Anti-Herpes Antiviral

-Guanine nucleoside analogue

-activated by Thymidine Kinase and inhibs DNApol

*Can ^ risk of nephrotoxicity

w/ AZT can cause lethargy

Anti-Herpes antiviral (CMV)

-guanosine analogue, inhibits DNA pol (activited by Thymidine Kinase)

-More toxic than acyclovir and is a potential mutagen and carcinogen

Anti-herpes antiviral

-cytosine nucleoside analogue

whereas acyclovir only works in infected cells, Cidofovir can become activated in unifected cells BUT has greater affinity for CMV viral DNA pol.

Anti-herpes antiviral

-non-nucleoside inhibitor (no activation w/ TK)

Tx: CMV retinitis or 2nd line CMV

*Hypocalcemia, nephrotoxicity

Anti-herpes antiviral

-used for CMV iritis

Anti-sense RNA

Anti-influenza antiviral

-Blocks uncoating of Influenza A (targets M2 proton channel)

Anti-influenza antiviral

-Blocks viral release (can't leave to infect other cells)

-Neuraminidase inhibitor

-Works on Flu A and B (sialic acide analogue)

*can cause behavioral problems

Wide spectrum Antiviral agent

HCV, RSV

-inhibits IMPDH (decreases guanine synth)

-interferes with mRNA capping and RNA pol

*Teratogen (dont use with pregnancy)

Immunomodulatory antiviral

INFa for chronic HepB and C, Kaposi Sarcoma

*^efficacy with Ribavirin

*myelosuppression, neutropenia

rationally designed Anti-AIDS

-binds gp41 (blocks viral binding to CD4 cells)

Anti-HIV drug

-Nucleoside reverse transcriptase inhibitor

-Suppresses HIV infection (reduces HIV transmission to fetus in pregnancy)

*granulocytopenia, seizures, muscle pain and weakness

-very lipophilic (activated by cell enzymes)

Anti-HIV (Non-nucleotide RT inhibitor)

-non-competitive inhibitor of RT

Anti-HIV (protease inhibitor)

-CYP3A4 metabolized

*Buffalo hump, periph wasting, hyperglycemia