Term
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Definition
•trade name: Lipitor
•therapeutic class: Antihyperlipidemic
•therapeutic use: Reduction of LDL & cholesterol
•pharmacologic class: HMG-CoA reductase inhibitor; statin
•mechanism of action: Reduction of synthesis of cholesterol in liver; increase in LDL receptors in liver |
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Term
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Definition
•trade name: Questran
•therapeutic class: Antihyperlipidemic
•therapeutic use: Reduction of cholesterol
•pharmacologic class: Bile acid resin
•mechanism of action: Prevent enterohepatic recycling of bile acids, increasing elimination of cholesterol |
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Term
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Definition
•trade name: Lopid
•therapeutic class: Antihyperlipidemic
•therapeutic use: To reduce triglycerides & VLDL, and increase HDL
•pharmacologic class: Fibric acid agent
•mechanism of action: Decreases conversion of cholesterol to VLDL, and increase lipoprotein lipase synthesis |
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Term
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Definition
•trade name: Zetia
•therapeutic class: Antihyperlipidemic
•therapeutic use: Adjunct to therapy with statin to reduce LDL
•pharmacologic class: Cholesterol absorption inhibitor
•mechanism of action: Inhibits intestinal absorption of cholesterol |
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Term
| Nicotinic acid (vitamin B) |
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Definition
•trade name: Niaspan
•therapeutic class: Antihyperlipidemic
•therapeutic use: Treatment of hyperlipidemia not responding to diet & weight loss; to slow progression of coronary artery disease (CAD) when combined with a bile acid sequestrant
•pharmacologic class: Other antihyperlipidemics; vitamin
•mechanism of action: Inhibits release of free fatty acids from adipose tissue, increases rate of triglyceride removal from plasma, reduces LDL & triglyceride levels and increases HDL levels |
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