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Antipsychotics and Antidepressants
Review of classes of antipsychotic and antidepressant drugs (for the tricyclic drugs, 2nd and 3rd indicates whether the amine group is secondary or tertiary)
44
Pharmacology
Graduate
10/25/2009

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Term
Haloperidol
Definition
High potency typical antipsychotic
Term
Fluphenazine
Definition
High potency typical antipsychotic
Term
Pimozide
Definition
High potency typical antipsychotic
Term
Thiothixene
Definition
High potency typical antipsychotic
Term
Trifluoperazine
Definition
High potency typical antipsychotic
Term
Perphenazine
Definition
Mid potency typical antipsychotic
Term
Molindone
Definition
Mid potency typical antipsychotic
Term
Loxapine
Definition
Mid potency typical antipsychotic
Term
Chlorpromazine
Definition
Low potency typical antipsychotic
Term
Mesoridazine
Definition
Low potency typical antipsychotic
Term
Thioridazine
Definition
Low potency typical antipsychotic
Term
Clozapine
Definition
Atypical antipsychotic
Gold standard
Wide antagonism
Term
Risperidone
Definition
Atypical antipsychotic
Most "typical" of atypicals (EPS possible)
Depot formulation like haloperidol and fluphenazine
Term
Quetiapine
Definition
Atypical antipsychotic
Sedating
Orthostatic hypotension
Term
Olanzapine
Definition
Atypical antipsychotic
Second-most effective after clozapine
Highest metabolic symptoms
Term
Ziprasidone
Definition
Atypical antipsychotic
Prolonged QT interval
Term
Aripiprazole
Definition
Atypical antipsychotic
Antagonist at 5HT2A, partial agonist at D2 and 5HT1A
Term
Paliperidone
Definition
Atypical antipsychotic
Metabolite of ripseridone
Term
Iloperidone
Definition
Atypical antipsychotic
Lowest weight gain?
Possible prolonged QT interval
Term
Asenapine
Definition
Atypical antipsychotic
Novel mechanism of action
Term
Amitripyline
Definition
Tricyclic, 3rd
Used for pain, headache, insomnia
Term
Clomipramine
Definition
Tricyclic, 3rd
Highly serotonergic
Indicated for OCD
Term
Doxepin
Definition
Tricyclic, 3rd
Used for pain, insomnia, anxiety
Term
Trimipramine
Definition
Tricyclic, 3rd
Term
Imipramine
Definition
Tricyclic, 3rd
Used for panic, enuresis
Term
Desipramine
Definition
Tricyclic, 2nd
Demethylated imipramine
Least acetylcholinergic
Term
Nortripyline
Definition
Tricyclic, 2nd
Demethylated amitriptyline
Least orthostasis
Term
Protrypiline
Definition
Tricyclic, 2nd
Term
Phenelzine
Definition
MAOI
Term
Tranylcypromine
Definition
MAOI
Term
Selegiline
Definition
MAOI
Patch form
Lower dietary restrictions at lower doses
Term
Fluoexetine
Definition
SSRI
Longest t1/2
Efficacy in bulimia
Term
Paroxetine
Definition
SSRI
More sedating than fluoxetine or sertraline
Term
Sertraline
Definition
SSRI
Less sedating than paroxetine
Term
Fluvoxamine
Definition
SSRI
Indicated for OCD
Term
Citalopram
Definition
SSRI
Term
Escitalopram
Definition
SSRI
Term
Venlafaxine
Definition
SNRI
Superior efficacy for depression among all antidepressants
Term
Duloxetine
Definition
SNRI
Nausea common
Used for diabetic neuropathy
Term
Desvenlafaxine
Definition
SNRI
Metabolite of venlafaxine
Term
Mirtazapine
Definition
NaSSA
Also blocks 5HT2A, 5HT3, 5HT2C, and H1 receptors
Term
Trazodone
Definition
SARI
Term
Nefazodone
Definition
SARI
Term
Bupropion
Definition
Noradrenergic and dopamine reuptake inhibitor
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