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Arthritis
MS Module
52
Medical
Graduate
05/10/2009

Additional Medical Flashcards

 


 

Cards

Term
What is the most common joint disease?
Definition
osteoarthritis
Term
What is the most common type of osteoarthritis?
Definition
primary
Term
What is the common age of primary and secondary osteoarthritis?
Definition

primary increases incidence with age

secondary can occur in younger individuals

Term
What is eburnation and in what disease does it occur in?
Definition

It is the polishing of bone

occurs in osteoarthritis

Term
Which form of osteoarthritis has an initiating cause?
Definition
secondary
Term
What joints in the fingers and feet is osteoarthritis common in?
Definition
DIP
Term
Where are women mostly effected in osteoarthritis?
Definition
fingers and feet DIP
Term
What type of osteophyte nodes occur in the proximal digit?
Definition
Bouchard
Term
What type of osteophyte node occurs in the distal digit?
Definition
Heberdens
Term
Which osteophyte node is most common in osteoarthritis?
Definition
Heberdens
Term
What is a subchondral bone cyst?
Definition
in osteoarthritis when the bone is worn away and synovial fluid enters into the bone
Term
What are joint mice?
Definition
floating pieces of cartilage
Term

What is Charcot's joint? (3)

 

What type of osteoarthritis is it seen in?

Definition

a neuropathic joint with lack of sensation, destruction, and exaggerated osteophytes

 

secondary

Term
What type of disease is Rheumatoid arthritis?
Definition
Autoimmune inflammatory systemic disease
Term
What is the target of Rheumatoid Arthritis?
Definition
synovial membrane
Term
What is the RF composed of?
Definition
IgM anti IgG
Term
What does RA cause?
Definition
synovitis
Term
IN Rheumatoid arthritis what forms when the synovial membrane grow into the articular cartilage of the joint?
Definition
a pannus
Term
Where can a pannas spread and if it does what can it cause?
Definition
can spread to ligments surrounding joint and lead to subluxation
Term
Is there a genetic predispostion to RA?
Definition
yes
Term
What dramatic irreversible process can occur to joints in RA?
Definition
bony ankylosis
Term
WHat are the most common joints effected in RA?
Definition
PIP and MCP
Term
What can be found on the skin or in the organs of a patient with RA?
Definition
RA nodules
Term
What are the five types of arthritis studied in this module?
Definition

Osteoarthritis

Rheumatoid Arthritis

Seronegative Spondyloarthritis

Crystal induced arthritis

Infectous arthritis

Term
What type of cartilage is the target in seronegative spondyloarthropathy?
Definition
fibrocartilage
Term
What artritic disease target hyaline cartilage?
Definition

Osteoarthritis

RA

Crystal induced

Infectous arthritis

Term
Which artritis disease attacks the enthesis?
Definition
Seronegative Spondyloarthropathy
Term
WHat is the HLA most common in seronegative spongyloarthropathy?
Definition
HLA B27 +
Term
What are the two most common spondylitis?
Definition

alkylosing spondylitis

reiter syndrome

Term
What is the target bone in alkylosing spondylitis? (2)
Definition

spine

sacroiliac joint

Term
What sex and age is alkylosing spongylitis and reiters syndrome found in?
Definition
young males
Term
What is the classic triad of Reiter Syndrome?
Definition

1. Urethritis

2. Conjuntivitis

3. Arthritis

Term
What is the characteristic spine found in alkalosing spongylitis?
Definition
bamboo spine
Term
What type of infections (2) does Reiters syndrome usually follow?
Definition

GI

UTI

Term
What type of digits are characteristic of Reiters Syndrome?
Definition
sausage digits
Term
What type of inflammatory cells target the crystals in crystal induced arthritis?
Definition
neutrophils
Term
Which type of crystal has strong negative birefringence?
Definition
uric acid stones (gout)
Term
What type of crystals have weak positive birefrigence?
Definition
calcium pyrophosphate dihydrate (psuedogout)
Term
What is the shape of the uric acid crystal and the calcium pyrophosphate dihydrate crystal?
Definition

needle for uric acid

stubby for calcium pyrophosphate dihydrate

Term
What causes the destruction of the joints in the crystal induced arthritis?
Definition
neutrophil lysosomal enzymes
Term
Which type of crystal induced arthritis is most common in the big toe?
Definition
gout (uric acid)
Term
What is primary gout due to ?
Definition
metabolic defect of uric acid
Term
What is secondary gout due to?
Definition
hyperuricemia due to increased production of uric acid or Chronic renal failure
Term
What is the term used for calcium pyrophosphate dihydrate within the cartilage?
Definition
chondrocalcinosis
Term
What are the five common infections that cause infectous arthritis?
Definition

1. Strep

2. Staph

3. Hemophilus

4. Gonococcal

Salmonella

Term
How many joints are usually effected in infectous arthritis?
Definition
monoarthrosis (one)
Term
WHat is the most common joint affected by infectous arthritis?
Definition
knee
Term
What disease are sausage digits seen in?
Definition

Reiters syndrome

a seronegative spongyloarthrosis

Term
Can osteoarthritis have inflammation?
Definition
yes in erosive osteoarthritis in the most severly effected joints
Term
What happens to pain in osteoarthritis upon exercising?
Definition
gets worse
Term
What is a more specific lab test for Rheumatoid arthritis?
Definition
anti -CCP (cylic citrullinated peptid)
Term
What is the best treatment for RA, but what do you need to be careful about when administering it?
Definition

Enbrel (anti TNF-alpha)

 

watch for TB or other infections that would flare up with treatment

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