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Details

Antihyperlipidemic Drugs
Part 3
19
Nursing
Graduate
11/02/2014

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Cards

Term
IS EZETIMIBE A PRODRUG?
Definition
YES
Term
WHERE IS EZETIMIBE ABOSRBED AND EXCRETED AT?
Definition
IN THE GI TRACT AND EXCRETED MOSTLY UNCHANGED IN THE FECES
Term
HOW DOES EZETIMIBE WORK?
Definition
BINDS TO CHOLESTEROL TO DECREASE ABSORPTION. INHIBITS THE ABSORPTION OF BILIARY AND DIETARY CHOLESTEROL IN THE SMALL INTESTINE.
Term
A COMBINATION OF EZETIMIBE AND SIMVASTATIN FORM WHAT DRUG?
Definition
VYTORIN
Term
WHAT ARE 2 SIDE EFFECTS OF EZETIMIBE?
Definition
MYALGIAS AND HEADACHES
Term
HOW DOES OMEGA-3 FATTY ACIDS WORK?
Definition
DECREASE TRIGLYCERIDES BY NUCLEAR TRANSCRIPTION REGULATION, SIMILAR TO FIBRATES.
Term
HOW DOES FIBRATES WORK?
Definition
BIND TO AND ACTIVATE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR A (PPARA). CHANGES LIPID METABOLISM TO DECREASE PLASMA TRIGLYCERIDS LEVELS AND INCREASE HDL LEVELS.
Term
WHAT ENZYME DOES FIBRATES INCREASE?
Definition
LIPOPROTEIN LIPASE, WHICH CATALYZES AND HYDROLYZES THE REMOVAL OF TRIGLYCERIDES FROM VLDL.
Term
DOES FIBRATES HAVE AN ANTI-INFLAMMATORY EFFECT?
Definition
YES, IT REDUCES THE RISK OF PLAQUE RUPTURE (LIKE STATINS).
Term
WHERE IS FIBRATES EXCRETED AT?
Definition
URINE AND FECES
Term
WHAT ARE 3 SIDE EFFECTS OF FIBRATES?
Definition
GI UPSET, MYOPATHY, AND IT MAY ELEVATE LFTS
Term
WHAT DRUG INTERACTIONS CAN FIBRATES CAUSE?
Definition
MAY DISPLACE WARFARIN FROM ALBUMIN
Term
WHAT ARE 2 FIBRATES?
Definition
GEMFIBROZIL (LOPID) AND FENOFIBRATE (TRICOR)
Term
WHAT IS NIACIN ALSO KNOWN AS?
Definition
NICOTINIC ACID OR VITAMIN B3
Term
HOW DOES NIACIN WORK?
Definition
LOWERS LDL AND TRIGLYCERIDE LEVLES AND INCREASE HDL LEVELS. INHIBITS THE FORMATION OF HEPATIC VLDL AND LIPOLYSIS.
Term
WHERE IS NIACIN ABOSRBED AT?
Definition
THE GI TRACT
Term
WHAT IS NIACIN METABOLIZED AND EXCRETED AT?
Definition
HEPATIC AND RENAL
Term
WHAT 2 MEDIATIONS WILL DECREASE THE SIDE EFFECTS OF NIACIN?
Definition
ASA OR NSAIDS
Term
WHAT ARE 7 SIDE EFFECTS OF NIACIN?
Definition
FLUSHING, PRUITIS, ELEVATED LFTS OR HEPATITIS, GI UPSET, PUD, DECREASES INSULIN SENSITIVITY, AND POTENTIATE STAIN-INDUCED MYALGIAS.
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