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Antihypertensives
drugs that decrease blood pressure and heart rate
7
Pharmacology
Undergraduate 4
01/31/2013

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Cards

Term
ACE inhibitors
Definition
end in -pril
decrease blood pressure
decrease aldosterone (sodium/fluid loss)

for CHF & HTN

gastric irritation, MI, hypotention, proteinuria, rash, pruritis, cough, peripheral edema

do NOT take with food
frequent mouth care
used with thiazide diuretics
Term
Beta blockers
Definition
ends in -lol
decreases beats, blood pressure
(decreases workload and O2 consumption)

helps with migraines and stage fright

gastric pain, impotence, bronchospasm, nightmares, heart failure dysrhythmias, blocks hypoglycemia signs

TAKE WITH MEALS
Term
Calcium-channel blockers
Definition
Amlodipine (A)
Verapimil (Very)
Nifidipine (Nice)
Diltiazem (Drug)

dialates and slows impulse conduction in heart (decreased contractibility)

nervousness, impotence, peripheral edema, flushing, rash, AV block

sustain release tabs (do NOT chew), avoid grapefruit juice, notify MD of low BP, contraindicated in heart block
Term
ARBS
Definition
ends in -sartan

HTN, HF, MI, stroke prevention AND diabetic neuropathy

causes angioedema (monitor and call MD)
renal failure, ortho hypotension
Term
Alpha-blockers
Definition
ends in -osin
blocks receptors in PERIPHERAL blood vessels

HTN, Raynauds, BPH

reflex tachy, nasal congestion, impotence

monitor BUN/Cr, wt, edema; TAKE AT BED
Term
Centrally acting alpha-adrenergics
Definition
Clonodine (Catapres)
Methyldopa (Aldomet)

causes reduction in sympathetic axn in heart by affecting receptors in medulla

decrease CO, rate, and force of contraction

drowsiness, sedation, ortho hypo, CHF

monitor for fluid overload
Term
Direct-acting vasodialators
Definition
Hydralazine (Apresoline)
Minoxidil

relaxes smooth muscle blood vessels; lowers periph resistance

drowsiness, ortho hypotension, sedation, CHF

monitor fluid retention
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