PO; excreted in urine (unchanged)

           --requires dosage adj. for renal         impairment

uses: influenza A

-prophylactic

-can treat & vaccinate simultaneously

-initial therapy for Parkison's

crosses BBB -> Dopamine release

     *CNS side effects

PO; extensively metabolized

ticyclic amine (blocks viral uncoating)

uses: influenza A

-prophylactic

-treat and vaccinate at same time

inhaled; 90% urinated unchanged

neuraminidase inhibitor

(decr. virus relase/incr. viral aggregation)

uses: influenza A & B

-early admin. best (48hr)

-decr. influenza complications

well absorbed; urinated unchanged

neraminidase inhibitor

(decr. viral release/incr. viral aggregation)

uses: influenza A & B

-best when admin early (48hr)

-decr. complications

-nausea/vomitting (15%)

Ribavirin

aerosol (NOT PO)

nucleoside analogue

-inhib viral RAN pol, GTP syn

-block mRNA capping

uses: influenza A&B

-respiratory syncytial virus

-viral hep

-hemolytic anemia

-decr. resistance

IV, topical, PO; glomerular filtered, some metabolism

Nucleoside analogue

-inhib viral DNA pol

-terminates elongation

uses: HSV 1 & 2

-mucocutaneous infections (immunocompromised)

-varicella-zoster

-resistant strains

topical

nucleoside analogue

uses: herpes keratitis

-topical 

large dose PO

nucleoside analogue

uses: neonatal herpes

-large, oral doses

ganciclovir

(acyclovir + CH2OH)

-IV (acute), oral (maintainance)

nucleoside analogue

uses: CMV @ kidney transplant pt

-bone marrow suppression

-CNS effects

IV

nucleoside analogue

uses: CMV retinitis @ ganciclovir resistant

-IV

-bone marrow, renal toxicity

IV

pyrophosphate analogue

uses: CMV retinitis @ ganciclovir resistance 

-also works agianst Herpes and HIV

-more expensive but better tolerated

-decr. renal function

IM, subQ, topical

glycoproteins

uses: chronic Hep B & C

-genital warts

-herpes zoster

-given with ribavirin

causes neutropenia -> flu like symptoms