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Antiviral, Antifungal, Anti inflammatory
Terms, definitions associated with viral, fungal, and inflammatory infections
28
Nursing
Professional
02/23/2013

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Term
Antiviral agents
Definition
INFECTION/INFLAMMATION: destroys or prevents replication of viruses, by blocking a polymerase enzyme needed to make new genomes. Decreases viral load enough so that the host immune system can fight it more effectively
Term
Antifungal agents
Definition
INFECTION/INFLAMMATION: treat fungal infections
Term
Antiinflammatory agents
Definition
INFECTION/INFLAMMATION: Reduce fever, inflammation, and pain
Term
Antirheumatoid agents
Definition
INFECTION/INFLAMMATION: Treat rheumatic conditions of gout and arthritis
Term
Immunizing agents
Definition
IMMUNE/CANCER: toxoids or vaccines that target a specific infectious microorganism
Term
Cell-mediated immunity
Definition
Non-specific immune responses mediated primarily by T cells and other immune cells (monocytes, macrophages, neutrophils).
Term
Humoral immunity
Definition
Specific immune responses in the form of antigen-specific antibodies produced by B lymphocytes.
Term
Antigen
Definition
A foreign substance, usually a protein, that causes the formation of an antibody.
Term
Viruses
Definition
Smallest known class of microorganisms; viruses can only replicate inside host cell.
Term
Influenza viruses
Definition
Viruses that cause an acute viral infection of the respiratory tract. 3 types: A, B, C...meds only available for A and B.
Term
Acyclovir
Definition
Tx-herpes viruses: HSV-1, HSV-2, herpes zoster and chicken pox; SE-GI, headache, transient burning when applied topically. Encourage fluids, oral with food, use large veins IV route, monitor liver/renal function
Term
Ribavarin
Definition
Tx- respiratory syncytial virus (RSV); SE-rash, conjunctivitis, anemia, mild bronchospasm; Teratogenic potential; Encourage fluids, oral with food, use large veins IV route, monitor liver/renal function
Term
Amantadine
Definition
Tx-Influenza A; SE-anticholinergic effects, GI, orthostatic hypotension, lightheadedness; not used in children <12 months, those w/eczema, or lactating women; Encourage fluids, oral with food, use large veins IV route, monitor liver/renal function
Term
Oseltamivir, zanamivir
Definition
Tx-influenza A and B; SE-GI, sinusitis; Encourage fluids, oral with food, use large veins IV route, monitor liver/renal function
Term
Cidovir
Definition
Tx-CMV (cytomegalovirus), common in immunosuppressed individuals; SE-renal function; Encourage fluids, oral with food, use large veins IV route, monitor liver/renal function
Term
Polyenes
Definition
Bind to sterols in cell membranes of fungi, altering cellular metabolism, leading to cell death.
Term
Amphotericin B
Definition
Polyene, Broad-spectrum; Tx-serious systemic infections; SE-horrible chills, fever, nephrotoxicity, neurotoxicity, extreme irritation to veins, cardiac dysrhythymia, potassium loss; use with antihistamines, antipyretics, antiemetics,
Term
Nystatin
Definition
Polyene; Tx-candidal diaper rash, vaginal candidiasis; SE-GI, rash, hives; administered orally, topically; yellow in color
Term
Ketoconazole, fluconazole
Definition
Fungistatic or fungicidal, based on concentration levels; fluconazole crosses B.B. barrier; Tx-ketoconazole (dermatophytes), fluconazole (cryptococcal meningitis, candida infections); SE-headache, GI, bone marrow suppression, hepatic/renal,
Term
Inflammation
Definition
Response to injury or infectious agent, generally localized in nature.
Term
NSAIDS (nonsteroidal antiinflammatory drugs)
Definition
Large & chemically diverse group of drugs that possess analgesic, antiinflammatory, antirheumatic, and antipyretic activity. SE-allergic reaction, GI, hematologic, hepatic/renal function decrease, tinnitus,
Term
Colchicine
Definition
Antigout; reduces inflammation r/t deposits of gout crystals; Tx-acute gout attacks; SE-leukopenia, bleeding in GI or Urinary tract, GI issues; take on empty stomach
Term
Allopurinol
Definition
Antigout; inhibits uric acid production; SE-agranulocytosis, aplastic anemia, potentially fatal skin conditions; take with meals
Term
Probenecid
Definition
Uricosic, increases excretion of excess uric acid; SE- GI;
Term
Sulfinpyrazone
Definition
Uricosic, increases excretion of excess uric acid; SE- ulcerogenic, bone marrow suppression
Term
Disease-modifying antirheumatic drugs (DMARDs)
Definition
Medications used in treatment of rheumatic diseases that have the potential to arrest or slow the actual disease process. They exhibit antiinflammatory, antiarthritic, and immunomodulating effects, which work by inhibiting movement of cells (neutrophils, monocytes, & macrophages) into an inflamed, or damaged area.
Term
Rheumatism
Definition
Any of several disorders characterized by inflammation, degeneration, or metabolic derangement of connective tissue structures.
Term
Rheumatoid arthritis
Definition
A chronic autoimmune disorder that commonly causes inflammation and tissue damage in joints.
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