Shared Flashcard Set

Details

Antivirals
Pharm 2 Exam 1
30
Health Care
Graduate
02/03/2009

Additional Health Care Flashcards

 


 

Cards

Term
Oseltvamivir and Zanamavir MOA
Definition

Neutraminidase inhibitors

(no new virons)

Term
Actions/Use of Oseltamivir/Zanamivir
Definition

Flu A and B w/ no interaction w/ vaccine for A

Term
Administration of Oseltamivir
Definition
 oral before or 24-48 hrs after exposure
Term
Admin. of Zanamivir
Definition
inhalation before or w/i 24-48 hrs after exposure
Term
AE Oseltamivir
Definition
GI -> take w/ food
Term
AE Zanamivir
Definition
bronchospasm in pts w/ resp dz
Term
Amantidine/Rimantidine MOA
Definition

Block ‘uncoating’ of the

virus within the host cell

Term

actions/uses for amantidine/rimantidine

Definition

Flu A ORALLY before-> decr severity and length

 

can be supplement to vaccine in at risk pts.

Term
Distribution/metabolism of Amantidine/Rimantidine
Definition

Amantidine>>Rimantidine w/ BBB

 

Amantidine NOT metabolized; Rimantidine EXTENSIVELY metabolized

Term
AE Amantidine/Rimantidine
Definition

Amantidine>>>Rimantidine CNS

 

Rimantidine >>>Amantidine GI

Term
Ribavirin MOA
Definition
Interferes w/ duplication of viral DN for RSV
Term
Administration of Ribavirin
Definition
 oral and IV with fatty meal
Term
AE Ribavirin
Definition

Anemia

 

decr resp fxn after tx

Term
who should be prescribed Ribavirin
Definition

infants and kids w/ SEVERE RSV

 

NOT ADULTS!!

Term
Interferon alpha 2-b MOA
Definition

Glycoprotein that decreases virus’

ability to invade the host cells &

inhibits viral RNA.

Term
Hep B tx
Definition
Interferon + Lamivudine
Term
Hep C tx
Definition
Interferon + Ribavirin
Term
AE Interferon
Definition

flu-like

CNS

bone marrow suppression

thyroiditis

Term
Acyclovir actions/uses
Definition

HSV-1, 2, VZV, Epstein Barr

Term
most commonly used drug to tx genital herpes
Definition
acyclovir
Term
DOC for herpes encephalitis
Definition
acyclovir
Term
AE acyclovir
Definition

Renal comp w/ IV

GI, HA w/ PO

local irritation w/ topical

Term
Cidofovir MOA
Definition

Inhibits DNA synthesis

Term
Cidofovir used to tx
Definition
CMV
Term
AE cidofovir
Definition

Renal

neutropenia

metabolic acidosis

Term
foscarnet MOA
Definition

Inhibits viral enzymes

Term
foscarnet used to tx
Definition

CMV retinitis

Acyclovir resistant HSV

Term
AE foscarnet
Definition

nephrotoxicity

electrolyte imbalances

Term
Glancyclovir uses
Definition

CMV retinitis – immune comp pts

CMV pneumonitis - transplant pts

Term
AE Glancyclovir
Definition
severe neutropenia
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