Term
|
Definition
Guanine analogue, chain termination
activated by viral thymidine kinase
HSV 1,2; VZV |
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Term
|
Definition
Guanine analogue, chain terminatino
converted to acyclovir in blood
HSV 1,2; VZV |
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Term
|
Definition
guanine analogue, oral pro-drug of penciclovir
HSV 1,2; VZV |
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Term
|
Definition
inhibits CMV DNA polymerase
chain termination
CMV
bone marrow and kidney toxic |
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Term
|
Definition
acyclic cytosine analogue, chain termination and inhibition of viral DNA polymerase
herpesviruses, esp. acyclovir resistant
nephrotoxic |
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Term
|
Definition
pyrophosphate analogue
chain termination, complex with dna polymerase
herpesviruses, esp. acyclovir resistant |
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Term
|
Definition
guanosine analogue
many dna and rna, RSV, Hep C, lassa fever |
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Term
|
Definition
M2 protein of influenza A
interferes with ion channel and uncoating
insomnia, dizziness, difficulty concentrating |
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Term
|
Definition
neuraminadase inhibitor
influenza a and b |
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Term
|
Definition
glycoprotein
activates ribonuclease, inactivate initiation factor, enhance APC
chronic hep b and c |
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Term
|
Definition
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Term
|
Definition
efavirenz, nevirapine, delavirdine
bind active site of reverse transcriptase
resistance develops quickly
HIV |
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Term
| protease inhibitors (name them) |
|
Definition
end in -navir
inhibits maturation by preventing cleavage of polyproteins
HIV |
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Term
|
Definition
fusion inhibitors
blocks conformational change in gp-41
HIV
IM injection rxn, GI intolerance, hypotension, pruritis |
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Term
|
Definition
CCR5 inhibitor
hepatotoxicity, cough, pyrexia, URI, rash, musculoskeletal pain, abdominal pain, dizziness |
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