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AP Biology
From DNA to Protein
27
Biology
12th Grade
05/03/2011

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Term
transcription
Definition
the two strands of DNA double helix are unwound in a gene region; exposed bases (adenine, cytosine, guanine, and thymine) of one strand become the template for assembling a single strand of RNA; only on type of RNA (messenger RNA) transcript encodes the message that gets translated
Term
translation
Definition
amino acids are bounded together into a polypeptide chain in a sequence specified by base triplets in messenger RNA; Transfer RNA delivers amino acids one at a time to ribosomes an RNA component of ribosomes catalyzes the chain-building reaction
Term
messenger RNA (mRNA)
Definition
a single strand of ribonucleictides transcribed from DNA; the only type of RNA that carries protein-building information to ribosomes
Term
ribosomal RNA (rRNA)
Definition
a class of RNA that becomes complexed with proteins to form ribosomes; some catalyze assemble of polypeptide chains
Term
transfer RNA (tRNA)
Definition
on of a class of small RNA molecules that delivers amino acids to a ribosome; its anticodon pairs with an mRNA codon during translation
Term
uracil
Definition
one of the four nitrogen-containing bases in nucleotide monomers of RNA; also applies to a nucleotide with a uracil base component; like thymine, uracil can base-pair with adenine
Term
RNA polymerase
Definition
enzyme that adds ribonucleotides one at a time to the end of a growing strand of RNA
Term
promoter
Definition
a "start signal"; a base sequence in DNA to which RNA polymerases bind and prepare for transcription
Term
exons
Definition
protein-coding base sequences that are interrupted by noncoding sequences
Term
introns
Definition
noncoding sequences
Term
alternative splicing
Definition
the event by which the same gene can specify two or more slightly different proteins, all exons in a pre-mRNA transcript of the gene are retained or some are removed and the rest spiced in various combinations for the mature transcript; one gene can specify two or more proteins that differ slightly in form and function
Term
genetic code
Definition
the set of 64 different codons
Term
codons
Definition
base triplets in mRNA
Term
anticodon
Definition
a ribonucleotide base triplet that can base-pair with a complementary codon in an mRNA transcript; used with tRNA binding to mRNA
Term
"wobble effect"
Definition
freedom in codon-anticodon paring at a base where a third base can join in a codon
Term
UAC codon
Definition
the only kind of tRNA that can start the initiation stage of translation; it is the complementary to the START codon of every mRNA transcript
Term
elongation stage of translation
Definition
2nd stage of translation; a polypeptide chain is synthesized while the mRNA passes between the two ribosomal subunits
Term
termination
Definition
last stage of translation; the mRNA's STOP codon enters the ribosome which causes the polypeptide chain and the mRNA to detach from the ribosome
Term
gene mutation
Definition
changes in the nucleotide sequence of a DNA molecule; can alter the message that becomes encoded in mRNA
Term
base-pair substitution
Definition
the wrong nucleotide may become paired with an exposed base on the DNA template and slip by proofreading and repair enzymes, so when it is translated, it may call for the wrong amino acid or a premature STOP codon
Term
insertion
Definition
one or more base pairs become inserted into DNA; frameshift mutation
Term
deletions
Definition
one or more base pairs are deleted from DNA; frameshift mutation
Term
frameshift mutation
Definition
shifts the "three-bases-at-a-time" reading frame, ultimately altering the protein
Term
transposons
Definition
transposable element; a stretch of DNA that jumps spontaneously and randomly to a different location in the genome and may mutate a gene
Term
ionizing radiation
Definition
form of radiation with enough energy to eject electrons from atoms
Term
nonionizing ratiation
Definition
form of radiation that carries enough energy to boost electrons to higher energy levels but not enough to eject them from an atom
Term
alkylating agents
Definition
of a molecule, replacement of a hydrogen atom by a hydrocarbon group
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