Term
| WHAT IS THE PRECURSOE IN THE LIVER TO DE NOVO (LIKE NEW) CHOLESTEROL SYNTHESIS? |
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Definition
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Term
| WHAT IS THE CATALYST FOR THE FORMATION OF MEVALONIC ACID FROM HMG COA. |
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Definition
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Term
| WHAT IS THE RATE LIMITING STEP IN CHOLESTEROL BIOSYNTHESIS? |
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Definition
| HMG-COA REDUCTASE. IMPORTANT WITH STATINS; NO REDUCTASE= NO MEVALONIC ACID= NO NEW CHOLESTEROL. |
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Term
| ONCE CHOLESTEROL IS DELIVERED TO THE LIVER, HOW IS IT ELMINATED R/T CHOLESTEROL CATABOLISM? |
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Definition
| BY BILIARY SECRETION BY CONVERSION OF CHOLESTEROL TO BILE ACIDS |
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Term
| WHAT HAPPNES TO THE BILE ACIDS WITH CHOLESTEROL CATABOLISM? |
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Definition
| THE MAJORITY OF THE BILE ACIDS ARE RECYCLED BY ENTEROHEPATIC CIRCULATION, WHILE SOME ARE EXCRETED IN THE FECES. |
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Term
| WHAT IS ELEVATED WITH HYPERCHOLESTEROLEMIA? |
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Definition
| ELEVATED TOTAL PLASMA CHOLESTER AND LDL. NML TRIGLYCERIDES. |
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Term
| WHAT IS ELEVATED WITH HYPERTRIGLYCERIDEMIA? |
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Definition
| HIGH PLASMA TRIGLYCERIDES (OVER 200MG/DL). FAMILIAL, BUT RELATED TO AGE, WEIGHT GAIN, OBESITY, DIABETES, AND METABOLIC SYNDROME. |
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Term
| WHAT ARE 3 DISORDERS OF HDL METABOLISM? |
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Definition
| VISCERAL OBESITY, INSULIN RESISTANCE, OR GENETIC |
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Term
| WHAT ARE 10 DISORDERS THAT CAN CAUSE SECONDARY HYPERLIPIDEMIA? |
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Definition
| DM, CRF, HYPOTHYROIDISM, ALCOHOL INGESTION, SEPSIS, STRESS, PREGNANCY, CHOLESTASIS, ANOREXIA NERVOSA, GLUCOCORTICOID AND CORTICOSTEROID TREATMENT. |
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Term
| WHAT ARE HMG-COA REDUCTASE INHIBITORS ALSO KNOWN AS? |
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Definition
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Term
| WHAT TYPE OF DRUGS ARE MOST EFFECTIVE FOR REDUCING PLASMA CHOLESTEROL LEVELS, ESPECIALLY LDL? |
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Definition
| HMG-COA REDUCTASE INHIBITORS. THESE ARE NOT EFFECTIVE IN TREATMENT OF HYPERTRIGLYCERIDEMIA. |
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Term
| WHAT GROUP OF DRUGS DECREASE THE OXIDATIVE STRESS AND INFLAMMATION BY STABILIZING ATHEROSCLEROSIS. |
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Definition
| STATINS; WHICH ARE CARDIOPROTECTIVE AND USEFUL IN PREVENTION OF CORONARY ARTERY DISEASE. |
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Term
| DECREASED FORMATION OF VLDL/LDL CAUSES UPREGULATION OF WHAT? |
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Definition
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Term
| DOES STATINS HAVE AN EXTENSIVE FIRST-PASS HEPATIC EFFECT? |
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Definition
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Term
| WHAT TYPE OF HALF-LIVES DOWN STAINS HAVE? |
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Definition
| SHORT. BUT MAY STILL BE TAKEN ONCE DAILY (TAKEN @ NIGHT B/C THAT'S WHEN MOST CHOLESTEROL IS MADE). |
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Term
| WHAT IS UNIQUE ABOUT OVASARTAN AND SIMVASTATIN? |
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Definition
| THEY ARE BOTH PRODRUGS, AND THEY BOTH CROSS THE BBB AND CAN CAUSE SLEEP DISTURBANCES IN SOME PATIENTS. |
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Term
| WHAT IS A RARE SIDE EFFECT OF STATINS? |
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Definition
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Term
| WHAT ARE SOME GI UPSETS R/T STATINS? 4 ANSWERS |
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Definition
| ABDOMINAL CRAMPS, CONSTIPATION, DIARRHEA, REFLUX |
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Term
| WHAT IS A SIDE EFFECT OF MUSCLES R/T STATINS? |
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Definition
| MYALGIAS (MUSCLE CELL WALLS NEED CHOLESTEROL TO FORM) MAY BE INCREASED POSTOPERATIVELY IF SUX IS USED. |
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Term
| WHAT ARE FOR CONTRAINDICATIONS FOR STATIN USE? |
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Definition
| HEPATIC DISEASE, PREGNANCY, LACTATION, OR FOR WOEMEN WHO HAVE AN INTENT TO BECOME PREGNANT (TERATOGENIC) |
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Term
| HOW DOES BILE ACID-BINDING RESINS WORK? |
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Definition
| BIND TO BILE ACIDS IN THE SMALL INTESTINE TO INCREASE THE AMOUNT OF EXCRETION. WITH LESS BILE ACIDS PRESENT, THE LIVER "LOOKS" FOR MORE CHOLESTEROL. |
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Term
| WHAT DOES BILE ACID-BINDING RESINS DO RO RECEPTORS? |
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Definition
| UPREGULATION OF RECEPTORS DECREASES PLASMA LEVLES OF LDL AND INCREASES HEPATIC UPTAKE. |
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Term
| ARE BILE ACID-BINDING RESINS ABSORBED SYSTEMICALLY? |
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Definition
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Term
| WHAT DOES BILE ACID-BINDING RESINS DECREASE THE ABSORPTION OF? |
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Definition
| VITAMINS (INCLUDING VITAMIN K WHICH CAUSES BLEEDING) |
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Term
| WHAT ARE 3 SIDE EFFECTS OF BILE ACID-BINDING RESINS? |
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Definition
| BLOATING, CRAMPING, AND REFLUX |
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Term
| WHAT ARE 3 BILE ACID-BINDING RESINS? |
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Definition
| CHOLESTYRAMINE (QUESTRAN), COLESEVELAM (WELCHOL), AND COLESTIPOL (COLESTID) |
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