Term
| What are the five first-line anti-TB drugs? |
|
Definition
| Rifampin, Ethambutol, Streptomycin, Pyrozinamide, and Isoniazid |
|
|
Term
| What must be given in conjunction with isoniazid? |
|
Definition
|
|
Term
| What are the three major toxicities associated with isoniazid? |
|
Definition
| Hepatotoxicity, Neurotoxicity (Reduce with pyridoxine), and CNS toxicity |
|
|
Term
| What toxicity associated with rifampin is considered to be "uncommon" but still is told to the patient? |
|
Definition
|
|
Term
| What is considered the most important side-effect of rifampin? |
|
Definition
| It causes drug interactions. |
|
|
Term
| For individuals taking pyrazinamide, besides the hepatotoxicity, what other adverse effect could they have possibly? |
|
Definition
| elevated uric acid concentrations |
|
|
Term
| When taking ethambutol, how does the dosing get set? |
|
Definition
| It's adjusted according to the degree of renal insufficiency in the patient- also to ensure that ocular toxicity is avoided |
|
|
Term
| In a 6 month plan for treating TB, what three drugs must be taken together each day for at least 8 weeks? |
|
Definition
| Rifampin, Isoniazid, and Pyrazinamide |
|
|
Term
| What are the three major second-line agents that we must pay attention to ? |
|
Definition
| the quinolone class, amikacin, and capreomycin |
|
|
Term
| For MDR-TB or suspicion of MDR-TB, what's the recommended treatment regimen? |
|
Definition
| 5-6 or more drugs initially and then accordingly adjust once susceptibilities are known |
|
|
Term
| What type of TB is not common in HIV patients? |
|
Definition
|
|
Term
| What the criteria for airborne isolation? |
|
Definition
| abnormal CXR and any suspicion of active TB in the patient |
|
|
Term
| Which one of the first-line TB drugs is NOT hepatotoxic? |
|
Definition
|
|
Term
| Is ethambutol bacteriostatic or bactericidal? |
|
Definition
|
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