• Anti-influenza drug
• inhibit viral protein translocator which acidifies the core of the viral particle
• prevents unpackaging
• oral, 20hr, renal elimination
• Used with L-dopa for parkinsons; most flu strains resistant

• Neuraminidase inhibitor
• Prevent viral release, limit spread, reduce epithelial cell apoptosis
• Used for Influenza A & B, some H5N1 resistant
• prophylaxis 70-85% effective; reduces symptoms when given w/in 30 hr of infection
• nontoxic; Nausea, vomiting, headache

• Thymidine analog
• Phosphorylated by TKs and incorporated
• Changes pKa of H in base pairing->mutation, alters DNA conformation, DNA breakage
• Mutagenic, carcinogenic, teratogenic
• Used topically only: HSV, keratitis

• Mech:Acyclo-dGTP compet inhib dGTP @ DNAP, Chain terminator when incorporated
• Oral or iv, 3 hr, urinary excretion
• Wide distribution, including CNS
• Low toxicity, no bone marrow suppresion
• Use: HSV1,2, EBV, not for CMV

• phosphorylated by cellular and HSV TKs
• More actively phosphorylated in infected cells
• Comp inhib dGTP incorp by DNAP, term chain
• Not as specific as acyclovir
• Valgancyclobir=prodrug, increases absorption
• IVm 3-4hr renal elimination
• bone marrow depression, nephrotoxic, GI
• Use: CMV, retinitis, all HSV(2nd line) 

• Guanosine nucleoside analog
• Inhibits HBV: DNAP base pairing, RT on the (-) strand, syn of (+) strand of HBV DBA
• Renal elim
• Headache, fatigue, N,V, vertigo, cancer in animals, lactic acidosis, hepatomegally
• Use: Hep B, severe excacerbation if discontinue

• phosphorylated and a substrate for hepadnavirus DNAP>host DNAP, incorp into viral DNA acting as chain terminator
• Renal elim
• Nephrotoxic, lactic acidosis, hepatic steatosis if used with NRTIs for HIV
• Use: Hep B

Ribavirin

• Reduces GTP synthesis and inhibits viral RNAP
• Inhibits mRNA guanyltransferases, labilizes viral mRNA by reducing 5' cap formation
• Oral, IV, aerosol, t1/2=2 hr, hepatic metab, urine elim
• bone marrow depression, GI, CNS, teratogenic, mutagenic, carcinogenic
• Use: Hantaan RSV bronchiolitis, pneumonia, +interferon alpha for Hep C

• Acyclovir analog
• Use: HSV1, 2, EBV

• Acyclovir prodrug