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Antivirals
NUR 326 (Test 4)
111
Science
Undergraduate 3
04/01/2008

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Term
HIV Drugs
Definition
Reverse trasnscriptase inhibitors
Prevent transcription of RNA to DNA
Term
Protease Inhibitor
Definition
Prevent viral mutation
Term
Fusion Inhibitor
Definition
Prevent viral fusion to the host cell membrane (can prevent transmission)
Term
Decrease vertical transmission of HIV
Definition
Effective therapy
Elective c-section
Formula feeding
Term
HAART
Definition
Highly active antiretroviral therapy
3 or more drugs
Term
Dermatophytes
Definition
Superficial skin infections of skin, hair, and nails
Term
Antifungal drugs
Definition
Disrupting structure and function of various fungal cell components
Term
Antineoplastic drugs
Definition
Kill malignant cells during cell's reproductive cycle
Term
Tumor Lysis Syndrome
Definition
When malignant cells are killed, they release their contents into the bloodstream causing many problems
Term
Antiestrogens
Definition
Block estrogen which can provoke breast cancer
Term
Luetinizing hormone releasing hormone (LHRH)
Definition
Stops all hormone production
Term
Valtrex
Definition
Anti-viral
Term
Valtrex MOA
Definition
Inhibits viral DNA reporduction
Term
Indications of Valtrex
Definition
Genital Herpes
Herpes Zoster
Term
Acyclovir MOA
Definition
Inhibits viral DNA reproduction
Term
Indications for Acyclovir
Definition
Genital Herpes
Herpes Simplex
Term
AE for Acyclovir
Definition
Renal failure
Term
Acyclovir
Definition
Anti-viral
Term
Cytovene
Definition
Anti-viral
Term
Cytovene MOA
Definition
Inhibits viral reproduction
Crosses BBB
Term
Indications for Cytovene
Definition
CMV retinitis (commonly seen in AIDS)
Term
AE of Cytovene
Definition
Decreased visual acuity
Vitreous hemorrhage
Term
Teaching for Cytovene
Definition
Take with food
Soft toothbrush and electric razor
Term
Ribavirin
Definition
Anti-viral
Term
Ribavirin MOA
Definition
Inhibits viral synthesis and replication
Term
Indications for Ribavirin
Definition
Pneumonia caused by RSV
Bronchiolitis (inhlation in hospitalized children)
Chronic Hepatitis C
Term
Symmetrel
Definition
Anti-viral
Anti-Parkinson's
Term
Symmetrel MOA
Definition
Inhibits replication of influenza A virus
Term
Indications for Symmetrel
Definition
Prophylaxis in high risk patients
Treats (given to those exposed to prevent from getting sick)
Parkinson's Disease
Term
AE for Symmetrel
Definition
Ataxia
Insomnia
Mottling
Term
Teaching for Symmetrel
Definition
Must treat early (within 2 days)
Good oral hygiene (decrease mouth dryness)
Term
Viread
Definition
Anti-retroviral
Nucleotide
Term
AE of Viread
Definition
Hepatomegaly
Lactic acidosis
Term
Teaching for Viread
Definition
Increase of fat in upper back, neck, breast and trunk
Decrease of fat in arms, legs, and face
Term
AZT
Definition
Anti-viral
Nucleoside
Term
Indications for AZT
Definition
Only anti-retroviral drug approved for pregnancy
Term
AE of AZT
Definition
Pancreatitis
Anemia and granulocytopenia
Peripheral neuropathy
Term
Teaching for AZT
Definition
Take around the clock even if sleep is interrupted
Term
Rescriptor
Definition
Anti-retroviral
Non-nucleoside
Term
AE of Rescriptor
Definition
Induces drug metabolism in the liver
Term
CI for Rescriptor
Definition
Use of benzodiazpines, antiarrhythmics, calcium channel blockers, and amphetimines
Term
Viracept
Definition
Anti-retroviral
Protease Inhibitor
Term
Viracept MOA
Definition
Metabolized by the P450 system
Decreases metabolism of other drugs
Term
CI of Viracept
Definition
Cautiously in liver impairment
Term
Teaching for Viracept
Definition
Take at the same time every day
May cause hyperglycemia
Term
Fuzeon
Definition
Anti-retroviral
Fusion Inhibitor
Term
Indications for Fuzeon
Definition
Combination drug to decrease pill burden
Term
AE of Fuzeon
Definition
Fatigue
Injection site reactions
Term
Teaching for Fuzeon
Definition
Must take with other anti-retroviral drugs
Term
Fungizone
Definition
Anti-fungal
Term
Fungizone MOA
Definition
Binds to cell wall, allowing leakage of cellular contents
Term
CI of Fungizone
Definition
Pregnancy, lactation, and small children (toxic to human cells)
Term
AE of Fungizone
Definition
Nephrotoxicity
Hypotension
Hypokalemia
Term
Teaching for Fungizone
Definition
PO: swish as long as possible
Topical: may stain clothing
Term
Difulcan
Definition
Anti-fungal
Term
Diflucan MOA
Definition
Inhibits synthesis of fungal sterols
Term
Indications for Diflucan
Definition
Most commonly used anti-fungal
Vaginal infections (one dose only)
Term
AE of Diflucan
Definition
Stevens-Johnson syndrome
Term
Teaching for Diflucan
Definition
Take at the same time every day
If only in mouth, swish and spit
Term
Cancidas
Definition
Anti-fungal
Echinocandins
Term
Cancidas MOA
Definition
Inhibits synthesis of beta-D-glucon
Term
Aralen
Definition
Anti-malaria
Anti-rheumatic
Term
Indications for Aralen
Definition
Prophylaxis or treatment of acute attacks of malaria
Term
AE of Aralen
Definition
Aplastic anemia
Leukopenia
Agranulocytosis
Term
Teaching for Aralen
Definition
Minimize exposure to mosquitoes
Avoid alcohol
Term
Vermox
Definition
Anti-helmintic
Term
Vermox MOA
Definition
Generally long acting
Kills the worm but have to take a laxative to get rid of the worm
Term
Indications for Vermox
Definition
Take chewable or crushed
Term
Nix
Definition
Pediculocide
Term
Nix MOA
Definition
Paralyzes lice
Term
Indication for Nix
Definition
Getting rid of lice and scabies
Term
AE of Nix
Definition
Burning
Itching
Stinging
Term
Teaching for Nix
Definition
Don't get in eyes
Check others in house for lice
Notify child's school
Term
Platinol
Definition
Alkylating Agent
Antineoplastic
Term
Platinol MOA
Definition
Non cell-cycle specific
Term
Teaching for Platinol
Definition
Usually given when someone comes into the hospital - not routine
Give Mannitol to push drugs through Foley - HYDRATE!
Term
Adriamycin
Definition
Anrhracyclines
Anti-neoplastic
Term
Adriamycin MOA
Definition
Cell-cycle S specific
Term
Adriamycin Indications
Definition
Bronciogenic carcinoma
HIGH ALERT
Term
Teaching for Adriamycin
Definition
Careful handling bodily fluids
Term
AE of Adriamycin
Definition
Cardiomyopathy
Red urine
Term
Blenoxane
Definition
Antitumor antibiotic
Anti-neoplastic
Term
Indications for Blenoxane
Definition
HIGH ALERT
Squamous cell carcinoma
Teratocarcinoma
Chariocarcinoma
Term
AE of Blenoxane
Definition
Vesicant
Term
Teaching for Blenoxane
Definition
No smoking
Term
Taxol
Definition
Taxoid
Anti-Neoplastic
Term
Taxol MOA
Definition
Cell-cycle specific (mitosis and interphase)
Term
Indications for Taxol
Definition
Karposi's sarcoma in AIDS
Term
AE of Taxol
Definition
Arthralagia
Myalgia
Term
Rituxan
Definition
Monoclonal antibodies
Anti-neoplastic
Term
Rituxan MOA
Definition
Bind to growth factors or growth receptors
Term
Indications for Rituxan
Definition
non-Hodgkin's lymphoma
Term
CI for Rituxan
Definition
Hypersensitivity to murine (mouse) protein
Term
AE for Rituxan
Definition
Tumor lysis syndrome
Term
Velcade
Definition
Protease Inhibitor
Anti-neoplastic
Term
Velcade MOA
Definition
Multiple mechanisms of cytotoxicity
Term
Inidcations for Velcade
Definition
Multiple myeloma progressing after at least one other therapy
Term
CI of Velcade
Definition
Hypersensitivity to Mannitol
Term
AE of Velcade
Definition
Dehydration
Term
Teaching for Velcade
Definition
Dehydration may occur from N/V
Term
Nolvadex
Definition
Anti-estrogen
Anti-neoplastic
Term
Nolvadex MOA
Definition
Blocks estrogen which can provoke breast cancer
Term
Indications for Nolvadex
Definition
Prevention of breast cancer in high risk
Prevents reoccurance
Used for 5 years
Term
CI of Nolvadex
Definition
Use of Warfarin with history of DVT
Term
AE of Nolvadex
Definition
Blood clot
Hot flashes
Endrometrial cancer
Term
Teaching for Nolvadex
Definition
May induce ovulation
Teratogenic effects
Term
Lupron
Definition
LRHR
Anti-neoplastic
Term
Lupron MOA
Definition
Stops all hormone production
Term
Indications for Lupron
Definition
Advanced prostate cancer
Endometriosis
Term
AE of Lupron
Definition
Hot flashes
Impotence
Term
Teaching for Lupron
Definition
Amenorrhea is expected
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