypo-Alpha-Lipoproteinemia |
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Definition
underproduction of Apo-A, very low HDL levels, possible other lipids high |
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Term
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Definition
no HDL, due to inability to produce Apo-A |
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Term
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Definition
lack of Lipoprotein Lipase, so CM can't be cleared from blood. Hi levels of CHOL and TG. Creamy layer of CM at the top. |
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Definition
caused by increase in LDL. Blood CHOL high, but TG normal. Serum is clear. |
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Term
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Definition
increase in LDL and VLDL. High CHOL and TG. Specium is faintly turbid due to the TG |
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Definition
Floating Beta Band due to production of an abnormal lipoprotein (IDL). High CHOL and TG. Slighly turbid, and may or may not have CM present |
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Definition
most common, high TG, turbid serum |
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Term
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Definition
High TG and CHOL, turbid, with a creamy layer of CM at the top |
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Term
Fasting Blood Glucouse (FBS)
[Reference Range] |
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Definition
Serum: 70-110 mg/dL
CSF: 40-70 mg/DL
(or 2/3 of blood level) |
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Hbg A1-C
[Reference Range] |
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Definition
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OGTT (adult, 75 g load)
[Reference Range] |
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Definition
Fasting: 70-110 mg/dL
1/2 Hour: Less than 170 mg/dL
1 Hour: Less than 170 mg/dL
2 Hr: Under 110 mg/dL
3 Hr: Fasting level
4, 5 Hr: Fasting level |
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Serum Osmolality
[Reference Range]
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Definition
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Urine, 24- Hour Osmality
[Reference Range]
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Definition
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Term
Urine/Serum Osmolality Ratio
[Refence Range] |
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Definition
Random 1.0-3.0
Should be greater than 3.0 after 12 hours fluid restriction |
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Term
Adult Billirubin Values
[refence ranges] |
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Definition
Total: 0.2-1.0 mg/dL
Direct: 0.0-0.4 mg/dL |
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Term
Neonatal Bilirubin Values-
(Total=Indirect Bilirubin)
[Refence range] |
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Definition
Cord Blood: less than 4.5 mg/dL
3 Day: Less than 7.0 mg/dL
5 Day: Less than 12.0 mg/dL
7 Day: Less than 7.0 mg/dL |
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Term
Sodium
(mEq/L=mMol/L)
[Reference Range] |
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Definition
Adult Plasma: 136-146 mMol/L |
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Term
Potassium
(mEq/L=mMol/L)
[Reference Range] |
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Definition
Adult: 3.5-5.1 mMol/L
Newborn: 3.7-5.9 mMol/L |
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Term
Chloride
[Reference range] |
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Definition
Plasma: 98-106 mMol/L
Sweat: up to 35 mMol/L |
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Term
Total CO2
[reference range] |
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Definition
Venous: 23-30 mMol/L
Arterial: 22-29 mMol/L
Capillary: 22-20 mMol/L |
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Term
Bicarbonate
[reference range]
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Definition
Venous: 22-20 mMol/L
Arterial: 21-28 mMol/L
Capillary: 21-28 mMol/L |
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Term
Plasma Lactic Acid (lactate)
[reference range]
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Definition
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Blood pH
[reference range] |
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Definition
Venous: 7.32-7.42
Arterial: 7.35-7.45
Capillary: 7.35-7.45 |
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Term
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Definition
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Serum Calcium
[reference range] |
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Definition
Children values slightly higher than adults
Total: 8.4-10.2 mg/dL
2.1-2.6 mMol/L
Ionized: 1.10-1.35 mMol/L
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Term
Serum Inorganic Phosphorous
[reference range] |
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Definition
Adults: 3.0-4.5 mg/dL
Children: 4.5-6.5 mg/dL
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Term
Serum Magnesium
[reference range] |
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Definition
1.6-2.3 mg/dL
0.65-1.05 mMol/L |
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Term
Serum Iron
[reference range] |
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Definition
Males: 50-170 ug/dL
Females: 30-160 ug/dL |
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Term
Serum TIBC
[reference range] |
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Definition
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Term
Transferrin Iron Saturation
[reference range] |
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Definition
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Term
Plasma Ammonia Nitrogen
[reference range] |
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Definition
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Term
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Definition
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Definition
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Serum/Plasma Creatinine
[reference range] |
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Definition
Males: 0.6-1.2 mg/dL
Females: 0.5-1.1 mg/dL |
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Term
24-Hour Urine Creatinine
[reference range] |
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Definition
Males: 800-1800 mg/Day
Females: 600-1600 mg/day |
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Term
Creatinine Clearance (GFR)
[reference range] |
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Definition
Males: 97-137 mL/min
Females: 88-128 mL/min |
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Term
Uric Acid
(serum/plasma)
[reference range] |
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Definition
Males: 3.5-7.2 mg/dL
Females: 2.6-6.0 mg/dL
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Term
Haptoglobin
[reference range] |
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Definition
40-180 mg/dL
(as Hgb. binding capacity) |
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Term
Total Protein
[reference range]
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Definition
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Term
Albumin
[reference range] |
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Definition
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Term
A/G Ratio
[reference range] |
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Definition
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Term
CSF Protein
[reference range] |
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Definition
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Term
Urine Protein
[reference range] |
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Definition
50-150 mg/day
or
< 10 mg/dL random |
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Term
Total Cholestrol
[reference range] |
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Definition
Optimal: <200 mg/dL
Borderline: 200-239 mg/dL
High Risk: > 240 mg/dL |
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Term
LDL- Cholestrol
[reference range] |
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Definition
Optimal: <100 mg/dL
Above Optimal: 100-129
Borderline: 130-159
High Risk: 160-189
Very High: >190 mg/dL |
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Term
HDL-Cholestrol
[reference range] |
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Definition
Optimal: >40 mg/dL
High Risk: <40 mg/dL |
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Term
Triglycerides
[reference range] |
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Definition
Optimal: <150 mg/dL
Borderline: 150-199
High Risk: 200-499
Verh High: 500 mg/dL and above
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Term
Total/HDL Cholestrol Ratio
[reference range] |
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Definition
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Term
LDL/HDL Cholestrol Ratio
[reference range] |
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Definition
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Term
Amniotic Fluid L/S Ratio
(extremely dependent on method)
[reference range] |
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Definition
Mature: >2.0 with PG+
Borderline: 1.6-2.0 with PG-
Immature: <1.5 with PG- |
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Term
Total T4
[reference range]
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Definition
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Term
Total T3
[reference range] |
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Definition
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Term
T3-Uptake
[reference range] |
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Definition
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Term
TBG Saturation
[reference range] |
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Definition
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Term
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Definition
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Term
FTI
(31% method)
[reference range] |
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Definition
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Term
Serum or Plasma Glucose
(kids and adults)
[Critical Value] |
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Definition
Below 40 mg/dL= Brain damage
Above 450 mg/Dl= Diabetic Coma |
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Term
Plasma Glucose
(newborn infant-6 weeks)
[Critical Value] |
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Definition
Below 30 mg/dL= brain damage
Above 300 mg/dL= diabetic coma |
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Term
Serum Total Bilirubin
(newborn-6 months of age)
[Critical Value] |
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Definition
Above 20.0 mg/dL
May Require an Emergency Exchange Transfusion
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Term
Potassium
(children and adults- serum or plasma)
[Critical Value] |
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Definition
Below 3.0 mMol/L= Tetany, cardiac fibrillation
Above 6.1 mMol/L= arrhythmias, cardiac failure (evaluate for hemolysis) |
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Term
Potassium
(newborn- serum or plasma)
[Critical Value] |
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Definition
Below 3.0 mMol/L= Tetany, Cardiac Fibrillation
Above 6.6 mMol/L= Arrythmias, cardiac failure (check for hemolysis) |
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Term
Sodium
(serum or plasma)
[Critical Value] |
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Definition
Below 120 mMol/L= Vascular collapse, heart failure
Above 170 mMol/L= Severe hypertension, stroke, heart failure |
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Term
Serum Bicarbonate (or Total CO2)
[Critical Value] |
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Definition
Below 10 mMol/L= Severe Metabolic ACIDosis
Above 55 mMol/L= Severe Metabolic ALKALosis
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Term
Blood pH
[Critical Value] |
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Definition
Below pH 7.20= Severe ACIDosis
Above 7.6= Severe ALKALosis |
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Term
Serum or Plasma Calcium
(Total)
[Critical Value] |
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Definition
Below 6.0 mg/dL= Tetany, convulsions (check for wrong anticoagulants)
Above 13.0 mg/dL= Coma |
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Term
Serum, Plasma, or Whole Blood Calcium (Ionized)
[Critical Value] |
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Definition
Below 0.79 mMol/L= Tetany, convulsions (check for wrong anticoagulants)
Above 1.57 mMol/L= Coma |
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Term
Serum or Plasma Inorganic Phosphorous
[Critical Value] |
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Definition
Below 1.0 mg/dL= Acidosis, seizures |
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Term
Serum or Plasma Magnesium
[Critical Value] |
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Definition
Below 1.0 mg/dL= Tetany, convulsions (check for wrong anticoagulants)
Above 9.0 mg/dL= Coma (evaluate for hemolysis)
Note: Contamination from powdered gloves (talk is Mg++ and/or Ca++ Stearate) will cause drastic elevations in Calcium and/or Magnesium) |
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Term
Serum or Plasma Lithium
[Critical Value] |
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Definition
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