Term
| binds to viral surface protein and locks it into conformation that is inactive in fusing with the host cell membrane |
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Definition
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Term
| how do most viruses enter cells? |
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Definition
|
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Term
| how do anti-influenza drugs work? |
|
Definition
| by inhibition of viral uncoating |
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Term
| these drugs prevent the viral acidification by blocking the viral M2 protein |
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Definition
| anti-influenza agents mechanism of action |
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Term
| these are specific for influenza A |
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Definition
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Term
| How do anti-herpes virus agents (nucleoside analogs) work |
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Definition
| inhibition of viral genome replication |
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Term
| Used for Herpes Simplex Virus and Varicella-zoster virus by inhibiting viral replication |
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Definition
|
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Term
| this drug is actually a prodrug that is converted to acyclovir in this intestine. but may cause nephrotoxicity, diarrhea, headache |
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Definition
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Term
| this nucleotide analog is selectiviely toxic for HSV infected cells because the viral thymidine kinase protein made in the infected cell is necessary to activate the drug |
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Definition
|
|
Term
| viral thymidinie kinase can mutate rapidly to render this herpes drug ineffective |
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Definition
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Term
| this is used in acyclovir-resistant mucocutaneous HSV infections in patients with AIDS and is administered via an eye drop |
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Definition
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Term
| this antiviral works by inhibiting viral dna polymerase, but also may inhibit hose cellular dna polymerases |
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Definition
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|
Term
this drug is already phosphorylated, so it does not require TK or other kinases.
-Effective against mutant viruses |
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Definition
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Term
|
Definition
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Term
|
Definition
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Term
| Anti- HIV nucleotide analogs: |
|
Definition
nucleotide reverse transcriptase inhibitors
non nucleotide reverse transcriptase inhibitors |
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Term
| Anti- HIV drug that inhibits the conversion of RNA genomes into DNA by preventing reverse transcriptase enzymes |
|
Definition
| Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI) ex: AZT |
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Term
|
Definition
| non-nucleoside/nucleotide reverse transcriptase inhibitor |
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|
Term
inhibits viral DNA and RNA polymerases : HIV, HSV, CMV
-viral polymerases more sensitive |
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Definition
| non nucleoside/nucleotide reverse transcriptase inhibitor (foscarnet) |
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Term
| used for viruses resistant to nucleoside/nucleotide analogs |
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Definition
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Term
| these bind to viral proteases and inactivate them, therefore long viral polypeptides fail to be processed to functional proteins |
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Definition
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|
Term
zanamivir (relenza)
oseltamivir (tamiflu) |
|
Definition
| ihbitors of viral release |
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|
Term
| combination therapy for HIV: |
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Definition
|
|
Term
| what is the advantage of HIV combination therapy? |
|
Definition
more efficacious at lower doses
reduced toxicity |
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Term
| 1st choice of treatment for H1N1 |
|
Definition
| neuraminidase inhibitor: zanamavir, oselotamivir |
|
|
Term
| choice of treatment for H1N1 if first choice is resistant |
|
Definition
| Amantadine and Ramantidne |
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|
Term
| major side effect of tamiflu |
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Definition
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