Term
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Definition
-> Heavy dose over a short exposure 25-110fiber/ml/yr
example jobs: miners & millers , textile workers, insulators.
--> lower exposure the longer it takes to develop. |
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Term
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Definition
Uptake in type 1 cell
- macrophage accumulation
- cascade of events: cytotoxic release by macrophages --> recruitment of fibroblasts & proliferation
Aveolitis --> progression of fibrosis and |
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Term
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Definition
1st decade of exposure
Pleural Effusion without sxs or reoccurance
Exudative : increase protein and increase mononuclear lymphocytes |
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Term
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Definition
Amphiboles persist in lung tissue more than crysotile
Amphibole 1/2 half life in terms of decades
Chrysotile 1/2 life in terms of months |
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Term
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Definition
Marker of exposure
if calcified = 20 yrs
Asymptomatic |
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Term
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Definition
X-ray may be normal --> Ct scan helps demonstrate structural pathology for biopsy.
BAL with Biopsy
AFB with pleural plaques |
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Term
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Definition
Honeycombing
Pleural change and Pleural Plaques
Heavy exposure: involvement of parenchyma and pleura. Linear interstitial changes. |
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Term
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Definition
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Term
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Definition
Increase the risk of cancer with increase exposure
Increase risk cancer with thin <0.5 , long, >10 um fibers |
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Term
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Definition
associated with Amosite, crocidolit, and actinolite
Malignant tumor of viscera which takes decades of low lvl to develop. Interlobular
Associated with Pleural Plaques
Death by restriction of vital structures. |
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Term
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Definition
Small marker for exposure
Asbestos bodies in BAL do not correlate w TFB = total fiber burden
pleural = low exposure
prenchymal = high exposure |
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Term
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Definition
Serpintine
- chysotile (white = least dangerous)
Amphobiles (ass with mesothleioma)
crocidolite (blue) , amosite |
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Term
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Definition
| Glomerulonephritis , nephrotic syndrome, end stage uremia, fabrys disease |
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Term
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Definition
remove employee from setting
lung transplant
monoclonal antibodies
tatradine, xinix , lavage |
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Term
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Definition
occurs after >20 yrs of exposure
- Hyaline nodules (round opacities) in upper lungs and hilar adenopathy due to fibrosis
- Normal pulm functioning
- Increased risk of TB |
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Term
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Definition
>1 cm nodules with calcified hylar nodes. (egg shell calcifications0
- may have symptoms of core pulmonale and decreased PFT's |
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Term
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Definition
1-3 years to develop with lipoprotenosis
respiratory failure
>90% |
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Term
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Definition
-10-15 yrs
-More diffuse fibrosis
-Smaller fibrotic nodules <80% |
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