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antipsychotic pharmacology
Some pharmacology cards on antipsychotics
48
Pharmacology
Professional
03/02/2011

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Cards

Term
What are the positive symptoms of schizophrenia
Definition
Deluxions, Hallucinations, disorganized speech, and catatonic behavior
Term
What are the negative symptoms of schizophrenia
Definition
Affective flattening, alogia, and avolition
Term
Which parts of the brain are affected in schizohrenia?
Definition
Mesocortical and mesolimbic
Term
Which part of the brain causes positive symtoms of schizophrenia?
Definition
mesolimbic
Term
What do anytipsychotic drugs end in?
Definition
~azine or ~thixene or ~peridol. Also Loxapine, Molindone, and Pimozide
Term
Which receptor do typical antipsychotics work on?
Definition
D2
Term
What do atypical antipsychotics end in?
Definition
~idone or ~apine, also Aripiprazole
Term
True or false: typical antipsychotics are better at controlling the positive effects of schizophrenia
Definition
1
Term
Which of the following is NOT a theory of how Antipsychotic agents work? A: They antagonize 5-HT2 AND D2, B: They selectively inhibit D2 AND D4, C: They Inibit D4 but agonize 5-HT-2 or D They rapidly dissociate from D2 receptrs
Definition
C. They do not agonize 5-HT-2
Term
Which receptor causes extrapyramidal effects?
Definition
Antagonism of D2
Term
What effects are collectively known as extrapyramidal effects?
Definition
Acute dystonia, akatheisia, Parkinsonism, Rabbit Syndrome, Tardive dyskinesia
Term
When does Acute dystonia show up?
Definition
1-5 days
Term
when does Akathisia show up?
Definition
5-60 days
Term
When does Parkinsonism show up?
Definition
5-30 days
Term
When does Rabbit syndrome show up?
Definition
after months or years of treatment
Term
When does Tardive dyskinesia show up?
Definition
after months or years of treatment
Term
Which atypical antipsychotic has the most EPS effect?
Definition
Risperdone
Term
Which antipsychotic has the LEAST side effects?
Definition
Aripiprazole
Term
What are the typical antipsychotic drugs?
Definition
Haloperidol, Fluphenazine, Thiothixine, Trifuoperazine, Chloropromazine, Mesoridazine, Thioridazine. HAL Flew Thith Train. Catch me the rest
Term
What are the atypical antipsychotic drugs?
Definition
Risperidone, Ziprasidone, Clozapine, Aripiprazole, Quetiapine, Olanzapine. Rip, Zip, ClAP. Quiet! Olan.
Term
Based on the order given in our chart, which drugs have the most EPS effects?
Definition
Highest at top, lowest at bottom. Halo to Thioridazine
Term
According to our chart, which atypical drugs have the most EPS?
Definition
Risperdone
Term
According to our chart, which typical drugs are most sedating?
Definition
The bottom ones are. Chloro, Meso, and Thio
Term
According to our chart, which aytpical drugs are the most sedating?
Definition
It makes a suspension bridge. Clozapine and Quetiapine are the worst. Olan and Arip are the best
Term
According to our chart, which typical drugs have the most hypotensive effects?
Definition
Bottom Heavy. Chloro, meso, and Tioridiazine
Term
Which atypical drugs have the most hyptensive effects?
Definition
All are pretty equal except for Aripiprazole.
Term
Which drugs can cause QT prolongation?
Definition
Thioridazine, Mesoridazine, Halopiriidol, and Ziprasidone. QT prolongation can kill you. Hail Mary, Zip the rest.
Term
Which drug is associated with agranulocytosis?
Definition
Clozapine
Term
Which drugs make you gain weight?
Definition
Clozapine and Olanzapine. Cl olan (clown) around, and gain weight
Term
Which drugs are NOT associated with weight lost
Definition
Aripiprazole and ziprasidone. They make you zipped and ripped.
Term
What is an unusal side effect of antipsychotics?
Definition
hyperprolatinemia. You make more prolactin on old drugs and risperdone
Term
Which drug causes poikilothermic effect?
Definition
Chlorpromazine. (eleveated body temperature)
Term
Which OTHER drugs cause QT elongatoin?
Definition
Sotalol, Dofetiilide, Quinidine, Quinolones, Macrolides. So Don't Mack on Quin Quin
Term
What are the two most important functions of the Noradrenergic system?
Definition
Stress responses and pain control
Term
Which receptors increase cAMP?
Definition
5HT 4, 5, and 6
Term
Which receptors decrease cAMP?
Definition
5HT 1A, 1B, and 1D
Term
Which receptors increase IP3?
Definition
5HT 2A, 2B, and 2C
Term
Which Receptrs are ligand gated ion channels?
Definition
5HT3
Term
How long must depression go on to be considered major?
Definition
two weeks or longer
Term
What does typical depression respond well to?
Definition
SSRIs
Term
True or false: Patients with atypical depression respond well to SSRI therapy.
Definition
False. MAOIs are best, but that's not considered firstline therapy.
Term
What do you use for atypical depression?
Definition
buproprion, vanlafaxine, and mehtylphenadate
Term
What is the most severe type of depression?
Definition
Melancholic depression
Term
What do you give a person with melancholic depression
Definition
SSRIs, mirtazapine, or maybe TCAs
Term
How long until MAOIs start to work?
Definition
3 or more weeks
Term
What is the effect of stimulating auto receptors?
Definition
They inhibit postsynaptic signaling
Term
What is the net effect of antidepressant drug therapy?
Definition
Even though autoreceptors are activated, post-synaptic signaling is increased.
Term
What is the longterm effect of antidepressant therapy?
Definition
Auto receptors are down regulated and post-synaptic signaling goes way up
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